drug_side_effects_1_importing_datasets.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "This notebook is used to look at the different datasets that are available and choose the one that could be best used to answer the goal which is predicting the side effects.\n",
    "\n",
    "Eventhough different datasets were imported, some of the datasets did not have enough information to merge with other dataset or there were other datasets which had more observations that I was interested to explore. Ultimately Liu dataset and two_sides dataset were used for all analyses and predictions"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Import libraries\n",
    "import pandas as pd\n",
    "from pandas import DataFrame\n",
    "import numpy as np\n",
    "pd.set_option('display.max_columns', None)  \n",
    "#pd.set_option('display.max_rows', None)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "1) UMLS_id = UMLS concept id as found on the drug label (UMLS - universal medical language system)\n",
    "\n",
    "2) concept_name = side effect\n",
    "\n",
    "3) detection_method = method of detection (NLP_indication/NLP_precondition/text_mention)\n",
    "the authors used NLP on drug label inserts to find the side effects for a particular drug\n",
    "\n",
    "4) concept_type = MedDRA concept type (LLT= lowest level term, PT= preferred term\n",
    "in few cases, the term is neither LLT nor PT\n",
    "NOTE: from medra.tsv file (SIDER website), PT covers all the different forma of a condition.\n",
    "eg. the PT, abdominal distension covers the different forms namely abdominal distension, distended abdomen, swollen abdomen, swelling abdomen or swelling abd\n",
    "\n",
    "5) UMLS_id_medra = UMLS concept id for MedDRA term\n",
    "\n",
    "6) medra_conceptname= MedDRA concept name\n",
    "\n",
    "IN meddra_all_indications.tsv.gz= all side effects found on the lables are given as LLT. there is atleast one PT for every LLT, but sometimes the PT is the same as the LLT"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Import the datafiles- snap dataset from stanford and SIDER database\n",
    "#MEDRA is a dictionary used by SIDER to extract side effects info from insert labels\n",
    "meddra_df = pd.read_table('data/meddra_all_indications.tsv', sep='\\t', \\\n",
    "                          names=[\"stitch_id\", \"UMLS_id\", \"detection_method\", \"concept_name\", \\\n",
    "                                 \"concept_type\", \"UMLS_id_medra\", \"medra_conceptname\"])\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
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       "    }\n",
       "\n",
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       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>stitch_id</th>\n",
       "      <th>UMLS_id</th>\n",
       "      <th>detection_method</th>\n",
       "      <th>concept_name</th>\n",
       "      <th>concept_type</th>\n",
       "      <th>UMLS_id_medra</th>\n",
       "      <th>medra_conceptname</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>C0015544</td>\n",
       "      <td>text_mention</td>\n",
       "      <td>Failure to Thrive</td>\n",
       "      <td>LLT</td>\n",
       "      <td>C0015544</td>\n",
       "      <td>Failure to thrive</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>C0015544</td>\n",
       "      <td>text_mention</td>\n",
       "      <td>Failure to Thrive</td>\n",
       "      <td>PT</td>\n",
       "      <td>C0015544</td>\n",
       "      <td>Failure to thrive</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>2</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>C0020615</td>\n",
       "      <td>text_mention</td>\n",
       "      <td>Hypoglycemia</td>\n",
       "      <td>LLT</td>\n",
       "      <td>C0020615</td>\n",
       "      <td>Hypoglycaemia</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>3</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>C0020615</td>\n",
       "      <td>text_mention</td>\n",
       "      <td>Hypoglycemia</td>\n",
       "      <td>PT</td>\n",
       "      <td>C0020615</td>\n",
       "      <td>Hypoglycaemia</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>4</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>C0022661</td>\n",
       "      <td>NLP_indication</td>\n",
       "      <td>Kidney Failure, Chronic</td>\n",
       "      <td>LLT</td>\n",
       "      <td>C0022661</td>\n",
       "      <td>Renal failure chronic</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "      stitch_id   UMLS_id detection_method             concept_name  \\\n",
       "0  CID100000085  C0015544     text_mention        Failure to Thrive   \n",
       "1  CID100000085  C0015544     text_mention        Failure to Thrive   \n",
       "2  CID100000085  C0020615     text_mention             Hypoglycemia   \n",
       "3  CID100000085  C0020615     text_mention             Hypoglycemia   \n",
       "4  CID100000085  C0022661   NLP_indication  Kidney Failure, Chronic   \n",
       "\n",
       "  concept_type UMLS_id_medra      medra_conceptname  \n",
       "0          LLT      C0015544      Failure to thrive  \n",
       "1           PT      C0015544      Failure to thrive  \n",
       "2          LLT      C0020615          Hypoglycaemia  \n",
       "3           PT      C0020615          Hypoglycaemia  \n",
       "4          LLT      C0022661  Renal failure chronic  "
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "meddra_df.head()\n",
    "#concept_name and medra_conceptname is indication for which a drug is used."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "#meddra_df[meddra_df.UMLS_id=='C0085393']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(30835, 7)"
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "meddra_df.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [],
   "source": [
    "#drop unnecessary columns\n",
    "meddra_df=meddra_df[meddra_df.concept_type=='PT']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [],
   "source": [
    "meddra_df=meddra_df.drop(['detection_method', 'concept_type', 'UMLS_id_medra', \\\n",
    "                         'medra_conceptname'], axis=1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
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       "\n",
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       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>stitch_id</th>\n",
       "      <th>UMLS_id</th>\n",
       "      <th>concept_name</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>C0015544</td>\n",
       "      <td>Failure to Thrive</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "      stitch_id   UMLS_id       concept_name\n",
       "1  CID100000085  C0015544  Failure to Thrive"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "meddra_df.head(1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "stitch_id       1437\n",
       "UMLS_id         2705\n",
       "concept_name    2705\n",
       "dtype: int64"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "meddra_df.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Use this only to merge with SNAP database since SNAP database has CID1... which is stitch_id1\n",
    "\n",
    "#meddra_all_label_indications.tsv -the only column that is extra in this\n",
    "#file is the source label which is the first column\n",
    "meddra_label_df =pd.read_table('data/meddra_all_label_indications.tsv', sep='\\t', \\\n",
    "                               names=[\"source_label\", \"stitch_id1\", \"stitch_id2\",\"UMLS_id\", \\\n",
    "                                      \"detection_method\", \"concept_name\", \\\n",
    "                                 \"concept_type\", \"UMLS_id_medra\", \"medra_conceptname\"])\n",
    "#What is the difference between stitch_id1 and \"stitch_id2\"?\n",
    "#there is only a difference of 1 digit- stitch_id1 is CID1... and stitch_id2 is CID0...\n",
    "#CIDs / CID0... - this is a stereo-specific compound, and the suffix is the \n",
    "#PubChem compound id.\n",
    "#CIDm / CID1... - this is a \"flat\" compound, i.e. with merged stereo-isomers\n",
    "#The suffix (without the leading \"1\") is the PubChem compound id."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "1) cells not needed : \n",
    "\n",
    "detection_method, UMLS_id\n",
    "\n",
    "2)UMLS id - concept unique identifier for the concept_name. for eg.if you search for C0016658\tUMLS_id, it will show concept_name associated with it is fracture.  (https://ncim.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20Metathesaurus&code=C00166580)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [],
   "source": [
    "#meddra.tsv has name of the side effect\n",
    "drug_side_effect=pd.read_table('data/meddra_all_label_se.tsv', sep='\\t', \\\n",
    "                          names=[\"source\", \"stitch_id1\", \"stitch_id2\", \"umls_id\", \"concept_type\", \"umls_idmeddra\", \\\n",
    "                                 \"side_effect\"])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_side_effect=drug_side_effect[drug_side_effect.concept_type=='PT']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
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       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>source</th>\n",
       "      <th>stitch_id1</th>\n",
       "      <th>stitch_id2</th>\n",
       "      <th>umls_id</th>\n",
       "      <th>concept_type</th>\n",
       "      <th>umls_idmeddra</th>\n",
       "      <th>side_effect</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>EMA/WC500020092.html</td>\n",
       "      <td>CID100216416</td>\n",
       "      <td>CID000216416</td>\n",
       "      <td>C0000737</td>\n",
       "      <td>PT</td>\n",
       "      <td>C0000737</td>\n",
       "      <td>Abdominal pain</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>2</td>\n",
       "      <td>EMA/WC500020092.html</td>\n",
       "      <td>CID100216416</td>\n",
       "      <td>CID000216416</td>\n",
       "      <td>C0000737</td>\n",
       "      <td>PT</td>\n",
       "      <td>C0687713</td>\n",
       "      <td>Gastrointestinal pain</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                 source    stitch_id1    stitch_id2   umls_id concept_type  \\\n",
       "1  EMA/WC500020092.html  CID100216416  CID000216416  C0000737           PT   \n",
       "2  EMA/WC500020092.html  CID100216416  CID000216416  C0000737           PT   \n",
       "\n",
       "  umls_idmeddra            side_effect  \n",
       "1      C0000737         Abdominal pain  \n",
       "2      C0687713  Gastrointestinal pain  "
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "drug_side_effect.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_side_effect=drug_side_effect.drop(['source', \"stitch_id2\", 'concept_type', 'umls_idmeddra'], axis=1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(2523626, 3)"
      ]
     },
     "execution_count": 16,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "drug_side_effect.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "stitch_id1     1430\n",
       "umls_id        5805\n",
       "side_effect    4251\n",
       "dtype: int64"
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "drug_side_effect.nunique()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "CID100002909, CID100003222, CID100003249, CID100010340, "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_names=pd.read_table('data/drug_names.tsv', sep='\\t', header=None, names=[\"stitch_code\", \"drug_name\"])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
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       "\n",
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       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>stitch_code</th>\n",
       "      <th>drug_name</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>CID100000085</td>\n",
       "      <td>carnitine</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>CID100000119</td>\n",
       "      <td>gamma-aminobutyric</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>2</td>\n",
       "      <td>CID100000137</td>\n",
       "      <td>5-aminolevulinic</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>3</td>\n",
       "      <td>CID100000143</td>\n",
       "      <td>leucovorin</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>4</td>\n",
       "      <td>CID100000146</td>\n",
       "      <td>5-methyltetrahydrofolate</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    stitch_code                 drug_name\n",
       "0  CID100000085                 carnitine\n",
       "1  CID100000119        gamma-aminobutyric\n",
       "2  CID100000137          5-aminolevulinic\n",
       "3  CID100000143                leucovorin\n",
       "4  CID100000146  5-methyltetrahydrofolate"
