Query: AUPR

[nfancy]

Hi,

Thanks for this nice package. Really helpful for cell-cell communication detection. Do you recommend a range of AUPR_corrected value that can determine moderate to strong ligand activity. In other words, what value can be considered as a notable ligand activity?

Thanks.
Nurun

[Eisuan]

Thank you for your interest in NicheNet. We have not defined a specific cutoff of AUPR/AUPR corrected because these values can show high variability among different datasets.

I would stress the fact that it is advisable to focus on the biological interpretation of the results rather than the quantitative meaning of the absolute AUPR scores. In practice, we would advise inspecting if the top AUPR/AUPR corrected prioritized ligands make sense given the biological context of interest (e.g. prioritization of previously described ligand-receptor interactions).

Bests,
Daniele