New molecular entities

[MaaikevS]

Here is a list of molecular entities that would be good to add. Naming convention (abbreviation vs full name) needs to be decided on.

I would like to propose to do this in stages and prioritise the more pressing ones first. Please feel free to indicate which ones need prioritisation.

name	synonym	interlex	preferredOntology	KnowledgeSpace
4-DAMP methobromide		http://uri.interlex.org/base/ilx_0686819	http://id.nlm.nih.gov/mesh/2018/M0125168, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0096896
acetylcholine	Ach	http://uri.interlex.org/ilx_0100240	http://uri.neuinfo.org/nif/nifstd/sao185580330
AgRP	agouti-related protein agouti-related peptide AGRP ART AGRT		http://purl.obolibrary.org/obo/PR_000003846	https://knowledge-space.org/wiki/PR:000003846#agouti-related-protein
APV	(2R)-amino-5-phosphonovaleric acid AP5	http://uri.neuinfo.org/nif/nifstd/nlx_94485
Cav2.1 channel	P/Q voltage-dependent calcium channel
CGP 54626		http://uri.interlex.org/ilx_0439399	http://id.nlm.nih.gov/mesh/2018/M0279326
cholecystokinin	CCK	http://uri.interlex.org/ilx_0102124	http://uri.neuinfo.org/nif/nifstd/nifext_5068
Choline Acetyltransferase	ChAT Choline acetylase	http://uri.interlex.org/base/ilx_0102129	http://uri.neuinfo.org/nif/nifstd/sao722953401
CNQX	cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione)	http://uri.neuinfo.org/nif/nifstd/nlx_14886
DAPi	4,6-diamidino-2-phenylindole
delta opioid receptor	delta DOR	http://uri.neuinfo.org/nif/nifstd/nifext_6921
DNQX	6,7-dinitroquinoxaline-2,3-dione	http://uri.neuinfo.org/nif/nifstd/nlx_76042
dopamine	DA dopamin deoxyepinephrine dopamine HCl hydroxyltyramine	http://uri.interlex.org/base/ilx_0103384	http://purl.obolibrary.org/obo/CHEBI_18243	https://knowledge-space.org/wiki/CHEBI:18243#dopamine
dopamine transporter	DAT dopamine active transporter	http://uri.interlex.org/base/ilx_0103388	http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090512, http://purl.obolibrary.org/obo/PR_000015188	https://knowledge-space.org/wiki/NLXMOL:20090512#dopamine-transporter
dopaminergic antagonist			https://www.ebi.ac.uk/chebi/searchId.do?chebiId=48561
DPCPX	cyclopentyl-1,3-dipropylxanthine		http://id.nlm.nih.gov/mesh/2018/M0255708
Dyn	Dynorphin	http://uri.interlex.org/ilx_0103624	http://uri.neuinfo.org/nif/nifstd/nifext_5097
Enk	Enkephalin	http://uri.interlex.org/base/ilx_0103826	http://uri.neuinfo.org/nif/nifstd/nifext_5096
epibatidine		http://uri.interlex.org/ilx_0103884	http://uri.neuinfo.org/nif/nifstd/nlx_chem_20090204
epinephrine	adrenaline AD EPI	http://uri.interlex.org/ilx_0103891	https://www.drugbank.ca/drugs/DB00668
flumazenil		http://uri.interlex.org/base/ilx_0104307	http://purl.obolibrary.org/obo/CHEBI_5103
Forkhead box protein P2	FoxP2
gabazine	SR-95531	http://uri.interlex.org/base/ilx_0572043	http://id.nlm.nih.gov/mesh/2018/M0142643, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0628385
galanin	GAL	http://uri.interlex.org/base/ilx_0104529	http://uri.neuinfo.org/nif/nifstd/nifext_5074	https://knowledge-space.org/wiki/NIFEXT:5074#galanin
ghrelin	GHRL		http://uri.neuinfo.org/nif/nifstd/nifext_5076	https://knowledge-space.org/wiki/NIFEXT:5076#ghrelin
GIRK channel	G Protein-Coupled Inwardly-Rectifying Potassium Channel	http://id.nlm.nih.gov/mesh/2018/M0451133
GIRK2 channel	G protein-activated inward rectifier potassium channel 2		http://purl.obolibrary.org/obo/PR_000002003	https://knowledge-space.org/wiki/PR:000002003#g-protein-activated-inward-rectifier-potassium-channel-2
GLP1	glucagon-like peptide 1		http://uri.neuinfo.org/nif/nifstd/nifext_5143	https://knowledge-space.org/wiki/NIFEXT:5143#glucagon-like-peptide-1
GluA1 receptor	AMPA receptor subunit A1, GluA1 AMPA receptor
GluA2 receptor	AMPA receptor subunit A2, GluA2 AMPA receptor
GluA3 receptor	AMPA receptor subunit A3, GluA3 AMPA receptor
glutamate	Glu Glut	http://uri.interlex.org/base/ilx_0104676	http://uri.neuinfo.org/nif/nifstd/sao1744435799	https://knowledge-space.org/wiki/SAO:1744435799#glutamate
glutamate transporter 1	GLT1
histamine		http://uri.interlex.org/base/ilx_0105065	http://uri.neuinfo.org/nif/nifstd/nifext_5016	https://knowledge-space.org/wiki/NIFEXT:5016#histamine
insulin	INS		http://purl.obolibrary.org/obo/PR_000009054	https://knowledge-space.org/wiki/PR:000009054#insulin
kappa opioid receptor	kappa KOR	http://uri.neuinfo.org/nif/nifstd/nifext_5660