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "drug_names.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_names.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_names.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "# merge the drug names with meddra_df (meddra_all_indications data) on the stitch_id\n",
    "drug_meddra=pd.merge(drug_names, meddra_df, left_on=\"stitch_code\", right_on=\"stitch_id\", how='left')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#drop the stitch_id since it is same as stitch_code\n",
    "drug_meddra=drug_meddra.drop(columns=['stitch_id'])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra.head(3)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra.groupby('drug_name').stitch_code.count()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra.isnull().sum()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#merge drug_meddra with drug_side_effect\n",
    "drug_meddra_side_effect=pd.merge(drug_meddra, drug_side_effect, left_on='UMLS_id', right_on='umls_id', how='left')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra_side_effect.head(3)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_meddra_side_effect[drug_meddra_side_effect.UMLS_id=='C0085393']"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Drug ATC codes will be needed only to search using ATC codes in SIDER"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "drug_atc=pd.read_table('data/drug_atc.tsv', sep='\\t', header=None, names=[\"stitch_code\", \"atc_code\"])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#How many drugs?\n",
    "# Which drugs have the maximum side effects?\n",
    "#How many side effects for each drugs?"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#ATC code can be used to find the drug name from SIDER database\n",
    "#IS THERE ANOTHER DATABASE THAT CONNECTS ATC_CODE WITH DRUG NAME? -\n",
    "# https://www.genome.jp/kegg-bin/get_htext#E587\n",
    "drug_atc.head()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Biodecagon_stanford  or SNAP dataset"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "bio_decagon=pd.read_csv('data/bio-decagon-combo.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>STITCH 1</th>\n",
       "      <th>STITCH 2</th>\n",
       "      <th>Polypharmacy Side Effect</th>\n",
       "      <th>Side Effect Name</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>CID000002173</td>\n",
       "      <td>CID000003345</td>\n",
       "      <td>C0151714</td>\n",
       "      <td>hypermagnesemia</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>CID000002173</td>\n",
       "      <td>CID000003345</td>\n",
       "      <td>C0035344</td>\n",
       "      <td>retinopathy of prematurity</td>\n",
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      "text/plain": [
       "       STITCH 1      STITCH 2 Polypharmacy Side Effect  \\\n",
       "0  CID000002173  CID000003345                 C0151714   \n",
       "1  CID000002173  CID000003345                 C0035344   \n",
       "\n",
       "             Side Effect Name  \n",
       "0             hypermagnesemia  \n",
       "1  retinopathy of prematurity  "
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bio_decagon.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "bio_decagon.columns=['stitch_1', 'stitch_2', 'polypharmacy_side_effect', 'side_effect_name']\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "<class 'pandas.core.frame.DataFrame'>\n",
      "RangeIndex: 4649441 entries, 0 to 4649440\n",
      "Data columns (total 4 columns):\n",
      "stitch_1                    object\n",
      "stitch_2                    object\n",
      "polypharmacy_side_effect    object\n",
      "side_effect_name            object\n",
      "dtypes: object(4)\n",
      "memory usage: 141.9+ MB\n"
     ]
    }
   ],
   "source": [
    "bio_decagon.info()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "bio_decagon.stitch_1.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#merge bio_decagon with drug_names"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 30,
   "metadata": {},
   "outputs": [
    {
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       "      <th>SUB404</th>\n",
       "      <th>SUB405</th>\n",
       "      <th>SUB406</th>\n",
       "      <th>SUB407</th>\n",
       "      <th>SUB408</th>\n",
       "      <th>SUB409</th>\n",
       "      <th>SUB410</th>\n",
       "      <th>SUB411</th>\n",
       "      <th>SUB412</th>\n",
       "      <th>SUB413</th>\n",
       "      <th>SUB414</th>\n",
       "      <th>SUB415</th>\n",
       "      <th>SUB416</th>\n",
       "      <th>SUB417</th>\n",
       "      <th>SUB418</th>\n",
       "      <th>SUB419</th>\n",
       "      <th>SUB420</th>\n",
       "      <th>SUB421</th>\n",
       "      <th>SUB422</th>\n",
       "      <th>SUB423</th>\n",
       "      <th>SUB424</th>\n",
       "      <th>SUB425</th>\n",
       "      <th>SUB426</th>\n",
       "      <th>SUB427</th>\n",
       "      <th>SUB428</th>\n",
       "      <th>SUB429</th>\n",
       "      <th>SUB430</th>\n",
       "      <th>SUB431</th>\n",
       "      <th>SUB432</th>\n",
       "      <th>SUB433</th>\n",
       "      <th>SUB434</th>\n",
       "      <th>SUB435</th>\n",
       "      <th>SUB436</th>\n",
       "      <th>SUB437</th>\n",
       "      <th>SUB438</th>\n",
       "      <th>SUB439</th>\n",
       "      <th>SUB440</th>\n",
       "      <th>SUB441</th>\n",
       "      <th>SUB442</th>\n",
       "      <th>SUB443</th>\n",
       "      <th>SUB444</th>\n",
       "      <th>SUB445</th>\n",
       "      <th>SUB446</th>\n",
       "      <th>SUB447</th>\n",
       "      <th>SUB448</th>\n",
       "      <th>SUB449</th>\n",
       "      <th>SUB450</th>\n",
       "      <th>SUB451</th>\n",
       "      <th>SUB452</th>\n",
       "      <th>SUB453</th>\n",
       "      <th>SUB454</th>\n",
       "      <th>SUB455</th>\n",
       "      <th>SUB456</th>\n",
       "      <th>SUB457</th>\n",
       "      <th>SUB458</th>\n",
       "      <th>SUB459</th>\n",
       "      <th>SUB460</th>\n",
       "      <th>SUB461</th>\n",
       "      <th>SUB462</th>\n",
       "      <th>SUB463</th>\n",
       "      <th>SUB464</th>\n",
       "      <th>SUB465</th>\n",
       "      <th>SUB466</th>\n",
       "      <th>SUB467</th>\n",
       "      <th>SUB468</th>\n",
       "      <th>SUB469</th>\n",
       "      <th>SUB470</th>\n",
       "      <th>SUB471</th>\n",
       "      <th>SUB472</th>\n",
       "      <th>SUB473</th>\n",
       "      <th>SUB474</th>\n",
       "      <th>SUB475</th>\n",
       "      <th>SUB476</th>\n",
       "      <th>SUB477</th>\n",
       "      <th>SUB478</th>\n",
       "      <th>SUB479</th>\n",
       "      <th>SUB480</th>\n",
       "      <th>SUB481</th>\n",
       "      <th>SUB482</th>\n",
       "      <th>SUB483</th>\n",
       "      <th>SUB484</th>\n",
       "      <th>SUB485</th>\n",
       "      <th>SUB486</th>\n",
       "      <th>SUB487</th>\n",
       "      <th>SUB488</th>\n",
       "      <th>SUB489</th>\n",
       "      <th>SUB490</th>\n",
       "      <th>SUB491</th>\n",
       "      <th>SUB492</th>\n",
       "      <th>SUB493</th>\n",
       "      <th>SUB494</th>\n",
       "      <th>SUB495</th>\n",
       "      <th>SUB496</th>\n",
       "      <th>SUB497</th>\n",
       "      <th>SUB498</th>\n",
       "      <th>SUB499</th>\n",
       "      <th>SUB500</th>\n",
       "      <th>SUB501</th>\n",
       "      <th>SUB502</th>\n",
       "      <th>SUB503</th>\n",
       "      <th>SUB504</th>\n",
       "      <th>SUB505</th>\n",
       "      <th>SUB506</th>\n",
       "      <th>SUB507</th>\n",
       "      <th>SUB508</th>\n",
       "      <th>SUB509</th>\n",
       "      <th>SUB510</th>\n",
       "      <th>SUB511</th>\n",
       "      <th>SUB512</th>\n",
       "      <th>SUB513</th>\n",
       "      <th>SUB514</th>\n",
       "      <th>SUB515</th>\n",
       "      <th>SUB516</th>\n",
       "      <th>SUB517</th>\n",
       "      <th>SUB518</th>\n",
       "      <th>SUB519</th>\n",
       "      <th>SUB520</th>\n",
       "      <th>SUB521</th>\n",
       "      <th>SUB522</th>\n",
       "      <th>SUB523</th>\n",
       "      <th>SUB524</th>\n",
       "      <th>SUB525</th>\n",
       "      <th>SUB526</th>\n",
       "      <th>SUB527</th>\n",
       "      <th>SUB528</th>\n",
       "      <th>SUB529</th>\n",
       "      <th>SUB530</th>\n",
       "      <th>SUB531</th>\n",
       "      <th>SUB532</th>\n",
       "      <th>SUB533</th>\n",
       "      <th>SUB534</th>\n",
       "      <th>SUB535</th>\n",
       "      <th>SUB536</th>\n",
       "      <th>SUB537</th>\n",
       "      <th>SUB538</th>\n",
       "      <th>SUB539</th>\n",
       "      <th>SUB540</th>\n",
       "      <th>SUB541</th>\n",
       "      <th>SUB542</th>\n",
       "      <th>SUB543</th>\n",
       "      <th>SUB544</th>\n",
       "      <th>SUB545</th>\n",
       "      <th>SUB546</th>\n",
       "      <th>SUB547</th>\n",
       "      <th>SUB548</th>\n",
       "      <th>SUB549</th>\n",
       "      <th>SUB550</th>\n",
       "      <th>SUB551</th>\n",
       "      <th>SUB552</th>\n",
       "      <th>SUB553</th>\n",
       "      <th>SUB554</th>\n",
       "      <th>SUB555</th>\n",
       "      <th>SUB556</th>\n",
       "      <th>SUB557</th>\n",
       "      <th>SUB558</th>\n",
       "      <th>SUB559</th>\n",
       "      <th>SUB560</th>\n",
       "      <th>SUB561</th>\n",
       "      <th>SUB562</th>\n",
       "      <th>SUB563</th>\n",
       "      <th>SUB564</th>\n",
       "      <th>SUB565</th>\n",
       "      <th>SUB566</th>\n",
       "      <th>SUB567</th>\n",
       "      <th>SUB568</th>\n",
       "      <th>SUB569</th>\n",
       "      <th>SUB570</th>\n",
       "      <th>SUB571</th>\n",
       "      <th>SUB572</th>\n",
       "      <th>SUB573</th>\n",
       "      <th>SUB574</th>\n",
       "      <th>SUB575</th>\n",
       "      <th>SUB576</th>\n",
       "      <th>SUB577</th>\n",
       "      <th>SUB578</th>\n",
       "      <th>SUB579</th>\n",
       "      <th>SUB580</th>\n",
       "      <th>SUB581</th>\n",
       "      <th>SUB582</th>\n",
       "      <th>SUB583</th>\n",
       "      <th>SUB584</th>\n",
       "      <th>SUB585</th>\n",
       "      <th>SUB586</th>\n",
       "      <th>SUB587</th>\n",
       "      <th>SUB588</th>\n",
       "      <th>SUB589</th>\n",
       "      <th>SUB590</th>\n",
       "      <th>SUB591</th>\n",
       "      <th>SUB592</th>\n",
       "      <th>SUB593</th>\n",
       "      <th>SUB594</th>\n",
       "      <th>SUB595</th>\n",
       "      <th>SUB596</th>\n",
       "      <th>SUB597</th>\n",
       "      <th>SUB598</th>\n",
       "      <th>SUB599</th>\n",
       "      <th>SUB600</th>\n",
       "      <th>SUB601</th>\n",
       "      <th>SUB602</th>\n",
       "      <th>SUB603</th>\n",
       "      <th>SUB604</th>\n",
       "      <th>SUB605</th>\n",
       "      <th>SUB606</th>\n",
       "      <th>SUB607</th>\n",
       "      <th>SUB608</th>\n",
       "      <th>SUB609</th>\n",
       "      <th>SUB610</th>\n",
       "      <th>SUB611</th>\n",
       "      <th>SUB612</th>\n",
       "      <th>SUB613</th>\n",
       "      <th>SUB614</th>\n",
       "      <th>SUB615</th>\n",
       "      <th>SUB616</th>\n",
       "      <th>SUB617</th>\n",
       "      <th>SUB618</th>\n",
       "      <th>SUB619</th>\n",
       "      <th>SUB620</th>\n",
       "      <th>SUB621</th>\n",
       "      <th>SUB622</th>\n",
       "      <th>SUB623</th>\n",
       "      <th>SUB624</th>\n",
       "      <th>SUB625</th>\n",
       "      <th>SUB626</th>\n",
       "      <th>SUB627</th>\n",
       "      <th>SUB628</th>\n",
       "      <th>SUB629</th>\n",
       "      <th>SUB630</th>\n",
       "      <th>SUB631</th>\n",
       "      <th>SUB632</th>\n",
       "      <th>SUB633</th>\n",
       "      <th>SUB634</th>\n",
       "      <th>SUB635</th>\n",
       "      <th>SUB636</th>\n",
       "      <th>SUB637</th>\n",
       "      <th>SUB638</th>\n",
       "      <th>SUB639</th>\n",
       "      <th>SUB640</th>\n",
       "      <th>SUB641</th>\n",
       "      <th>SUB642</th>\n",
       "      <th>SUB643</th>\n",
       "      <th>SUB644</th>\n",
       "      <th>SUB645</th>\n",
       "      <th>SUB646</th>\n",
       "      <th>SUB647</th>\n",
       "      <th>SUB648</th>\n",
       "      <th>SUB649</th>\n",
       "      <th>SUB650</th>\n",
       "      <th>SUB651</th>\n",
       "      <th>SUB652</th>\n",
       "      <th>SUB653</th>\n",
       "      <th>SUB654</th>\n",
       "      <th>SUB655</th>\n",
       "      <th>SUB656</th>\n",
       "      <th>SUB657</th>\n",
       "      <th>SUB658</th>\n",
       "      <th>SUB659</th>\n",
       "      <th>SUB660</th>\n",
       "      <th>SUB661</th>\n",
       "      <th>SUB662</th>\n",
       "      <th>SUB663</th>\n",
       "      <th>SUB664</th>\n",
       "      <th>SUB665</th>\n",
