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f_design_fisher_combination_test.R
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f_design_fisher_combination_test.R
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## |
## | *Fisher combination test*
## |
## | This file is part of the R package rpact:
## | Confirmatory Adaptive Clinical Trial Design and Analysis
## |
## | Author: Gernot Wassmer, PhD, and Friedrich Pahlke, PhD
## | Licensed under "GNU Lesser General Public License" version 3
## | License text can be found here: https://www.r-project.org/Licenses/LGPL-3
## |
## | RPACT company website: https://www.rpact.com
## | rpact package website: https://www.rpact.org
## |
## | Contact us for information about our services: info@rpact.com
## |
## | File version: $Revision: 7742 $
## | Last changed: $Date: 2024-03-22 13:46:29 +0100 (Fr, 22 Mrz 2024) $
## | Last changed by: $Author: pahlke $
## |
#' @include f_core_constants.R
#' @include f_core_utilities.R
#' @include f_logger.R
NULL
.getFisherCombinationSize <- function(kMax, alpha0Vec, criticalValues, tVec,
cases = .getFisherCombinationCases(kMax = kMax, tVec = tVec)) {
return(.getFisherCombinationSizeCpp(kMax, alpha0Vec, criticalValues, tVec, cases))
}
#' @title
#' Get Design Fisher
#'
#' @description
#' Performs Fisher's combination test and returns critical values for this design.
#'
#' @inheritParams param_kMax
#' @inheritParams param_alpha
#' @param method \code{"equalAlpha"}, \code{"fullAlpha"}, \code{"noInteraction"}, or \code{"userDefinedAlpha"},
#' default is \code{"equalAlpha"} (for details, see Wassmer, 1999).
#' @inheritParams param_userAlphaSpending
#' @param alpha0Vec Stopping for futility bounds for stage-wise p-values.
#' @inheritParams param_informationRates
#' @inheritParams param_sided
#' @param bindingFutility If \code{bindingFutility = TRUE} is specified the calculation of
#' the critical values is affected by the futility bounds (default is \code{TRUE}).
#' @param tolerance The numerical tolerance, default is \code{1e-14}.
#' @param iterations The number of simulation iterations, e.g.,
#' \code{getDesignFisher(iterations = 100000)} checks the validity of the critical values for the design.
#' The default value of \code{iterations} is 0, i.e., no simulation will be executed.
#' @param seed Seed for simulating the power for Fisher's combination test. See above, default is a random seed.
#' @inheritParams param_three_dots
#'
#' @details
#' \code{getDesignFisher()} calculates the critical values and stage levels for
#' Fisher's combination test as described in Bauer (1989), Bauer and Koehne (1994),
#' Bauer and Roehmel (1995), and Wassmer (1999) for equally and unequally sized stages.
#'
#' @seealso \code{\link[=getDesignSet]{getDesignSet()}} for creating a set of designs to compare.
#'
#' @template return_object_trial_design
#' @template how_to_get_help_for_generics
#'
#' @family design functions
#'
#' @template examples_get_design_fisher
#'
#' @export
#'
getDesignFisher <- function(...,
kMax = NA_integer_,
alpha = NA_real_,
method = c("equalAlpha", "fullAlpha", "noInteraction", "userDefinedAlpha"), # C_FISHER_METHOD_DEFAULT
userAlphaSpending = NA_real_,
alpha0Vec = NA_real_,
informationRates = NA_real_,
sided = 1, # C_SIDED_DEFAULT
bindingFutility = NA,
tolerance = 1e-14, # C_ANALYSIS_TOLERANCE_FISHER_DEFAULT
iterations = 0,
seed = NA_real_) {
.assertIsValidTolerance(tolerance)
.assertIsValidIterationsAndSeed(iterations, seed)
.warnInCaseOfUnknownArguments(functionName = "getDesignFisher", ...)