Kv4 channel		http://uri.neuinfo.org/nif/nifstd/nifext_2719
leptin	LEP OB obese protein obesity factor OBS		http://purl.obolibrary.org/obo/PR_000009758	https://knowledge-space.org/wiki/PR:000009758#leptin-1
Lucifer Yellow	LY	http://uri.interlex.org/base/ilx_0439021	http://id.nlm.nih.gov/mesh/2018/M0068243, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0065228
metabotropic glutamate receptor	mGluR mGluRs GRM Glutamate metabotropic	http://uri.interlex.org/base/ilx_0106829	http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090503
mGlu1A receptor
mGluR1	metabotropic glutamate receptor 1 GRM1 Glutamate metabotropic receptor 1 metabotropic glutamate 1	http://uri.interlex.org/ilx_0106891	http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090504
mGluR2	metabotropic glutamate receptor 2 GRM2 Glutamate metabotripic receptor 2 Glutamate metabotropic 2	http://uri.interlex.org/ilx_0106892	http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090505
mGluR5	metabotropic glutamate receptor 5 GRM5 Glutamate metabotropic receptor 5 mGlu5 glutamate metabotropic 5	http://uri.interlex.org/ilx_0106895	http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090508
MK-801		http://uri.interlex.org/base/ilx_0496139	http://id.nlm.nih.gov/mesh/2018/M0350546, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0813872
mu opioid receptor	µ opioid receptor mu receptor MOR µ-OR µ mu	http://uri.neuinfo.org/nif/nifstd/nifext_6921
muscarinic receptor subunit 4	M4 M4 receptor M4R
muscimol		http://id.nlm.nih.gov/mesh/2018/M0014231	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A7035
nicotinic alpha4 beta2 receptor
norepinephrine	noradrenaline, NE, Nad, NA	http://uri.interlex.org/ilx_0107680	http://uri.neuinfo.org/nif/nifstd/nifext_5013	https://knowledge-space.org/wiki/NIFEXT:5013#norepinephrine
NPY	neuropeptide Y		http://uri.neuinfo.org/nif/nifstd/nifext_5090, http://purl.obolibrary.org/obo/PR_000011387	https://knowledge-space.org/wiki/NIFEXT:5090#neuropeptide-y, https://knowledge-space.org/wiki/PR:000011387#neuropeptide-y-1
NPY receptor			http://uri.neuinfo.org/nif/nifstd/nifext_5809	https://knowledge-space.org/wiki/NIFEXT:5809#neuropeptide-y-receptor
NTS	neurotensin	http://uri.interlex.org/base/ilx_0107542	http://uri.neuinfo.org/nif/nifstd/nifext_5092	https://knowledge-space.org/wiki/NIFEXT:5092#neurotensin
oxotremorine-M		http://uri.interlex.org/base/ilx_0522069	http://id.nlm.nih.gov/mesh/2018/M0126067, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0069796
oxytocin	Oxt OXT OT	http://uri.interlex.org/base/ilx_0108336	http://purl.obolibrary.org/obo/CHEBI_7872	https://knowledge-space.org/wiki/CHEBI:7872#oxytocin
panAMPA receptor	GluA1-3 receptor
phthalimide-azo-iperoxo	PAI	photo-switchable muscarinic agonist
picrotoxin	PTX	http://uri.interlex.org/ilx_0108877
pirenzepine		http://uri.interlex.org/base/ilx_0108914	http://purl.obolibrary.org/obo/CHEBI_8247
prazosin		http://uri.interlex.org/base/ilx_0109181	http://purl.obolibrary.org/obo/CHEBI_8364
SCH23390
serotonin	5-hydroxytryptamine 5-HT	http://uri.interlex.org/base/ilx_0110557	http://uri.neuinfo.org/nif/nifstd/sao711465902
SK channel	small conductance calcium-activated potassium channel
SK2 channel	small conductance calcium-activated potassium channel protein 2 SKCa2, KCNN2		http://purl.obolibrary.org/obo/PR_000000713
substance P	SP	http://uri.interlex.org/base/ilx_0111205	http://uri.neuinfo.org/nif/nifstd/nifext_5117	https://knowledge-space.org/wiki/NIFEXT:5117#substance-p
tetrodotoxin	TTX	http://id.nlm.nih.gov/mesh/2018/M0021255
UK-14,304		http://uri.interlex.org/base/ilx_0502583	http://id.nlm.nih.gov/mesh/2018/M0065042, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0147760
vasopressin	antidiuretic hormone ADH	http://uri.interlex.org/ilx_0112270	https://www.drugbank.ca/drugs/DB00067
vesicular GABA transporter	vGAT VGAT
ZM 241385		http://uri.interlex.org/base/ilx_0539235	http://id.nlm.nih.gov/mesh/2018/M0255708, https://ncimeta.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C0384965

[lzehl]

should we prioritize after available information?

1. all terms with InterLex + preferred onotology
2. all terms with InterLex only
3. all terms with preferred ontology only
4. all terms with no external reference

[MaaikevS]

@lzehl That sounds like a sensible prioritisation.
I can make a start for some of them if you like

[lzehl]

@MaaikevS yes please :)