       "      <th>SUB666</th>\n",
       "      <th>SUB667</th>\n",
       "      <th>SUB668</th>\n",
       "      <th>SUB669</th>\n",
       "      <th>SUB670</th>\n",
       "      <th>SUB671</th>\n",
       "      <th>SUB672</th>\n",
       "      <th>SUB673</th>\n",
       "      <th>SUB674</th>\n",
       "      <th>SUB675</th>\n",
       "      <th>SUB676</th>\n",
       "      <th>SUB677</th>\n",
       "      <th>SUB678</th>\n",
       "      <th>SUB679</th>\n",
       "      <th>SUB680</th>\n",
       "      <th>SUB681</th>\n",
       "      <th>SUB682</th>\n",
       "      <th>SUB683</th>\n",
       "      <th>SUB684</th>\n",
       "      <th>SUB685</th>\n",
       "      <th>SUB686</th>\n",
       "      <th>SUB687</th>\n",
       "      <th>SUB688</th>\n",
       "      <th>SUB689</th>\n",
       "      <th>SUB690</th>\n",
       "      <th>SUB691</th>\n",
       "      <th>SUB692</th>\n",
       "      <th>SUB693</th>\n",
       "      <th>SUB694</th>\n",
       "      <th>SUB695</th>\n",
       "      <th>SUB696</th>\n",
       "      <th>SUB697</th>\n",
       "      <th>SUB698</th>\n",
       "      <th>SUB699</th>\n",
       "      <th>SUB700</th>\n",
       "      <th>SUB701</th>\n",
       "      <th>SUB702</th>\n",
       "      <th>SUB703</th>\n",
       "      <th>SUB704</th>\n",
       "      <th>SUB705</th>\n",
       "      <th>SUB706</th>\n",
       "      <th>SUB707</th>\n",
       "      <th>SUB708</th>\n",
       "      <th>SUB709</th>\n",
       "      <th>SUB710</th>\n",
       "      <th>SUB711</th>\n",
       "      <th>SUB712</th>\n",
       "      <th>SUB713</th>\n",
       "      <th>SUB714</th>\n",
       "      <th>SUB715</th>\n",
       "      <th>SUB716</th>\n",
       "      <th>SUB717</th>\n",
       "      <th>SUB718</th>\n",
       "      <th>SUB719</th>\n",
       "      <th>SUB720</th>\n",
       "      <th>SUB721</th>\n",
       "      <th>SUB722</th>\n",
       "      <th>SUB723</th>\n",
       "      <th>SUB724</th>\n",
       "      <th>SUB725</th>\n",
       "      <th>SUB726</th>\n",
       "      <th>SUB727</th>\n",
       "      <th>SUB728</th>\n",
       "      <th>SUB729</th>\n",
       "      <th>SUB730</th>\n",
       "      <th>SUB731</th>\n",
       "      <th>SUB732</th>\n",
       "      <th>SUB733</th>\n",
       "      <th>SUB734</th>\n",
       "      <th>SUB735</th>\n",
       "      <th>SUB736</th>\n",
       "      <th>SUB737</th>\n",
       "      <th>SUB738</th>\n",
       "      <th>SUB739</th>\n",
       "      <th>SUB740</th>\n",
       "      <th>SUB741</th>\n",
       "      <th>SUB742</th>\n",
       "      <th>SUB743</th>\n",
       "      <th>SUB744</th>\n",
       "      <th>SUB745</th>\n",
       "      <th>SUB746</th>\n",
       "      <th>SUB747</th>\n",
       "      <th>SUB748</th>\n",
       "      <th>SUB749</th>\n",
       "      <th>SUB750</th>\n",
       "      <th>SUB751</th>\n",
       "      <th>SUB752</th>\n",
       "      <th>SUB753</th>\n",
       "      <th>SUB754</th>\n",
       "      <th>SUB755</th>\n",
       "      <th>SUB756</th>\n",
       "      <th>SUB757</th>\n",
       "      <th>SUB758</th>\n",
       "      <th>SUB759</th>\n",
       "      <th>SUB760</th>\n",
       "      <th>SUB761</th>\n",
       "      <th>SUB762</th>\n",
       "      <th>SUB763</th>\n",
       "      <th>SUB764</th>\n",
       "      <th>SUB765</th>\n",
       "      <th>SUB766</th>\n",
       "      <th>SUB767</th>\n",
       "      <th>SUB768</th>\n",
       "      <th>SUB769</th>\n",
       "      <th>SUB770</th>\n",
       "      <th>SUB771</th>\n",
       "      <th>SUB772</th>\n",
       "      <th>SUB773</th>\n",
       "      <th>SUB774</th>\n",
       "      <th>SUB775</th>\n",
       "      <th>SUB776</th>\n",
       "      <th>SUB777</th>\n",
       "      <th>SUB778</th>\n",
       "      <th>SUB779</th>\n",
       "      <th>SUB780</th>\n",
       "      <th>SUB781</th>\n",
       "      <th>SUB782</th>\n",
       "      <th>SUB783</th>\n",
       "      <th>SUB784</th>\n",
       "      <th>SUB785</th>\n",
       "      <th>SUB786</th>\n",
       "      <th>SUB787</th>\n",
       "      <th>SUB788</th>\n",
       "      <th>SUB789</th>\n",
       "      <th>SUB790</th>\n",
       "      <th>SUB791</th>\n",
       "      <th>SUB792</th>\n",
       "      <th>SUB793</th>\n",
       "      <th>SUB794</th>\n",
       "      <th>SUB795</th>\n",
       "      <th>SUB796</th>\n",
       "      <th>SUB797</th>\n",
       "      <th>SUB798</th>\n",
       "      <th>SUB799</th>\n",
       "      <th>SUB800</th>\n",
       "      <th>SUB801</th>\n",
       "      <th>SUB802</th>\n",
       "      <th>SUB803</th>\n",
       "      <th>SUB804</th>\n",
       "      <th>SUB805</th>\n",
       "      <th>SUB806</th>\n",
       "      <th>SUB807</th>\n",
       "      <th>SUB808</th>\n",
       "      <th>SUB809</th>\n",
       "      <th>SUB810</th>\n",
       "      <th>SUB811</th>\n",
       "      <th>SUB812</th>\n",
       "      <th>SUB813</th>\n",
       "      <th>SUB814</th>\n",
       "      <th>SUB815</th>\n",
       "      <th>SUB816</th>\n",
       "      <th>SUB817</th>\n",
       "      <th>SUB818</th>\n",
       "      <th>SUB819</th>\n",
       "      <th>SUB820</th>\n",
       "      <th>SUB821</th>\n",
       "      <th>SUB822</th>\n",
       "      <th>SUB823</th>\n",
       "      <th>SUB824</th>\n",
       "      <th>SUB825</th>\n",
       "      <th>SUB826</th>\n",
       "      <th>SUB827</th>\n",
       "      <th>SUB828</th>\n",
       "      <th>SUB829</th>\n",
       "      <th>SUB830</th>\n",
       "      <th>SUB831</th>\n",
       "      <th>SUB832</th>\n",
       "      <th>SUB833</th>\n",
       "      <th>SUB834</th>\n",
       "      <th>SUB835</th>\n",
       "      <th>SUB836</th>\n",
       "      <th>SUB837</th>\n",
       "      <th>SUB838</th>\n",
       "      <th>SUB839</th>\n",
       "      <th>SUB840</th>\n",
       "      <th>SUB841</th>\n",
       "      <th>SUB842</th>\n",
       "      <th>SUB843</th>\n",
       "      <th>SUB844</th>\n",
       "      <th>SUB845</th>\n",
       "      <th>SUB846</th>\n",
       "      <th>SUB847</th>\n",
       "      <th>SUB848</th>\n",
       "      <th>SUB849</th>\n",
       "      <th>SUB850</th>\n",
       "      <th>SUB851</th>\n",
       "      <th>SUB852</th>\n",
       "      <th>SUB853</th>\n",
       "      <th>SUB854</th>\n",
       "      <th>SUB855</th>\n",
       "      <th>SUB856</th>\n",
       "      <th>SUB857</th>\n",
       "      <th>SUB858</th>\n",
       "      <th>SUB859</th>\n",
       "      <th>SUB860</th>\n",
       "      <th>SUB861</th>\n",
       "      <th>SUB862</th>\n",
       "      <th>SUB863</th>\n",
       "      <th>SUB864</th>\n",
       "      <th>SUB865</th>\n",
       "      <th>SUB866</th>\n",
       "      <th>SUB867</th>\n",
       "      <th>SUB868</th>\n",
       "      <th>SUB869</th>\n",
       "      <th>SUB870</th>\n",
       "      <th>SUB871</th>\n",
       "      <th>SUB872</th>\n",
       "      <th>SUB873</th>\n",
       "      <th>SUB874</th>\n",
       "      <th>SUB875</th>\n",
       "      <th>SUB876</th>\n",
       "      <th>SUB877</th>\n",
       "      <th>SUB878</th>\n",
       "      <th>SUB879</th>\n",
       "      <th>SUB880</th>\n",
       "      <th>SUB881</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>carnitine</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>GABA</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>1</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>2</td>\n",
       "      <td>delta-aminolevulinic acid</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>3</td>\n",
       "      <td>leucovorin</td>\n",
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       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>1</td>\n",
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       "      <td>1</td>\n",
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       "      <td>1</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>4</td>\n",
       "      <td>PGE2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                  Unnamed: 0  SUB1  SUB2  SUB3  SUB4  SUB5  SUB6  SUB7  SUB8  \\\n",
       "0                  carnitine     1     1     1     0     0     0     0     0   \n",
       "1                       GABA     1     1     0     0     0     0     0     0   \n",
       "2  delta-aminolevulinic acid     1     1     0     0     0     0     0     0   \n",
       "3                 leucovorin     1     1     1     0     0     0     0     0   \n",
       "4                       PGE2     1     1     1     1     0     0     0     0   \n",
       "\n",
       "   SUB9  SUB10  SUB11  SUB12  SUB13  SUB14  SUB15  SUB16  SUB17  SUB18  SUB19  \\\n",
       "0     0      1      1      0      0      0      1      0      0      0      1   \n",
       "1     0      1      1      0      0      0      1      0      0      0      1   \n",
       "2     0      1      1      0      0      0      1      0      0      0      1   \n",
       "3     0      1      1      1      1      0      1      1      1      0      1   \n",
       "4     0      1      1      1      1      0      0      0      0      0      1   \n",
       "\n",
       "   SUB20  SUB21  SUB22  SUB23  SUB24  SUB25  SUB26  SUB27  SUB28  SUB29  \\\n",
       "0      1      0      0      0      0      0      0      0      0      0   \n",
       "1      1      0      0      0      0      0      0      0      0      0   \n",
       "2      1      0      0      0      0      0      0      0      0      0   \n",
       "3      1      1      0      0      0      0      0      0      0      0   \n",
       "4      1      1      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB30  SUB31  SUB32  SUB33  SUB34  SUB35  SUB36  SUB37  SUB38  SUB39  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB40  SUB41  SUB42  SUB43  SUB44  SUB45  SUB46  SUB47  SUB48  SUB49  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB50  SUB51  SUB52  SUB53  SUB54  SUB55  SUB56  SUB57  SUB58  SUB59  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB60  SUB61  SUB62  SUB63  SUB64  SUB65  SUB66  SUB67  SUB68  SUB69  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB70  SUB71  SUB72  SUB73  SUB74  SUB75  SUB76  SUB77  SUB78  SUB79  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB80  SUB81  SUB82  SUB83  SUB84  SUB85  SUB86  SUB87  SUB88  SUB89  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB90  SUB91  SUB92  SUB93  SUB94  SUB95  SUB96  SUB97  SUB98  SUB99  \\\n",
       "0      0      0      0      0      0      0      0      0      0      0   \n",
       "1      0      0      0      0      0      0      0      0      0      0   \n",
       "2      0      0      0      0      0      0      0      0      0      0   \n",
       "3      0      0      0      0      0      0      0      0      0      0   \n",
       "4      0      0      0      0      0      0      0      0      0      0   \n",
       "\n",
       "   SUB100  SUB101  SUB102  SUB103  SUB104  SUB105  SUB106  SUB107  SUB108  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB109  SUB110  SUB111  SUB112  SUB113  SUB114  SUB115  SUB116  SUB117  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB118  SUB119  SUB120  SUB121  SUB122  SUB123  SUB124  SUB125  SUB126  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB127  SUB128  SUB129  SUB130  SUB131  SUB132  SUB133  SUB134  SUB135  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB136  SUB137  SUB138  SUB139  SUB140  SUB141  SUB142  SUB143  SUB144  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       1   \n",
       "\n",
       "   SUB145  SUB146  SUB147  SUB148  SUB149  SUB150  SUB151  SUB152  SUB153  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       1       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB154  SUB155  SUB156  SUB157  SUB158  SUB159  SUB160  SUB161  SUB162  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB163  SUB164  SUB165  SUB166  SUB167  SUB168  SUB169  SUB170  SUB171  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB172  SUB173  SUB174  SUB175  SUB176  SUB177  SUB178  SUB179  SUB180  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       1       1   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB181  SUB182  SUB183  SUB184  SUB185  SUB186  SUB187  SUB188  SUB189  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       1       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB190  SUB191  SUB192  SUB193  SUB194  SUB195  SUB196  SUB197  SUB198  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       1       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB199  SUB200  SUB201  SUB202  SUB203  SUB204  SUB205  SUB206  SUB207  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB208  SUB209  SUB210  SUB211  SUB212  SUB213  SUB214  SUB215  SUB216  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB217  SUB218  SUB219  SUB220  SUB221  SUB222  SUB223  SUB224  SUB225  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB226  SUB227  SUB228  SUB229  SUB230  SUB231  SUB232  SUB233  SUB234  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB235  SUB236  SUB237  SUB238  SUB239  SUB240  SUB241  SUB242  SUB243  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB244  SUB245  SUB246  SUB247  SUB248  SUB249  SUB250  SUB251  SUB252  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       1       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB253  SUB254  SUB255  SUB256  SUB257  SUB258  SUB259  SUB260  SUB261  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       1       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB262  SUB263  SUB264  SUB265  SUB266  SUB267  SUB268  SUB269  SUB270  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB271  SUB272  SUB273  SUB274  SUB275  SUB276  SUB277  SUB278  SUB279  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB280  SUB281  SUB282  SUB283  SUB284  SUB285  SUB286  SUB287  SUB288  \\\n",
