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DESCRIPTION
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Package: mtbls297
Version: 0.99.1
Date: 2019-05-07
Encoding: UTF-8
Title: MetaboLights MTBLS297: Multiomics of tomato glandular trichomes
reveals distinct features of central carbon metabolism
supporting high productivity of specialized metabolites. Balcke et al. (2017)
Author: Steffen Neumann <sneumann@ipb-halle.de>
Maintainer: Steffen Neumann <sneumann@ipb-halle.de>
Depends: R (>= 2.10)
Suggests: xcms (>= 3.0.0), knitr
VignetteBuilder: knitr
ZipData: no
Description: Glandular trichomes are metabolic cell factories
with the capacity to produce large quantities of secondary metabolites.
Little is known about the connection between central carbon metabolism
and metabolic productivity for secondary metabolites in glandular trichomes.
To address this gap in our knowledge, we performed comparative metabolomics,
transcriptomics, proteomics and 13C-labeling of type VI glandular trichomes
and leaves from a cultivated (Solanum lycopersicum LA4024)
and a wild (Solanum habrochaites LA1777) tomato accession. Specific features
of glandular trichomes that drive the formation of secondary metabolites
could be identified. Tomato type VI trichomes are photosynthetic but acquire
their carbon essentially from leaf sucrose. The energy and reducing power
from photosynthesis are used to support the biosynthesis of secondary metabolites,
while the comparatively reduced Calvin-Benson-Bassham cycle activity
may be involved in recycling metabolic CO2. Glandular trichomes cope
with oxidative stress by producing high levels of polyunsaturated fatty acids,
oxylipins, and glutathione. Finally, distinct mechanisms are present
in glandular trichomes to increase the supply of precursors
for the isoprenoid pathways. Particularly, the citrate-malate shuttle
supplies cytosolic acetyl CoA and plastidic glycolysis and malic enzyme support
the formation of plastidic pyruvate. A model is proposed on how glandular trichomes
achieve high metabolic productivity.
biocViews: MassSpectrometryData, RepositoryData
License: CC0
URL: http://www.ebi.ac.uk/metabolights/MTBLS297,
https://github.com/sneumann/mtbls297
NeedsCompilation: no