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parameters.md

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Parameters

  • CMAX: maximum concentration, Cmax
  • CMAXD: CMAX / Dose, Cmax / Dose
  • TMAX: time of maximum concentration, Tmax
  • TLAG: time until first nonzero concentration, for extravascular administration only
  • CLST: last positive concentration observed, Clast
  • CLSTP: last positive concentration predicted, Clast_pred
  • TLST: time of last positive concentration, Tlast
  • LAMZHL: half-life by lambda z, ln(2)/LAMZ
  • LAMZ: lambda_z negative of best fit terminal slope
  • LAMZLL: earlist time for LAMZ
  • LAMZUL: last time for LAMZ
  • LAMZNPT: number of points for LAMZ
  • CORRXY: correlaton of log(concentration) and time
  • R2: R-squared
  • R2ADJ: R-squared adjusted
  • C0: back extrapolated concentration at time 0, for bolus intravascular administration only
  • AUCLST: AUC from 0 to TLST
  • AUCALL: AUC using all the given points, including trailing zero concentrations
  • AUCIFO: AUC infinity observed
  • AUCIFOD: AUCIFO / Dose
  • AUCIFP: AUC infinity predicted using CLSTP instead of CLST
  • AUCIFPD: AUCIFP / Dose
  • AUCPEO: AUC % extrapolation observed
  • AUCPEP: AUC % extrapolated for AUCIFP
  • AUCPBEO: AUC % back extrapolation observed, for bolus IV administration only
  • AUCPBEP: AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
  • AUMCLST: AUMC to the TLST
  • AUMCIFO: AUMC infinity observed using CLST
  • AUMCIFP: AUMC infinity determiend by CLSTP
  • AUMCPEO: AUMC % extrapolated observed
  • AUMCPEP: AUMC % extrapolated predicted
  • MRTIVLST: mean residence time(MRT) to TLST, for intravascular administration
  • MRTIVIFO: mean residence time(MRT) infinity using CLST, for intravascular administration
  • MRTIVIFP: mean residence time(MRT) infinity ucinsg CLSTP, for intravascular administration
  • MRTEVLST: mean residence time(MRT) to TLST, for extravascular administration
  • MRTEVIFO: mean residence time(MRT) infinity using CLST, for extravascular administration
  • MRTEVIFP: mean residence time(MRT) infinity ucinsg CLSTP, for extravascular administration
  • VZO: volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
  • VZP: volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
  • VZFO: VZO for extravascular administration, VZO/F, F is bioavailability
  • VZFP: VZP for extravascular administration, VZP/F, F is bioavailability
  • CLO: clearance using AUCIFO, for intravascular administration
  • CLP: clearance using AUCIFP, for intravascular administration
  • CLFO: CLO for extravascular administration, CLO/F, F is bioavailability
  • CLFP: CLP for extravascular administration, CLP/F, F is bioavailability
  • VSSO: volume of distribution at steady state using CLST, for intravascular administration only
  • VSSP: volume of distribution at stead state using CLSTP, for intravascular administration only