       "0       0       0       0       0       1       1       1       1       0   \n",
       "1       0       0       0       0       1       1       1       1       0   \n",
       "2       0       0       0       0       1       1       1       1       0   \n",
       "3       0       0       0       0       1       1       1       1       0   \n",
       "4       0       0       0       0       1       1       0       1       0   \n",
       "\n",
       "   SUB289  SUB290  SUB291  SUB292  SUB293  SUB294  SUB295  SUB296  SUB297  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB298  SUB299  SUB300  SUB301  SUB302  SUB303  SUB304  SUB305  SUB306  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       1       0       0       0       0       0       0   \n",
       "2       0       0       1       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB307  SUB308  SUB309  SUB310  SUB311  SUB312  SUB313  SUB314  SUB315  \\\n",
       "0       0       0       1       0       0       0       0       0       0   \n",
       "1       0       0       1       0       0       0       0       0       0   \n",
       "2       0       0       1       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       0       0       0       0   \n",
       "4       0       0       1       0       0       0       0       0       0   \n",
       "\n",
       "   SUB316  SUB317  SUB318  SUB319  SUB320  SUB321  SUB322  SUB323  SUB324  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB325  SUB326  SUB327  SUB328  SUB329  SUB330  SUB331  SUB332  SUB333  \\\n",
       "0       0       0       0       0       0       0       0       0       1   \n",
       "1       0       0       0       0       0       0       0       0       1   \n",
       "2       0       0       0       0       0       0       0       0       1   \n",
       "3       0       0       0       0       0       0       0       0       1   \n",
       "4       0       0       0       0       0       0       0       0       1   \n",
       "\n",
       "   SUB334  SUB335  SUB336  SUB337  SUB338  SUB339  SUB340  SUB341  SUB342  \\\n",
       "0       0       0       0       0       0       0       1       0       1   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       1   \n",
       "3       1       0       0       0       0       1       0       1       0   \n",
       "4       1       0       1       0       0       0       1       0       1   \n",
       "\n",
       "   SUB343  SUB344  SUB345  SUB346  SUB347  SUB348  SUB349  SUB350  SUB351  \\\n",
       "0       0       0       1       1       1       0       0       0       0   \n",
       "1       0       0       1       1       0       0       0       0       0   \n",
       "2       0       0       1       1       0       0       0       0       0   \n",
       "3       0       0       1       1       0       0       0       0       0   \n",
       "4       0       0       1       0       1       0       0       0       0   \n",
       "\n",
       "   SUB352  SUB353  SUB354  SUB355  SUB356  SUB357  SUB358  SUB359  SUB360  \\\n",
       "0       1       1       0       0       0       0       0       0       0   \n",
       "1       1       1       0       0       0       0       0       0       0   \n",
       "2       1       1       0       0       0       0       0       0       0   \n",
       "3       1       1       0       0       1       1       0       0       0   \n",
       "4       0       1       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB361  SUB362  SUB363  SUB364  SUB365  SUB366  SUB367  SUB368  SUB369  \\\n",
       "0       0       0       0       0       0       1       1       0       0   \n",
       "1       0       0       0       0       0       1       0       0       0   \n",
       "2       0       0       0       0       0       1       0       0       0   \n",
       "3       0       0       0       0       0       1       1       0       0   \n",
       "4       0       0       0       0       0       0       1       0       0   \n",
       "\n",
       "   SUB370  SUB371  SUB372  SUB373  SUB374  SUB375  SUB376  SUB377  SUB378  \\\n",
       "0       0       0       0       0       0       1       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       1       1       0       0       0       1       1       1   \n",
       "4       0       0       0       0       0       1       0       0       0   \n",
       "\n",
       "   SUB379  SUB380  SUB381  SUB382  SUB383  SUB384  SUB385  SUB386  SUB387  \\\n",
       "0       0       0       1       0       0       0       0       0       0   \n",
       "1       0       0       1       0       0       0       0       0       0   \n",
       "2       0       0       1       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       0       1       0       0   \n",
       "4       0       0       1       0       0       0       0       0       0   \n",
       "\n",
       "   SUB388  SUB389  SUB390  SUB391  SUB392  SUB393  SUB394  SUB395  SUB396  \\\n",
       "0       0       0       0       1       1       0       0       0       0   \n",
       "1       0       0       0       0       0       0       1       0       0   \n",
       "2       0       0       0       0       0       0       1       0       0   \n",
       "3       0       0       0       1       1       1       1       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB397  SUB398  SUB399  SUB400  SUB401  SUB402  SUB403  SUB404  SUB405  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB406  SUB407  SUB408  SUB409  SUB410  SUB411  SUB412  SUB413  SUB414  \\\n",
       "0       0       1       0       0       0       0       0       0       0   \n",
       "1       0       1       0       0       0       0       0       0       0   \n",
       "2       0       1       0       0       0       0       0       0       0   \n",
       "3       0       1       0       0       0       0       0       0       0   \n",
       "4       0       1       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB415  SUB416  SUB417  SUB418  SUB419  SUB420  SUB421  SUB422  SUB423  \\\n",
       "0       0       0       0       0       0       0       1       0       0   \n",
       "1       0       0       0       0       0       0       1       0       0   \n",
       "2       0       0       0       0       0       0       1       0       0   \n",
       "3       0       0       1       0       1       0       1       0       0   \n",
       "4       0       0       1       0       0       0       1       0       0   \n",
       "\n",
       "   SUB424  SUB425  SUB426  SUB427  SUB428  SUB429  SUB430  SUB431  SUB432  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       1       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB433  SUB434  SUB435  SUB436  SUB437  SUB438  SUB439  SUB440  SUB441  \\\n",
       "0       0       0       0       0       0       0       0       0       1   \n",
       "1       0       0       0       0       0       0       0       0       1   \n",
       "2       1       0       0       0       0       0       0       0       1   \n",
       "3       0       0       1       0       0       1       0       1       1   \n",
       "4       1       0       1       0       0       0       0       0       1   \n",
       "\n",
       "   SUB442  SUB443  SUB444  SUB445  SUB446  SUB447  SUB448  SUB449  SUB450  \\\n",
       "0       0       0       1       0       0       0       0       0       0   \n",
       "1       0       0       1       0       0       0       0       0       0   \n",
       "2       0       0       1       0       0       0       0       0       0   \n",
       "3       1       0       1       0       0       1       0       1       1   \n",
       "4       1       0       1       0       0       1       0       0       0   \n",
       "\n",
       "   SUB451  SUB452  SUB453  SUB454  SUB455  SUB456  SUB457  SUB458  SUB459  \\\n",
       "0       0       0       1       0       0       0       0       0       0   \n",
       "1       0       0       1       0       0       0       0       0       0   \n",
       "2       0       0       1       0       0       0       0       0       0   \n",
       "3       1       1       1       1       0       0       0       0       0   \n",
       "4       0       0       1       0       0       0       0       0       0   \n",
       "\n",
       "   SUB460  SUB461  SUB462  SUB463  SUB464  SUB465  SUB466  SUB467  SUB468  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       1       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB469  SUB470  SUB471  SUB472  SUB473  SUB474  SUB475  SUB476  SUB477  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB478  SUB479  SUB480  SUB481  SUB482  SUB483  SUB484  SUB485  SUB486  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB487  SUB488  SUB489  SUB490  SUB491  SUB492  SUB493  SUB494  SUB495  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       1       0       0       1       0       0       1       0   \n",
       "4       0       0       0       0       1       0       0       0       0   \n",
       "\n",
       "   SUB496  SUB497  SUB498  SUB499  SUB500  SUB501  SUB502  SUB503  SUB504  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       1       0       0       0       0       0       0       1       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB505  SUB506  SUB507  SUB508  SUB509  SUB510  SUB511  SUB512  SUB513  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB514  SUB515  SUB516  SUB517  SUB518  SUB519  SUB520  SUB521  SUB522  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       1       0       0       1       1       0   \n",
       "4       0       0       0       1       0       0       0       0       0   \n",
       "\n",
       "   SUB523  SUB524  SUB525  SUB526  SUB527  SUB528  SUB529  SUB530  SUB531  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       1       0       0   \n",
       "2       0       0       0       0       0       0       1       0       0   \n",
       "3       0       0       1       0       0       0       1       0       0   \n",
       "4       0       0       1       0       0       0       0       0       0   \n",
       "\n",
       "   SUB532  SUB533  SUB534  SUB535  SUB536  SUB537  SUB538  SUB539  SUB540  \\\n",
       "0       0       0       0       0       1       0       0       0       0   \n",
       "1       0       0       0       0       1       0       0       0       0   \n",
       "2       0       0       0       0       1       1       0       0       0   \n",
       "3       0       0       0       0       1       1       0       0       0   \n",
       "4       0       0       0       0       1       0       0       0       0   \n",
       "\n",
       "   SUB541  SUB542  SUB543  SUB544  SUB545  SUB546  SUB547  SUB548  SUB549  \\\n",
       "0       1       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       1       0       0       0       0       1       1       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB550  SUB551  SUB552  SUB553  SUB554  SUB555  SUB556  SUB557  SUB558  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       1       0       0       1       1       0       0       1       0   \n",
       "4       0       0       0       0       0       0       0       1       0   \n",
       "\n",
       "   SUB559  SUB560  SUB561  SUB562  SUB563  SUB564  SUB565  SUB566  SUB567  \\\n",
       "0       0       0       0       0       0       0       0       0       1   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       0       1       0       1   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB568  SUB569  SUB570  SUB571  SUB572  SUB573  SUB574  SUB575  SUB576  \\\n",
       "0       0       0       0       0       1       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       1       1       0       0       0       0       0   \n",