return(.getDesignFisher(
kMax = kMax, alpha = alpha, method = method,
userAlphaSpending = userAlphaSpending, alpha0Vec = alpha0Vec, informationRates = informationRates,
sided = sided, bindingFutility = bindingFutility,
tolerance = tolerance, iterations = iterations, seed = seed, userFunctionCallEnabled = TRUE
))
}
.getDesignFisherDefaultValues <- function() {
return(list(
kMax = NA_integer_,
alpha = NA_real_,
method = C_FISHER_METHOD_DEFAULT,
userAlphaSpending = NA_real_,
alpha0Vec = NA_real_,
informationRates = NA_real_,
sided = 1,
bindingFutility = C_BINDING_FUTILITY_FISHER_DEFAULT,
tolerance = C_ANALYSIS_TOLERANCE_FISHER_DEFAULT,
iterations = 0,
seed = NA_real_
))
}
#'
#' @param userFunctionCallEnabled if \code{TRUE}, additional parameter validation methods will be called.
#'
#' @noRd
#'
.getDesignFisher <- function(kMax = NA_integer_, alpha = NA_real_, method = C_FISHER_METHOD_DEFAULT,
userAlphaSpending = NA_real_, alpha0Vec = NA_real_, informationRates = NA_real_,
sided = 1, bindingFutility = C_BINDING_FUTILITY_FISHER_DEFAULT,
tolerance = C_ANALYSIS_TOLERANCE_FISHER_DEFAULT, iterations = 0, seed = NA_real_,
userFunctionCallEnabled = FALSE) {
method <- .matchArgument(method, C_FISHER_METHOD_DEFAULT)
.assertIsNumericVector(alpha0Vec, "alpha0Vec", naAllowed = TRUE)
if (.isDefinedArgument(kMax, argumentExistsValidationEnabled = userFunctionCallEnabled)) {
.assertIsValidKMax(kMax, kMaxUpperBound = C_KMAX_UPPER_BOUND_FISHER)
if (!is.integer(kMax)) {
kMax <- as.integer(kMax)
}
}
if (!is.integer(sided) && sided %in% c(1, 2)) {
sided <- as.integer(sided)
}
if (sided != 1) {
stop(C_EXCEPTION_TYPE_ILLEGAL_ARGUMENT, "Fisher's combination test only available for one-sided testing")
}
if (is.na(bindingFutility)) {
bindingFutility <- C_BINDING_FUTILITY_FISHER_DEFAULT
} else if (userFunctionCallEnabled &&
((!is.na(kMax) && kMax == 1) ||
(!any(is.na(alpha0Vec)) && all(alpha0Vec == C_ALPHA_0_VEC_DEFAULT)))) {
warning("'bindingFutility' (", bindingFutility, ") will be ignored", call. = FALSE)
}
design <- TrialDesignFisher$new(
kMax = kMax,
alpha = alpha,
method = method,
sided = sided,
userAlphaSpending = userAlphaSpending,
alpha0Vec = alpha0Vec,
informationRates = informationRates,
bindingFutility = bindingFutility,
tolerance = tolerance,
iterations = as.integer(iterations),
seed = seed
)
.assertDesignParameterExists(design, "sided", C_SIDED_DEFAULT)
.assertIsValidSidedParameter(design$sided)
.assertDesignParameterExists(design, "method", C_FISHER_METHOD_DEFAULT)
.assertIsSingleCharacter(design$method, "method")
if (!.isFisherMethod(design$method)) {
stop(
C_EXCEPTION_TYPE_ILLEGAL_ARGUMENT,
"'method' must be one of the following: ", .printFisherMethods()
)
}
.assertDesignParameterExists(design, "bindingFutility", C_BINDING_FUTILITY_FISHER_DEFAULT)
.assertDesignParameterExists(design, "tolerance", C_ANALYSIS_TOLERANCE_FISHER_DEFAULT)
.setKmaxBasedOnAlphaSpendingDefintion(design)
design$informationRates <- .getValidatedInformationRates(design)
design$alpha0Vec <- .getValidatedAlpha0Vec(design)
