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Can you paste your error here? How much RAM does your machine have? I think the minimum possible RAM you'll need would be about 60 GB but probably more depending on data types and fragmentation.
The memory should be recovered the soon as the program exits. If you need to clear additional memory, you should use the task manager for your operating system to kill additional programs.
Memory issue when i working with connected-components-3d ? volume images shape are 1000 X 1500 X 7000 ?
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