       "4       0       0       0       0       1       0       1       0       0   \n",
       "\n",
       "   SUB577  SUB578  SUB579  SUB580  SUB581  SUB582  SUB583  SUB584  SUB585  \\\n",
       "0       0       0       0       1       0       1       0       0       0   \n",
       "1       0       0       0       1       0       0       0       0       0   \n",
       "2       0       0       0       1       0       0       1       0       0   \n",
       "3       0       0       1       1       0       0       1       0       1   \n",
       "4       0       0       0       1       0       1       1       0       0   \n",
       "\n",
       "   SUB586  SUB587  SUB588  SUB589  SUB590  SUB591  SUB592  SUB593  SUB594  \\\n",
       "0       0       0       0       0       0       0       0       1       0   \n",
       "1       0       0       0       0       0       0       0       1       0   \n",
       "2       0       0       0       0       0       0       0       1       0   \n",
       "3       1       0       0       0       0       0       0       1       1   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB595  SUB596  SUB597  SUB598  SUB599  SUB600  SUB601  SUB602  SUB603  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       1       0       1       0       1       1       0       1   \n",
       "4       0       0       0       0       0       1       0       0       0   \n",
       "\n",
       "   SUB604  SUB605  SUB606  SUB607  SUB608  SUB609  SUB610  SUB611  SUB612  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       1       0       0       0       1       1       0       0       1   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB613  SUB614  SUB615  SUB616  SUB617  SUB618  SUB619  SUB620  SUB621  \\\n",
       "0       0       1       0       0       0       1       0       0       0   \n",
       "1       0       0       0       0       0       1       0       0       0   \n",
       "2       0       0       0       0       0       1       0       0       0   \n",
       "3       0       1       0       0       0       1       1       0       0   \n",
       "4       0       0       0       0       0       1       0       1       0   \n",
       "\n",
       "   SUB622  SUB623  SUB624  SUB625  SUB626  SUB627  SUB628  SUB629  SUB630  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       0       0       1       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB631  SUB632  SUB633  SUB634  SUB635  SUB636  SUB637  SUB638  SUB639  \\\n",
       "0       0       0       0       0       0       0       0       1       0   \n",
       "1       0       0       0       0       0       0       0       1       0   \n",
       "2       0       0       0       0       0       0       0       1       0   \n",
       "3       0       0       0       1       1       0       1       1       0   \n",
       "4       0       0       0       0       0       0       0       1       0   \n",
       "\n",
       "   SUB640  SUB641  SUB642  SUB643  SUB644  SUB645  SUB646  SUB647  SUB648  \\\n",
       "0       1       0       0       1       0       0       0       0       0   \n",
       "1       0       0       0       0       1       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       1       0       0       1       0       1       1       0   \n",
       "4       0       1       1       1       0       0       0       0       0   \n",
       "\n",
       "   SUB649  SUB650  SUB651  SUB652  SUB653  SUB654  SUB655  SUB656  SUB657  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       1       0       1   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB658  SUB659  SUB660  SUB661  SUB662  SUB663  SUB664  SUB665  SUB666  \\\n",
       "0       0       0       1       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       1       0       1       1       0       0       0       1       1   \n",
       "4       0       0       0       1       0       0       0       0       0   \n",
       "\n",
       "   SUB667  SUB668  SUB669  SUB670  SUB671  SUB672  SUB673  SUB674  SUB675  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       1       1       1       0   \n",
       "4       0       1       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB676  SUB677  SUB678  SUB679  SUB680  SUB681  SUB682  SUB683  SUB684  \\\n",
       "0       0       0       0       0       0       0       0       1       0   \n",
       "1       0       0       0       0       0       0       0       1       0   \n",
       "2       0       0       0       0       0       1       0       0       1   \n",
       "3       0       0       1       1       1       1       0       1       1   \n",
       "4       0       0       0       1       1       1       0       0       0   \n",
       "\n",
       "   SUB685  SUB686  SUB687  SUB688  SUB689  SUB690  SUB691  SUB692  SUB693  \\\n",
       "0       0       1       0       0       0       0       0       0       0   \n",
       "1       0       1       0       0       0       0       0       0       0   \n",
       "2       1       0       1       1       0       0       0       1       0   \n",
       "3       1       1       0       0       1       0       1       0       1   \n",
       "4       1       0       1       0       1       1       0       0       1   \n",
       "\n",
       "   SUB694  SUB695  SUB696  SUB697  SUB698  SUB699  SUB700  SUB701  SUB702  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       1       0       0       0       0       0       0   \n",
       "3       1       1       1       0       0       0       0       0       0   \n",
       "4       0       0       0       1       0       0       0       0       0   \n",
       "\n",
       "   SUB703  SUB704  SUB705  SUB706  SUB707  SUB708  SUB709  SUB710  SUB711  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       1       0       0       1       1       1       1   \n",
       "4       0       0       1       0       0       0       1       1       1   \n",
       "\n",
       "   SUB712  SUB713  SUB714  SUB715  SUB716  SUB717  SUB718  SUB719  SUB720  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       1       0       0       0   \n",
       "4       0       1       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB721  SUB722  SUB723  SUB724  SUB725  SUB726  SUB727  SUB728  SUB729  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB730  SUB731  SUB732  SUB733  SUB734  SUB735  SUB736  SUB737  SUB738  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB739  SUB740  SUB741  SUB742  SUB743  SUB744  SUB745  SUB746  SUB747  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB748  SUB749  SUB750  SUB751  SUB752  SUB753  SUB754  SUB755  SUB756  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB757  SUB758  SUB759  SUB760  SUB761  SUB762  SUB763  SUB764  SUB765  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB766  SUB767  SUB768  SUB769  SUB770  SUB771  SUB772  SUB773  SUB774  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB775  SUB776  SUB777  SUB778  SUB779  SUB780  SUB781  SUB782  SUB783  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       1       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB784  SUB785  SUB786  SUB787  SUB788  SUB789  SUB790  SUB791  SUB792  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB793  SUB794  SUB795  SUB796  SUB797  SUB798  SUB799  SUB800  SUB801  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB802  SUB803  SUB804  SUB805  SUB806  SUB807  SUB808  SUB809  SUB810  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB811  SUB812  SUB813  SUB814  SUB815  SUB816  SUB817  SUB818  SUB819  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB820  SUB821  SUB822  SUB823  SUB824  SUB825  SUB826  SUB827  SUB828  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB829  SUB830  SUB831  SUB832  SUB833  SUB834  SUB835  SUB836  SUB837  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB838  SUB839  SUB840  SUB841  SUB842  SUB843  SUB844  SUB845  SUB846  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       1       0       0       0       0       0   \n",
       "\n",
       "   SUB847  SUB848  SUB849  SUB850  SUB851  SUB852  SUB853  SUB854  SUB855  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB856  SUB857  SUB858  SUB859  SUB860  SUB861  SUB862  SUB863  SUB864  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       1       1       0       0   \n",
       "\n",
       "   SUB865  SUB866  SUB867  SUB868  SUB869  SUB870  SUB871  SUB872  SUB873  \\\n",
       "0       0       0       0       0       0       0       0       0       0   \n",
       "1       0       0       0       0       0       0       0       0       0   \n",
       "2       0       0       0       0       0       0       0       0       0   \n",
       "3       0       0       0       0       0       0       0       0       0   \n",
       "4       0       0       0       0       0       0       0       0       0   \n",
       "\n",
       "   SUB874  SUB875  SUB876  SUB877  SUB878  SUB879  SUB880  SUB881  \n",
       "0       0       0       0       0       0       0       0       0  \n",
       "1       0       0       0       0       0       0       0       0  \n",
       "2       0       0       0       0       0       0       0       0  \n",
       "3       0       0       0       0       0       0       0       0  \n",
       "4       0       0       0       0       0       0       0       0  "
      ]
     },
     "execution_count": 30,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#Import chemical substr dataset\n",
    "chem_str=pd.read_csv('data/chemical_substr.txt', sep='\\t')\n",
    "chem_str.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Load all the Pauwel's dataset\n",
    "#http://members.cbio.mines-paristech.fr/~yyamanishi/side-effect/"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Load Liu dataset from .mat file in NSS/capstone/data folder"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Load Mituzani datasets\n",
    "#http://web.kuicr.kyoto-u.ac.jp/supp/smizutan/target-effect/"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/opt/anaconda3/lib/python3.7/site-packages/IPython/core/interactiveshell.py:3058: DtypeWarning: Columns (0,2,4,5,6,7,8,9,10) have mixed types. Specify dtype option on import or set low_memory=False.\n",
      "  interactivity=interactivity, compiler=compiler, result=result)\n"
     ]
    }
   ],
   "source": [
    "#Import off_sides dataset. OFFSIDES- associations before drug approval\n",
    "off_sides=pd.read_csv('data/OFFSIDES.csv.xz.csv', compression='xz', header=0, sep=',', quotechar='\"')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
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       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>drug_rxnorn_id</th>\n",
       "      <th>drug_concept_name</th>\n",
       "      <th>condition_meddra_id</th>\n",
       "      <th>condition_concept_name</th>\n",
       "      <th>A</th>\n",
       "      <th>B</th>\n",
       "      <th>C</th>\n",
       "      <th>D</th>\n",
       "      <th>PRR</th>\n",
       "      <th>PRR_error</th>\n",
       "      <th>mean_reporting_frequency</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>4024</td>\n",
       "      <td>ergoloid mesylates, USP</td>\n",
       "      <td>10002034</td>\n",
       "      <td>Anaemia</td>\n",
       "      <td>6</td>\n",
       "      <td>126</td>\n",
       "      <td>21</td>\n",
       "      <td>1299</td>\n",
       "      <td>2.85714</td>\n",
       "      <td>0.45382</td>\n",
       "      <td>0.0454545</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>4024</td>\n",
       "      <td>ergoloid mesylates, USP</td>\n",
       "      <td>10002965</td>\n",
       "      <td>Aplasia pure red cell</td>\n",
       "      <td>1</td>\n",
       "      <td>131</td>\n",
       "      <td>1</td>\n",
       "      <td>1319</td>\n",
       "      <td>10</td>\n",
       "      <td>1.41126</td>\n",
       "      <td>0.00757576</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>2</td>\n",
       "      <td>4024</td>\n",
       "      <td>ergoloid mesylates, USP</td>\n",
       "      <td>10013442</td>\n",
       "      <td>Disseminated intravascular coagulation</td>\n",
       "      <td>1</td>\n",
       "      <td>131</td>\n",
       "      <td>6</td>\n",
       "      <td>1314</td>\n",
       "      <td>1.66667</td>\n",
       "      <td>1.07626</td>\n",
       "      <td>0.00757576</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>3</td>\n",
       "      <td>4024</td>\n",
       "      <td>ergoloid mesylates, USP</td>\n",
       "      <td>10023126</td>\n",
       "      <td>Jaundice</td>\n",
       "      <td>2</td>\n",
       "      <td>130</td>\n",
       "      <td>7</td>\n",
       "      <td>1313</td>\n",
       "      <td>2.85714</td>\n",
       "      <td>0.79657</td>\n",
