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I want to the all-in-all search like EFI - Enzyme Similarity Tool function. I found when I took one query for easy-search in uniprot database, I will get thousands hits with different alignment location (from start to end aa). Then, I want do a further separation for theses hits, and I believe If I can extract these aligned structure for each hits to do further all-in-all search. I will get more precise separation for the secondary all-in-all search, which will be enough to point out there cognate substrates.
The aligned structure fragments I want to extract for further search:
The flow is below:
search homologous structure, and get hits
extract the aligned fragments (fragmented structure) to get the confined hits
all-in-all search for the confined hits ( which will hope to figure out the relationship between conserved structure and cognate substrate.
Thanks a lot, or there are alternative methods could help me solve this analysis thought.
The text was updated successfully, but these errors were encountered:
Wonderful software, thanks a lot.
I want to the all-in-all search like EFI - Enzyme Similarity Tool function. I found when I took one query for easy-search in uniprot database, I will get thousands hits with different alignment location (from start to end aa). Then, I want do a further separation for theses hits, and I believe If I can extract these aligned structure for each hits to do further all-in-all search. I will get more precise separation for the secondary all-in-all search, which will be enough to point out there cognate substrates.
![image](https://private-user-images.githubusercontent.com/24424074/321864019-b34417b4-7134-4df5-90a8-d15fcebb1484.png?jwt=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.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.tDTcx--Gfb1C_5TWyZ8qs9xZ62Y5l_Gc7bPZx1U5V_s)
The aligned structure fragments I want to extract for further search:
The flow is below:
Thanks a lot, or there are alternative methods could help me solve this analysis thought.
The text was updated successfully, but these errors were encountered: