A transcriptional response to replication stress selectively expands a subset of BRCA2-mutant mammary epithelial cells
This is the repository of scripts and data used for the paper "A transcriptional response to replication stress selectively expands a subset of BRCA2-mutant mammary epithelial cells"
Custom code was not generated for this manuscript. The following publicly available pipelines were utilized for analysis: raw sequencing data were processed using the 10X Genomics Cell Ranger pipeline (https://github.com/10XGenomics/cellranger), standard preprocessing and quality control of scRNA-seq data was based on Seurat Guided tutorials (http://satijalab.org/seurat/).
R Version: 4.1.3 Cell Ranger version: 6.0.2 Seurat version: 4.0
Requires only a standard computer with enough RAM to support the in-memory operations
The image generation R-scripts depend on the following packages.
Seurat
dplyr
cowplot
ggplot2
This project is covered under the GNU V3 License.