       "      <td>0.0151515</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>4</td>\n",
       "      <td>4024</td>\n",
       "      <td>ergoloid mesylates, USP</td>\n",
       "      <td>10016288</td>\n",
       "      <td>Febrile neutropenia</td>\n",
       "      <td>1</td>\n",
       "      <td>131</td>\n",
       "      <td>5</td>\n",
       "      <td>1315</td>\n",
       "      <td>2</td>\n",
       "      <td>1.09163</td>\n",
       "      <td>0.00757576</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  drug_rxnorn_id        drug_concept_name condition_meddra_id  \\\n",
       "0           4024  ergoloid mesylates, USP            10002034   \n",
       "1           4024  ergoloid mesylates, USP            10002965   \n",
       "2           4024  ergoloid mesylates, USP            10013442   \n",
       "3           4024  ergoloid mesylates, USP            10023126   \n",
       "4           4024  ergoloid mesylates, USP            10016288   \n",
       "\n",
       "                   condition_concept_name  A    B   C     D      PRR  \\\n",
       "0                                 Anaemia  6  126  21  1299  2.85714   \n",
       "1                   Aplasia pure red cell  1  131   1  1319       10   \n",
       "2  Disseminated intravascular coagulation  1  131   6  1314  1.66667   \n",
       "3                                Jaundice  2  130   7  1313  2.85714   \n",
       "4                     Febrile neutropenia  1  131   5  1315        2   \n",
       "\n",
       "  PRR_error mean_reporting_frequency  \n",
       "0   0.45382                0.0454545  \n",
       "1   1.41126               0.00757576  \n",
       "2   1.07626               0.00757576  \n",
       "3   0.79657                0.0151515  \n",
       "4   1.09163               0.00757576  "
      ]
     },
     "execution_count": 20,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "off_sides.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/opt/anaconda3/lib/python3.7/site-packages/IPython/core/interactiveshell.py:3058: DtypeWarning: Columns (0,2,4,6,7,8,9,10,11,12) have mixed types. Specify dtype option on import or set low_memory=False.\n",
      "  interactivity=interactivity, compiler=compiler, result=result)\n"
     ]
    }
   ],
   "source": [
    "#Import two sides dataset. TWOSIDES - data of side effects of pairs of drugs\n",
    "two_sides=pd.read_csv('data/TWOSIDES.csv.xz.csv', compression='xz', header=0, sep=',', quotechar='\"')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>drug_1_rxnorn_id</th>\n",
       "      <th>drug_1_concept_name</th>\n",
       "      <th>drug_2_rxnorm_id</th>\n",
       "      <th>drug_2_concept_name</th>\n",
       "      <th>condition_meddra_id</th>\n",
       "      <th>condition_concept_name</th>\n",
       "      <th>A</th>\n",
       "      <th>B</th>\n",
       "      <th>C</th>\n",
       "      <th>D</th>\n",
       "      <th>PRR</th>\n",
       "      <th>PRR_error</th>\n",
       "      <th>mean_reporting_frequency</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>10355</td>\n",
       "      <td>Temazepam</td>\n",
       "      <td>136411</td>\n",
       "      <td>sildenafil</td>\n",
       "      <td>10003239</td>\n",
       "      <td>Arthralgia</td>\n",
       "      <td>7</td>\n",
       "      <td>149</td>\n",
       "      <td>24</td>\n",
       "      <td>1536</td>\n",
       "      <td>2.91667</td>\n",
       "      <td>0.421275</td>\n",
       "      <td>0.0448718</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>1808</td>\n",
       "      <td>Bumetanide</td>\n",
       "      <td>7824</td>\n",
       "      <td>Oxytocin</td>\n",
       "      <td>10003239</td>\n",
       "      <td>Arthralgia</td>\n",
       "      <td>1</td>\n",
       "      <td>13</td>\n",
       "      <td>2</td>\n",
       "      <td>138</td>\n",
       "      <td>5.0</td>\n",
       "      <td>1.19224</td>\n",
       "      <td>0.0714286</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  drug_1_rxnorn_id drug_1_concept_name drug_2_rxnorm_id drug_2_concept_name  \\\n",
       "0            10355           Temazepam           136411          sildenafil   \n",
       "1             1808          Bumetanide             7824            Oxytocin   \n",
       "\n",
       "  condition_meddra_id condition_concept_name  A    B   C     D      PRR  \\\n",
       "0            10003239             Arthralgia  7  149  24  1536  2.91667   \n",
       "1            10003239             Arthralgia  1   13   2   138      5.0   \n",
       "\n",
       "  PRR_error mean_reporting_frequency  \n",
       "0  0.421275                0.0448718  \n",
       "1   1.19224                0.0714286  "
      ]
     },
     "execution_count": 22,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "two_sides.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "1716"
      ]
     },
     "execution_count": 23,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "two_sides.drug_1_concept_name.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#pivot two-sides\n",
    "#res = df.pivot_table(index=['item', 'day'], columns='time',\n",
    "#                    values='data', aggfunc='first').reset_index()\n",
    "\n",
    "two_sides_pivot=two_sides.drop(['A', 'B', 'C', 'D', 'PRR', 'PRR_error', 'mean_reporting_frequency'], axis=1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "two_sides_pivot.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "two_sides_pivot=two_sides_pivot.pivot_table(index=['drug_1_rxnorn_id', 'drug_1_concept_name', 'drug_2_rxnorm_id'\\\n",
    "                                                  'drug_2_concept_name'], columns='')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "how many drug-drug interactions"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "q to michael:  two_sides have side effect for the 2 drugs already. how are we going to merge the chemical substru"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "metadata": {},
   "outputs": [],
   "source": [
    "side_effect_binary=pd.read_csv('data/source_codes_and_datasets_2015-09-05/Liu_dataset_and_experiments/Liu_dataset/merged_data/random_group_cv_data.indication', sep = '\\t', delimiter = '|', engine= 'python', header = None)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "metadata": {},
   "outputs": [],
   "source": [
    "side_effect_binary.columns=['drugBankID', 'drugName', 'compoundID', 'ADE_str', 'chem_str', \\\n",
    "                           'target_gene', 'transporter', 'enzyme', 'kgg', 'indication', \\\n",
    "                           'group_str']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "<class 'pandas.core.frame.DataFrame'>\n",
      "RangeIndex: 832 entries, 0 to 831\n",
      "Data columns (total 11 columns):\n",
      "drugBankID     832 non-null object\n",
      "drugName       832 non-null object\n",
      "compoundID     832 non-null int64\n",
      "ADE_str        832 non-null object\n",
      "chem_str       832 non-null object\n",
      "target_gene    832 non-null object\n",
      "transporter    832 non-null object\n",
      "enzyme         832 non-null object\n",
      "kgg            832 non-null object\n",
      "indication     832 non-null object\n",
      "group_str      832 non-null object\n",
      "dtypes: int64(1), object(10)\n",
      "memory usage: 71.6+ KB\n"
     ]
    }
   ],
   "source": [
    "side_effect_binary.info()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>drugBankID</th>\n",
       "      <th>drugName</th>\n",
       "      <th>compoundID</th>\n",
       "      <th>ADE_str</th>\n",
       "      <th>chem_str</th>\n",
       "      <th>target_gene</th>\n",
       "      <th>transporter</th>\n",
       "      <th>enzyme</th>\n",
       "      <th>kgg</th>\n",
       "      <th>indication</th>\n",
       "      <th>group_str</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>DB00220</td>\n",
       "      <td>nelfinavir</td>\n",
       "      <td>4451</td>\n",
       "      <td>0010000000000000000000000000000000001000000000...</td>\n",
       "      <td>0000111111111110000111000000000000000010000000...</td>\n",
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       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>DB01340</td>\n",
       "      <td>cilazapril</td>\n",
       "      <td>2751</td>\n",
       "      <td>0010000000000000000100000001000000001010000000...</td>\n",
       "      <td>0000011111011110000111000000000000000000000000...</td>\n",
       "      <td>0000000000000000000000000000000000000000000000...</td>\n",
       "      <td>0000000000000000000000000000000000000000000000...</td>\n",
       "      <td>0000000000000000000000000000000000000000000000...</td>\n",
       "      <td>0000000000000000000000000000000000000000010000...</td>\n",
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       "      <td>4,2,3,4,4,2,1,4,0,4,4,4,2,2,3,0,2,0,0,3,3,1,3,...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  drugBankID    drugName  compoundID  \\\n",
       "0    DB00220  nelfinavir        4451   \n",
       "1    DB01340  cilazapril        2751   \n",
       "\n",
       "                                             ADE_str  \\\n",
       "0  0010000000000000000000000000000000001000000000...   \n",
       "1  0010000000000000000100000001000000001010000000...   \n",
       "\n",
       "                                            chem_str  \\\n",
       "0  0000111111111110000111000000000000000010000000...   \n",
       "1  0000011111011110000111000000000000000000000000...   \n",
       "\n",
       "                                         target_gene  \\\n",
       "0  0000000000000000000000000000000000000000000000...   \n",
       "1  0000000000000000000000000000000000000000000000...   \n",
       "\n",
       "                                         transporter  \\\n",
       "0  0000000000000000100001000000000000000000000000...   \n",
       "1  0000000000000000000000000000000000000000000000...   \n",
       "\n",
       "                                              enzyme  \\\n",
       "0  0000000000000000000000000000000000000000010000...   \n",
       "1  0000000000000000000000000000000000000000000000...   \n",
       "\n",
       "                                                 kgg  \\\n",
       "0  0000000000000000000000000000000000000000000000...   \n",
       "1  0000000000000000000000000000000000000000010000...   \n",
       "\n",
       "                                          indication  \\\n",
       "0  0000000000000000000000000000000100000000000000...   \n",
       "1  0000000000000000000000000000000000000000000000...   \n",
       "\n",
       "                                           group_str  \n",
       "0  3,0,0,2,4,2,3,4,0,3,2,0,4,2,3,3,3,0,2,3,4,4,4,...  \n",
       "1  4,2,3,4,4,2,1,4,0,4,4,4,2,2,3,0,2,0,0,3,3,1,3,...  "
      ]
     },
     "execution_count": 35,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "side_effect_binary.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
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       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>drugBankID</th>\n",
       "      <th>drugName</th>\n",
       "      <th>compoundID</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>DB00220</td>\n",
       "      <td>nelfinavir</td>\n",
       "      <td>4451</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <td>1</td>\n",
       "      <td>DB01340</td>\n",
       "      <td>cilazapril</td>\n",
       "      <td>2751</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  drugBankID    drugName  compoundID\n",
       "0    DB00220  nelfinavir        4451\n",
       "1    DB01340  cilazapril        2751"
      ]
     },
     "execution_count": 36,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "side_effect_binary1=side_effect_binary[['drugBankID', 'drugName', 'compoundID']]\n",
    "side_effect_binary1.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "metadata": {},
   "outputs": [],
   "source": [
    "side_effect_binary_str=side_effect_binary[['ADE_str', 'chem_str', 'target_gene', \\\n",
    "                                           'transporter', 'enzyme', 'kgg', 'indication'\n",
    "                                          ]]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "pandas.core.frame.DataFrame"
      ]
     },
     "execution_count": 38,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "type(side_effect_binary_str)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 41,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "pandas.core.series.Series"
      ]
     },
     "execution_count": 41,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "#convert ADE_str to list and then to dataframe and concatenate to side_effect_binary1\n",
    "side_effect_binary_ade=side_effect_binary_str.ADE_str.apply(list)\n",
    "type(side_effect_binary_ade)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 42,
   "metadata": {},
   "outputs": [],