if (design$sided == 2 && design$bindingFutility && any(design$alpha0Vec < 1)) {
warning("Binding futility will be ignored because the test is defined as two-sided", call. = FALSE)
}
if (design$method == C_FISHER_METHOD_USER_DEFINED_ALPHA) {
.validateUserAlphaSpending(design)
} else {
design$.setParameterType("userAlphaSpending", C_PARAM_NOT_APPLICABLE)
if (.isDefinedArgument(design$userAlphaSpending)) {
warning("'userAlphaSpending' will be ignored because 'method' is not '",
C_FISHER_METHOD_USER_DEFINED_ALPHA, "'",
call. = FALSE
)
}
}
if (.isUndefinedArgument(design$alpha)) {
design$alpha <- C_ALPHA_DEFAULT
}
.assertDesignParameterExists(design, "alpha", C_ALPHA_DEFAULT)
.assertIsSingleNumber(design$alpha, "alpha")
.assertIsValidSidedParameter(sided)
if (sided != 1) {
design$alpha <- design$alpha / sided
}
if (userFunctionCallEnabled) {
.assertIsValidAlpha(design$alpha)
}
.assertDesignParameterExists(design, "kMax", 3)
.assertIsSingleInteger(design$kMax, "kMax")
.assertIsValidKMax(design$kMax, kMaxUpperBound = C_KMAX_UPPER_BOUND_FISHER)
if (design$method == C_FISHER_METHOD_NO_INTERACTION && design$kMax < 3) {
stop(
C_EXCEPTION_TYPE_ILLEGAL_ARGUMENT,
"method '", C_FISHER_METHOD_NO_INTERACTION,
"' is only allowed for kMax > 2 (kMax is ", design$kMax, ")"
)
}
if (design$kMax > 1) {
design$scale <- round(sqrt((design$informationRates[2:design$kMax] -
design$informationRates[1:(design$kMax - 1)]) / design$informationRates[1]), 10)
}
design$criticalValues <- rep(NA_real_, design$kMax)
design$.setParameterType("scale", C_PARAM_NOT_APPLICABLE)
design$.setParameterType("criticalValues", C_PARAM_GENERATED)
if (design$bindingFutility) {
alpha0Vec <- design$alpha0Vec
} else {
alpha0Vec <- rep(1, design$kMax - 1)
}
if (design$method == C_FISHER_METHOD_NO_INTERACTION && !any(is.na(alpha0Vec)) &&
all(alpha0Vec == C_ALPHA_0_VEC_DEFAULT)) {
stop(
C_EXCEPTION_TYPE_ILLEGAL_ARGUMENT,
"for specified 'method' (\"", C_FISHER_METHOD_NO_INTERACTION,
"\") the 'alpha0Vec' must be unequal to ", .arrayToString(alpha0Vec, vectorLookAndFeelEnabled = TRUE),
" and 'bindingFutility' must be TRUE"
)
}
design$.setParameterType("stageLevels", C_PARAM_GENERATED)
design$.setParameterType("alphaSpent", C_PARAM_GENERATED)
design$.setParameterType("nonStochasticCurtailment", C_PARAM_GENERATED)
tryCatch(
{
cases <- .getFisherCombinationCases(kMax = design$kMax, tVec = design$scale)
result <- .getDesignFisherInner(
design$kMax, design$alpha, design$tolerance,
design$criticalValues, design$scale, alpha0Vec,
design$userAlphaSpending, design$method
)
design$criticalValues <- result$criticalValues
design$alphaSpent <- result$alphaSpent
design$stageLevels <- result$stageLevels
design$nonStochasticCurtailment <- result$nonStochasticCurtailment
size <- result$size
design$stageLevels <- sapply(1:design$kMax, function(k) {
.getFisherCombinationSize(k, rep(1, k - 1),
rep(design$criticalValues[k], k), design$scale,
cases = cases
)
})
design$alphaSpent <- sapply(1:design$kMax, function(k) {
.getFisherCombinationSize(k, alpha0Vec[1:(k - 1)],
design$criticalValues[1:k], design$scale,
