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statistical method for testing degree of clustering/distance between groups of TCRs? #45

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dxl3742 opened this issue Apr 8, 2024 · 0 comments
Open

statistical method for testing degree of clustering/distance between groups of TCRs? #45

dxl3742 opened this issue Apr 8, 2024 · 0 comments

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@dxl3742
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dxl3742 commented Apr 8, 2024

Hi there,
Great work on the package!
I've been using tcrdist3 to compute pairwise distance between my tcr sequences. I want to say that one group of tcr sequences are more clustered (more close together, more similar) than another group. How best could I go about testing this? Should I go from the network and calculate say number of nodes for each group, or from the distance matrix and use PERMANOVA or something similar?
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