   "source": [
    "se_binary_ade=pd.DataFrame(side_effect_binary_ade.tolist())"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 43,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "pandas.core.frame.DataFrame"
      ]
     },
     "execution_count": 43,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "type(se_binary_ade)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 44,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
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       "\n",
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>drugBankID</th>\n",
       "      <th>drugName</th>\n",
       "      <th>compoundID</th>\n",
       "      <th>0</th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
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       "      <th>34</th>\n",
       "      <th>35</th>\n",
       "      <th>36</th>\n",
       "      <th>37</th>\n",
       "      <th>38</th>\n",
       "      <th>39</th>\n",
       "      <th>40</th>\n",
       "      <th>41</th>\n",
       "      <th>42</th>\n",
       "      <th>43</th>\n",
       "      <th>44</th>\n",
       "      <th>45</th>\n",
       "      <th>46</th>\n",
       "      <th>47</th>\n",
       "      <th>48</th>\n",
       "      <th>49</th>\n",
       "      <th>50</th>\n",
       "      <th>51</th>\n",
       "      <th>52</th>\n",
       "      <th>53</th>\n",
       "      <th>54</th>\n",
       "      <th>55</th>\n",
       "      <th>56</th>\n",
       "      <th>57</th>\n",
       "      <th>58</th>\n",
       "      <th>59</th>\n",
       "      <th>60</th>\n",
       "      <th>61</th>\n",
       "      <th>62</th>\n",
       "      <th>63</th>\n",
       "      <th>64</th>\n",
       "      <th>65</th>\n",
       "      <th>66</th>\n",
       "      <th>67</th>\n",
       "      <th>68</th>\n",
       "      <th>69</th>\n",
       "      <th>70</th>\n",
       "      <th>71</th>\n",
       "      <th>72</th>\n",
       "      <th>73</th>\n",
       "      <th>74</th>\n",
       "      <th>75</th>\n",
       "      <th>76</th>\n",
       "      <th>77</th>\n",
       "      <th>78</th>\n",
       "      <th>79</th>\n",
       "      <th>80</th>\n",
       "      <th>81</th>\n",
       "      <th>82</th>\n",
       "      <th>83</th>\n",
       "      <th>84</th>\n",
       "      <th>85</th>\n",
       "      <th>86</th>\n",
       "      <th>87</th>\n",
       "      <th>88</th>\n",
       "      <th>89</th>\n",
       "      <th>90</th>\n",
       "      <th>91</th>\n",
       "      <th>92</th>\n",
       "      <th>93</th>\n",
       "      <th>94</th>\n",
       "      <th>95</th>\n",
       "      <th>96</th>\n",
       "      <th>97</th>\n",
       "      <th>98</th>\n",
       "      <th>99</th>\n",
       "      <th>100</th>\n",
       "      <th>101</th>\n",
       "      <th>102</th>\n",
       "      <th>103</th>\n",
       "      <th>104</th>\n",
       "      <th>105</th>\n",
       "      <th>106</th>\n",
       "      <th>107</th>\n",
       "      <th>108</th>\n",
       "      <th>109</th>\n",
       "      <th>110</th>\n",
       "      <th>111</th>\n",
       "      <th>112</th>\n",
       "      <th>113</th>\n",
       "      <th>114</th>\n",
       "      <th>115</th>\n",
       "      <th>116</th>\n",
       "      <th>117</th>\n",
       "      <th>118</th>\n",
       "      <th>119</th>\n",
       "      <th>120</th>\n",
       "      <th>121</th>\n",
       "      <th>122</th>\n",
       "      <th>123</th>\n",
       "      <th>124</th>\n",
       "      <th>125</th>\n",
       "      <th>126</th>\n",
       "      <th>127</th>\n",
       "      <th>128</th>\n",
       "      <th>129</th>\n",
       "      <th>130</th>\n",
       "      <th>131</th>\n",
       "      <th>132</th>\n",
       "      <th>133</th>\n",
       "      <th>134</th>\n",
       "      <th>135</th>\n",
       "      <th>136</th>\n",
       "      <th>137</th>\n",
       "      <th>138</th>\n",
       "      <th>139</th>\n",
       "      <th>140</th>\n",
       "      <th>141</th>\n",
       "      <th>142</th>\n",
       "      <th>143</th>\n",
       "      <th>144</th>\n",
       "      <th>145</th>\n",
       "      <th>146</th>\n",
       "      <th>147</th>\n",
       "      <th>148</th>\n",
       "      <th>149</th>\n",
       "      <th>150</th>\n",
       "      <th>151</th>\n",
       "      <th>152</th>\n",
       "      <th>153</th>\n",
       "      <th>154</th>\n",
       "      <th>155</th>\n",
       "      <th>156</th>\n",
       "      <th>157</th>\n",
       "      <th>158</th>\n",
       "      <th>159</th>\n",
       "      <th>160</th>\n",
       "      <th>161</th>\n",
       "      <th>162</th>\n",
       "      <th>163</th>\n",
       "      <th>164</th>\n",
       "      <th>165</th>\n",
       "      <th>166</th>\n",
       "      <th>167</th>\n",
       "      <th>168</th>\n",
       "      <th>169</th>\n",
       "      <th>170</th>\n",
       "      <th>171</th>\n",
       "      <th>172</th>\n",
       "      <th>173</th>\n",
       "      <th>174</th>\n",
       "      <th>175</th>\n",
       "      <th>176</th>\n",
       "      <th>177</th>\n",
       "      <th>178</th>\n",
       "      <th>179</th>\n",
       "      <th>180</th>\n",
       "      <th>181</th>\n",
       "      <th>182</th>\n",
       "      <th>183</th>\n",
       "      <th>184</th>\n",
       "      <th>185</th>\n",
       "      <th>186</th>\n",
       "      <th>187</th>\n",
       "      <th>188</th>\n",
       "      <th>189</th>\n",
       "      <th>190</th>\n",
       "      <th>191</th>\n",
       "      <th>192</th>\n",
       "      <th>193</th>\n",
       "      <th>194</th>\n",
       "      <th>195</th>\n",
       "      <th>196</th>\n",
       "      <th>197</th>\n",
       "      <th>198</th>\n",
       "      <th>199</th>\n",
       "      <th>200</th>\n",
       "      <th>201</th>\n",
       "      <th>202</th>\n",
       "      <th>203</th>\n",
       "      <th>204</th>\n",
       "      <th>205</th>\n",
       "      <th>206</th>\n",
       "      <th>207</th>\n",
       "      <th>208</th>\n",
       "      <th>209</th>\n",
       "      <th>210</th>\n",
       "      <th>211</th>\n",
       "      <th>212</th>\n",
       "      <th>213</th>\n",
       "      <th>214</th>\n",
       "      <th>215</th>\n",
       "      <th>216</th>\n",
       "      <th>217</th>\n",
       "      <th>218</th>\n",
       "      <th>219</th>\n",
       "      <th>220</th>\n",
       "      <th>221</th>\n",
       "      <th>222</th>\n",
       "      <th>223</th>\n",
       "      <th>224</th>\n",
       "      <th>225</th>\n",
       "      <th>226</th>\n",
       "      <th>227</th>\n",
       "      <th>228</th>\n",
       "      <th>229</th>\n",
       "      <th>230</th>\n",
       "      <th>231</th>\n",
       "      <th>232</th>\n",
       "      <th>233</th>\n",
       "      <th>234</th>\n",
       "      <th>235</th>\n",
       "      <th>236</th>\n",
       "      <th>237</th>\n",
       "      <th>238</th>\n",
       "      <th>239</th>\n",
       "      <th>240</th>\n",
       "      <th>241</th>\n",
       "      <th>242</th>\n",
       "      <th>243</th>\n",
       "      <th>244</th>\n",
       "      <th>245</th>\n",
       "      <th>246</th>\n",
       "      <th>247</th>\n",
       "      <th>248</th>\n",
       "      <th>249</th>\n",
       "      <th>250</th>\n",
       "      <th>251</th>\n",
       "      <th>252</th>\n",
       "      <th>253</th>\n",
       "      <th>254</th>\n",
       "      <th>255</th>\n",
       "      <th>256</th>\n",
       "      <th>257</th>\n",
       "      <th>258</th>\n",
       "      <th>259</th>\n",
       "      <th>260</th>\n",
       "      <th>261</th>\n",
       "      <th>262</th>\n",
       "      <th>263</th>\n",
       "      <th>264</th>\n",
       "      <th>265</th>\n",
       "      <th>266</th>\n",
       "      <th>267</th>\n",
       "      <th>268</th>\n",
       "      <th>269</th>\n",
       "      <th>270</th>\n",
       "      <th>271</th>\n",
       "      <th>272</th>\n",
       "      <th>273</th>\n",
       "      <th>274</th>\n",
       "      <th>275</th>\n",
       "      <th>276</th>\n",
       "      <th>277</th>\n",
       "      <th>278</th>\n",
       "      <th>279</th>\n",
       "      <th>280</th>\n",
       "      <th>281</th>\n",
       "      <th>282</th>\n",
       "      <th>283</th>\n",
       "      <th>284</th>\n",
       "      <th>285</th>\n",
       "      <th>286</th>\n",
       "      <th>287</th>\n",
       "      <th>288</th>\n",
       "      <th>289</th>\n",
       "      <th>290</th>\n",
       "      <th>291</th>\n",
       "      <th>292</th>\n",
       "      <th>293</th>\n",
       "      <th>294</th>\n",
       "      <th>295</th>\n",
       "      <th>296</th>\n",
       "      <th>297</th>\n",
       "      <th>298</th>\n",
       "      <th>299</th>\n",
       "      <th>300</th>\n",
       "      <th>301</th>\n",
       "      <th>302</th>\n",
       "      <th>303</th>\n",
       "      <th>304</th>\n",
       "      <th>305</th>\n",
       "      <th>306</th>\n",
       "      <th>307</th>\n",
       "      <th>308</th>\n",
       "      <th>309</th>\n",
       "      <th>310</th>\n",
       "      <th>311</th>\n",
       "      <th>312</th>\n",
       "      <th>313</th>\n",
       "      <th>314</th>\n",
       "      <th>315</th>\n",
       "      <th>316</th>\n",
       "      <th>317</th>\n",
       "      <th>318</th>\n",
       "      <th>319</th>\n",
       "      <th>320</th>\n",
       "      <th>321</th>\n",
       "      <th>322</th>\n",
       "      <th>323</th>\n",
       "      <th>324</th>\n",
       "      <th>325</th>\n",
       "      <th>326</th>\n",
       "      <th>327</th>\n",
       "      <th>328</th>\n",
       "      <th>329</th>\n",
       "      <th>330</th>\n",
       "      <th>331</th>\n",
       "      <th>332</th>\n",
       "      <th>333</th>\n",
       "      <th>334</th>\n",
       "      <th>335</th>\n",
       "      <th>336</th>\n",
       "      <th>337</th>\n",
       "      <th>338</th>\n",
       "      <th>339</th>\n",
       "      <th>340</th>\n",
       "      <th>341</th>\n",
       "      <th>342</th>\n",
       "      <th>343</th>\n",
       "      <th>344</th>\n",
       "      <th>345</th>\n",
       "      <th>346</th>\n",
       "      <th>347</th>\n",
       "      <th>348</th>\n",
       "      <th>349</th>\n",
       "      <th>350</th>\n",
       "      <th>351</th>\n",
       "      <th>352</th>\n",
       "      <th>353</th>\n",
       "      <th>354</th>\n",
       "      <th>355</th>\n",
       "      <th>356</th>\n",
       "      <th>357</th>\n",
       "      <th>358</th>\n",
       "      <th>359</th>\n",
       "      <th>360</th>\n",
       "      <th>361</th>\n",
       "      <th>362</th>\n",
       "      <th>363</th>\n",
       "      <th>364</th>\n",
       "      <th>365</th>\n",
       "      <th>366</th>\n",
       "      <th>367</th>\n",
       "      <th>368</th>\n",
       "      <th>369</th>\n",
       "      <th>370</th>\n",
       "      <th>371</th>\n",
       "      <th>372</th>\n",
       "      <th>373</th>\n",
       "      <th>374</th>\n",
       "      <th>375</th>\n",
       "      <th>376</th>\n",
       "      <th>377</th>\n",
       "      <th>378</th>\n",
       "      <th>379</th>\n",
       "      <th>380</th>\n",
       "      <th>381</th>\n",
       "      <th>382</th>\n",
       "      <th>383</th>\n",
       "      <th>384</th>\n",
       "      <th>385</th>\n",
       "      <th>386</th>\n",
       "      <th>387</th>\n",
       "      <th>388</th>\n",
       "      <th>389</th>\n",
       "      <th>390</th>\n",
       "      <th>391</th>\n",
       "      <th>392</th>\n",
       "      <th>393</th>\n",
       "      <th>394</th>\n",
       "      <th>395</th>\n",
       "      <th>396</th>\n",
       "      <th>397</th>\n",
       "      <th>398</th>\n",
       "      <th>399</th>\n",
       "      <th>400</th>\n",
       "      <th>401</th>\n",
       "      <th>402</th>\n",
       "      <th>403</th>\n",
       "      <th>404</th>\n",
       "      <th>405</th>\n",
       "      <th>406</th>\n",
       "      <th>407</th>\n",
       "      <th>408</th>\n",
       "      <th>409</th>\n",
       "      <th>410</th>\n",
       "      <th>411</th>\n",
       "      <th>412</th>\n",
       "      <th>413</th>\n",
       "      <th>414</th>\n",
       "      <th>415</th>\n",
       "      <th>416</th>\n",
       "      <th>417</th>\n",
       "      <th>418</th>\n",
       "      <th>419</th>\n",
       "      <th>420</th>\n",
       "      <th>421</th>\n",
       "      <th>422</th>\n",
       "      <th>423</th>\n",
       "      <th>424</th>\n",
       "      <th>425</th>\n",
       "      <th>426</th>\n",
       "      <th>427</th>\n",
       "      <th>428</th>\n",
       "      <th>429</th>\n",
       "      <th>430</th>\n",