cases = cases
)
})
design$nonStochasticCurtailment <- FALSE
if (design$stageLevels[1] < 1e-10) {
design$criticalValues[1:(design$kMax - 1)] <- design$criticalValues[design$kMax]
design$stageLevels <- sapply(
1:design$kMax,
function(k) {
.getFisherCombinationSize(k, rep(1, k - 1),
rep(design$criticalValues[k], k), design$scale,
cases = cases
)
}
)
design$alphaSpent <- sapply(
1:design$kMax,
function(k) {
.getFisherCombinationSize(k, alpha0Vec[1:(k - 1)],
design$criticalValues[1:k], design$scale,
cases = cases
)
}
)
design$nonStochasticCurtailment <- TRUE
}
},
error = function(e) {
warning("Output may be wrong because an error occured: ", e$message, call. = FALSE)
}
)
if (userFunctionCallEnabled) {
if (design$method == C_FISHER_METHOD_NO_INTERACTION && abs(size - design$alpha) > 1e-03) {
stop(C_EXCEPTION_TYPE_RUNTIME_ISSUE, "numerical overflow in computation routine")
}
if (design$method == C_FISHER_METHOD_EQUAL_ALPHA && !all(is.na(design$stageLevels)) &&
abs(mean(na.omit(design$stageLevels)) - design$stageLevels[1]) > 1e-03) {
stop(C_EXCEPTION_TYPE_RUNTIME_ISSUE, "numerical overflow in computation routine")
}
if (design$kMax > 1) {
diff <- na.omit(design$criticalValues[2:design$kMax] - design$criticalValues[1:(design$kMax - 1)])
if (length(diff) > 0 && any(diff > 1e-12)) {
.logDebug(
"Stop creation of Fisher design because critical values are ",
.arrayToString(design$criticalValues, vectorLookAndFeelEnabled = TRUE), ", ",
"i.e., differences are ", .arrayToString(diff, vectorLookAndFeelEnabled = TRUE)
)
stop(C_EXCEPTION_TYPE_RUNTIME_ISSUE, "no calculation possible")
}
if (!all(is.na(design$stageLevels)) && any(na.omit(design$stageLevels[1:(design$kMax - 1)]) > design$alpha)) {
stop(
C_EXCEPTION_TYPE_ILLEGAL_ARGUMENT,
"'alpha' (", design$alpha, ") not correctly specified"
)
}
}
if (design$method == C_FISHER_METHOD_USER_DEFINED_ALPHA) {
if (any(abs(design$alphaSpent - design$userAlphaSpending) > 1e-05)) {
stop(
C_EXCEPTION_TYPE_ILLEGAL_ARGUMENT,
"'alpha' (", design$alpha, ") or 'userAlphaSpending' (",
.arrayToString(design$userAlphaSpending), ") not correctly specified"
)
}
}
}
design$.setParameterType("simAlpha", C_PARAM_NOT_APPLICABLE)
design$simAlpha <- NA_real_
if (!is.null(design$iterations) && !is.na(design$iterations) && design$iterations > 0) {
design$.setParameterType("seed", ifelse(!is.null(design$seed) && !is.na(design$seed),
C_PARAM_USER_DEFINED, C_PARAM_DEFAULT_VALUE
))
design$seed <- .setSeed(design$seed)
design$simAlpha <- .getSimulatedAlphaCpp(
kMax = design$kMax,
alpha0 = design$alpha0Vec,
criticalValues = design$criticalValues,
tVec = design$scale,
iterations = iterations
)
design$.setParameterType("simAlpha", C_PARAM_GENERATED)
design$.setParameterType("iterations", C_PARAM_USER_DEFINED)
}
if (design$kMax == 1) {
design$.setParameterType("alpha0Vec", C_PARAM_NOT_APPLICABLE)
}
if (length(design$alpha0Vec) == 0 ||
all(design$alpha0Vec == C_ALPHA_0_VEC_DEFAULT)) {
design$.setParameterType("bindingFutility", C_PARAM_NOT_APPLICABLE)
}
design$.initStages()
return(design)
}