A data-only living systematic review
Clinical summary: This meta-analysis suggests that vitamin D supplementation is associated with a reduction in fractures when given in effective doses (see Figure). Effective is defined as a dose that raises the serum level of vitamin D by 20 nmol/L (8 ng/mL) and achieves a final level of at least 60 nmol/L (24 ng/mL). Heterogeneity of results as measured by I2 in this subgroup 'might not be important' at 30%. This review updates a previously published meta-analysis.
- Reconciliation of conclusions with prior meta-analyses (under construction)
- Keep current with this topic (not available)
Methods overview: This repository is an openMetaAnalysis that combines methods of scoping, rapid, and living systematic reviews. This analysis updates one or more previously published review(s).(1) A comparison of studies include in this review compared to prior reviews are in the table, reconciliation of trials included with prior meta-analyses/. Newer studies included are listed in the references below. Rationale for newer trials excluded may be listed at the end of the references.
- Methods for openMetaAnalysis
- Evidence search for this review
See methods for details.
Results: Details of the studies included are in the:
- Reconciliation of trials included with prior meta-analyses/ (under construction)
- Description of studies (PICO table) (under construction)
- Risk of bias assessment (under construction)
- Forest plots (source data)
- Network plots (optional)
The forest plot for the primary outcomes are below. Additional forest plots of secondary analyses may be available.
The meta-regression for the primary outcomes are below. Additional meta-regressions of secondary analyses may be available.
- Zhao JG, Zeng XT, Wang J, Liu L. Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. JAMA. 2017 Dec 26;318(24):2466-2482. doi: 0.1001/jama.2017.19344. PMID: 29279934
- Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014 Jan 11;383(9912):146-55. doi: 10.1016/S0140-6736(13)61647-5. PMID: 24119980.
- Avenell A, Mak JC, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014 Apr 14;(4):CD000227. doi: 10.1002/14651858.CD000227.pub4. PMID: 24729336
- Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012 Jul 5;367(1):40-9. doi: 10.1056/NEJMoa1109617. PMID: 22762317.
- Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2011 Dec 20;155(12):827-38. doi: 10.7326/0003-4819-155-12-201112200-00005. PMID: 22184690.
- Neelemaat F, Lips P, Bosmans JE, Thijs A, Seidell JC, van Bokhorst-de van der Schueren MA. Short-term oral nutritional intervention with protein and vitamin D decreases falls in malnourished older adults. J Am Geriatr Soc. 2012 Apr;60(4):691-9. doi: 10.1111/j.1532-5415.2011.03888.x. PMID: 22316322.
- Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 Dec 2;2(12):e1917789. doi: 10.1001/jamanetworkopen.2019.17789. PMID: 31860103; PMCID: PMC6991219.
This repository is cited by:
- WikiDoc contributors. Pending content page. WikiDoc. Nov 9, 2014. Available at: http://www.wikidoc.org/index.php/This_topic. Accessed November 9, 2014.
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