       "      <th>431</th>\n",
       "      <th>432</th>\n",
       "      <th>433</th>\n",
       "      <th>434</th>\n",
       "      <th>435</th>\n",
       "      <th>436</th>\n",
       "      <th>437</th>\n",
       "      <th>438</th>\n",
       "      <th>439</th>\n",
       "      <th>440</th>\n",
       "      <th>441</th>\n",
       "      <th>442</th>\n",
       "      <th>443</th>\n",
       "      <th>444</th>\n",
       "      <th>445</th>\n",
       "      <th>446</th>\n",
       "      <th>447</th>\n",
       "      <th>448</th>\n",
       "      <th>449</th>\n",
       "      <th>450</th>\n",
       "      <th>451</th>\n",
       "      <th>452</th>\n",
       "      <th>453</th>\n",
       "      <th>454</th>\n",
       "      <th>455</th>\n",
       "      <th>456</th>\n",
       "      <th>457</th>\n",
       "      <th>458</th>\n",
       "      <th>459</th>\n",
       "      <th>460</th>\n",
       "      <th>461</th>\n",
       "      <th>462</th>\n",
       "      <th>463</th>\n",
       "      <th>464</th>\n",
       "      <th>465</th>\n",
       "      <th>466</th>\n",
       "      <th>467</th>\n",
       "      <th>468</th>\n",
       "      <th>469</th>\n",
       "      <th>470</th>\n",
       "      <th>471</th>\n",
       "      <th>472</th>\n",
       "      <th>473</th>\n",
       "      <th>474</th>\n",
       "      <th>475</th>\n",
       "      <th>476</th>\n",
       "      <th>477</th>\n",
       "      <th>478</th>\n",
       "      <th>479</th>\n",
       "      <th>480</th>\n",
       "      <th>481</th>\n",
       "      <th>482</th>\n",
       "      <th>483</th>\n",
       "      <th>484</th>\n",
       "      <th>485</th>\n",
       "      <th>486</th>\n",
       "      <th>487</th>\n",
       "      <th>488</th>\n",
       "      <th>489</th>\n",
       "      <th>490</th>\n",
       "      <th>491</th>\n",
       "      <th>492</th>\n",
       "      <th>493</th>\n",
       "      <th>494</th>\n",
       "      <th>495</th>\n",
       "      <th>496</th>\n",
       "      <th>497</th>\n",
       "      <th>498</th>\n",
       "      <th>499</th>\n",
       "      <th>500</th>\n",
       "      <th>501</th>\n",
       "      <th>502</th>\n",
       "      <th>503</th>\n",
       "      <th>504</th>\n",
       "      <th>505</th>\n",
       "      <th>506</th>\n",
       "      <th>507</th>\n",
       "      <th>508</th>\n",
       "      <th>509</th>\n",
       "      <th>510</th>\n",
       "      <th>511</th>\n",
       "      <th>512</th>\n",
       "      <th>513</th>\n",
       "      <th>514</th>\n",
       "      <th>515</th>\n",
       "      <th>516</th>\n",
       "      <th>517</th>\n",
       "      <th>518</th>\n",
       "      <th>519</th>\n",
       "      <th>520</th>\n",
       "      <th>521</th>\n",
       "      <th>522</th>\n",
       "      <th>523</th>\n",
       "      <th>524</th>\n",
       "      <th>525</th>\n",
       "      <th>526</th>\n",
       "      <th>527</th>\n",
       "      <th>528</th>\n",
       "      <th>529</th>\n",
       "      <th>530</th>\n",
       "      <th>531</th>\n",
       "      <th>532</th>\n",
       "      <th>533</th>\n",
       "      <th>534</th>\n",
       "      <th>535</th>\n",
       "      <th>536</th>\n",
       "      <th>537</th>\n",
       "      <th>538</th>\n",
       "      <th>539</th>\n",
       "      <th>540</th>\n",
       "      <th>541</th>\n",
       "      <th>542</th>\n",
       "      <th>543</th>\n",
       "      <th>544</th>\n",
       "      <th>545</th>\n",
       "      <th>546</th>\n",
       "      <th>547</th>\n",
       "      <th>548</th>\n",
       "      <th>549</th>\n",
       "      <th>550</th>\n",
       "      <th>551</th>\n",
       "      <th>552</th>\n",
       "      <th>553</th>\n",
       "      <th>554</th>\n",
       "      <th>555</th>\n",
       "      <th>556</th>\n",
       "      <th>557</th>\n",
       "      <th>558</th>\n",
       "      <th>559</th>\n",
       "      <th>560</th>\n",
       "      <th>561</th>\n",
       "      <th>562</th>\n",
       "      <th>563</th>\n",
       "      <th>564</th>\n",
       "      <th>565</th>\n",
       "      <th>566</th>\n",
       "      <th>567</th>\n",
       "      <th>568</th>\n",
       "      <th>569</th>\n",
       "      <th>570</th>\n",
       "      <th>571</th>\n",
       "      <th>572</th>\n",
       "      <th>573</th>\n",
       "      <th>574</th>\n",
       "      <th>575</th>\n",
       "      <th>576</th>\n",
       "      <th>577</th>\n",
       "      <th>578</th>\n",
       "      <th>579</th>\n",
       "      <th>580</th>\n",
       "      <th>581</th>\n",
       "      <th>582</th>\n",
       "      <th>583</th>\n",
       "      <th>584</th>\n",
       "      <th>585</th>\n",
       "      <th>586</th>\n",
       "      <th>587</th>\n",
       "      <th>588</th>\n",
       "      <th>589</th>\n",
       "      <th>590</th>\n",
       "      <th>591</th>\n",
       "      <th>592</th>\n",
       "      <th>593</th>\n",
       "      <th>594</th>\n",
       "      <th>595</th>\n",
       "      <th>596</th>\n",
       "      <th>597</th>\n",
       "      <th>598</th>\n",
       "      <th>599</th>\n",
       "      <th>600</th>\n",
       "      <th>601</th>\n",
       "      <th>602</th>\n",
       "      <th>603</th>\n",
       "      <th>604</th>\n",
       "      <th>605</th>\n",
       "      <th>606</th>\n",
       "      <th>607</th>\n",
       "      <th>608</th>\n",
       "      <th>609</th>\n",
       "      <th>610</th>\n",
       "      <th>611</th>\n",
       "      <th>612</th>\n",
       "      <th>613</th>\n",
       "      <th>614</th>\n",
       "      <th>615</th>\n",
       "      <th>616</th>\n",
       "      <th>617</th>\n",
       "      <th>618</th>\n",
       "      <th>619</th>\n",
       "      <th>620</th>\n",
       "      <th>621</th>\n",
       "      <th>622</th>\n",
       "      <th>623</th>\n",
       "      <th>624</th>\n",
       "      <th>625</th>\n",
       "      <th>626</th>\n",
       "      <th>627</th>\n",
       "      <th>628</th>\n",
       "      <th>629</th>\n",
       "      <th>630</th>\n",
       "      <th>631</th>\n",
       "      <th>632</th>\n",
       "      <th>633</th>\n",
       "      <th>634</th>\n",
       "      <th>635</th>\n",
       "      <th>636</th>\n",
       "      <th>637</th>\n",
       "      <th>638</th>\n",
       "      <th>639</th>\n",
       "      <th>640</th>\n",
       "      <th>641</th>\n",
       "      <th>642</th>\n",
       "      <th>643</th>\n",
       "      <th>644</th>\n",
       "      <th>645</th>\n",
       "      <th>646</th>\n",
       "      <th>647</th>\n",
       "      <th>648</th>\n",
       "      <th>649</th>\n",
       "      <th>650</th>\n",
       "      <th>651</th>\n",
       "      <th>652</th>\n",
       "      <th>653</th>\n",
       "      <th>654</th>\n",
       "      <th>655</th>\n",
       "      <th>656</th>\n",
       "      <th>657</th>\n",
       "      <th>658</th>\n",
       "      <th>659</th>\n",
       "      <th>660</th>\n",
       "      <th>661</th>\n",
       "      <th>662</th>\n",
       "      <th>663</th>\n",
       "      <th>664</th>\n",
       "      <th>665</th>\n",
       "      <th>666</th>\n",
       "      <th>667</th>\n",
       "      <th>668</th>\n",
       "      <th>669</th>\n",
       "      <th>670</th>\n",
       "      <th>671</th>\n",
       "      <th>672</th>\n",
       "      <th>673</th>\n",
       "      <th>674</th>\n",
       "      <th>675</th>\n",
       "      <th>676</th>\n",
       "      <th>677</th>\n",
       "      <th>678</th>\n",
       "      <th>679</th>\n",
       "      <th>680</th>\n",
       "      <th>681</th>\n",
       "      <th>682</th>\n",
       "      <th>683</th>\n",
       "      <th>684</th>\n",
       "      <th>685</th>\n",
       "      <th>686</th>\n",
       "      <th>687</th>\n",
       "      <th>688</th>\n",
       "      <th>689</th>\n",
       "      <th>690</th>\n",
       "      <th>691</th>\n",
       "      <th>692</th>\n",
       "      <th>693</th>\n",
       "      <th>694</th>\n",
       "      <th>695</th>\n",
       "      <th>696</th>\n",
       "      <th>697</th>\n",
       "      <th>698</th>\n",
       "      <th>699</th>\n",
       "      <th>700</th>\n",
       "      <th>701</th>\n",
       "      <th>702</th>\n",
       "      <th>703</th>\n",
       "      <th>704</th>\n",
       "      <th>705</th>\n",
       "      <th>706</th>\n",
       "      <th>707</th>\n",
       "      <th>708</th>\n",
       "      <th>709</th>\n",
       "      <th>710</th>\n",
       "      <th>711</th>\n",
       "      <th>712</th>\n",
       "      <th>713</th>\n",
       "      <th>714</th>\n",
       "      <th>715</th>\n",
       "      <th>716</th>\n",
       "      <th>717</th>\n",
       "      <th>718</th>\n",
       "      <th>719</th>\n",
       "      <th>720</th>\n",
       "      <th>721</th>\n",
       "      <th>722</th>\n",
       "      <th>723</th>\n",
       "      <th>724</th>\n",
       "      <th>725</th>\n",
       "      <th>726</th>\n",
       "      <th>727</th>\n",
       "      <th>728</th>\n",
       "      <th>729</th>\n",
       "      <th>730</th>\n",
       "      <th>731</th>\n",
       "      <th>732</th>\n",
       "      <th>733</th>\n",
       "      <th>734</th>\n",
       "      <th>735</th>\n",
       "      <th>736</th>\n",
       "      <th>737</th>\n",
       "      <th>738</th>\n",
       "      <th>739</th>\n",
       "      <th>740</th>\n",
       "      <th>741</th>\n",
       "      <th>742</th>\n",
       "      <th>743</th>\n",
       "      <th>744</th>\n",
       "      <th>745</th>\n",
       "      <th>746</th>\n",
       "      <th>747</th>\n",
       "      <th>748</th>\n",
       "      <th>749</th>\n",
       "      <th>750</th>\n",
       "      <th>751</th>\n",
       "      <th>752</th>\n",
       "      <th>753</th>\n",
       "      <th>754</th>\n",
       "      <th>755</th>\n",
       "      <th>756</th>\n",
       "      <th>757</th>\n",
       "      <th>758</th>\n",
       "      <th>759</th>\n",
       "      <th>760</th>\n",
       "      <th>761</th>\n",
       "      <th>762</th>\n",
       "      <th>763</th>\n",
       "      <th>764</th>\n",
       "      <th>765</th>\n",
       "      <th>766</th>\n",
       "      <th>767</th>\n",
       "      <th>768</th>\n",
       "      <th>769</th>\n",
       "      <th>770</th>\n",
       "      <th>771</th>\n",
       "      <th>772</th>\n",
       "      <th>773</th>\n",
       "      <th>774</th>\n",
       "      <th>775</th>\n",
       "      <th>776</th>\n",
       "      <th>777</th>\n",
       "      <th>778</th>\n",
       "      <th>779</th>\n",
       "      <th>780</th>\n",
       "      <th>781</th>\n",
       "      <th>782</th>\n",
       "      <th>783</th>\n",
       "      <th>784</th>\n",
       "      <th>785</th>\n",
       "      <th>786</th>\n",
       "      <th>787</th>\n",
       "      <th>788</th>\n",
       "      <th>789</th>\n",
       "      <th>790</th>\n",
       "      <th>791</th>\n",
       "      <th>792</th>\n",
       "      <th>793</th>\n",
       "      <th>794</th>\n",
       "      <th>795</th>\n",
       "      <th>796</th>\n",
       "      <th>797</th>\n",
       "      <th>798</th>\n",
       "      <th>799</th>\n",
       "      <th>800</th>\n",
       "      <th>801</th>\n",
       "      <th>802</th>\n",
       "      <th>803</th>\n",
       "      <th>804</th>\n",
       "      <th>805</th>\n",
       "      <th>806</th>\n",
       "      <th>807</th>\n",
       "      <th>808</th>\n",
       "      <th>809</th>\n",
       "      <th>810</th>\n",
       "      <th>811</th>\n",
       "      <th>812</th>\n",
       "      <th>813</th>\n",
       "      <th>814</th>\n",
       "      <th>815</th>\n",
       "      <th>816</th>\n",
       "      <th>817</th>\n",
       "      <th>818</th>\n",
       "      <th>819</th>\n",
       "      <th>820</th>\n",
       "      <th>821</th>\n",
       "      <th>822</th>\n",
       "      <th>823</th>\n",
       "      <th>824</th>\n",
       "      <th>825</th>\n",
       "      <th>826</th>\n",
       "      <th>827</th>\n",
       "      <th>828</th>\n",
       "      <th>829</th>\n",
       "      <th>830</th>\n",
       "      <th>831</th>\n",
       "      <th>832</th>\n",
       "      <th>833</th>\n",
       "      <th>834</th>\n",
       "      <th>835</th>\n",
       "      <th>836</th>\n",
       "      <th>837</th>\n",
       "      <th>838</th>\n",
       "      <th>839</th>\n",
       "      <th>840</th>\n",
       "      <th>841</th>\n",
       "      <th>842</th>\n",
       "      <th>843</th>\n",
       "      <th>844</th>\n",
       "      <th>845</th>\n",
       "      <th>846</th>\n",
       "      <th>847</th>\n",
       "      <th>848</th>\n",
       "      <th>849</th>\n",
       "      <th>850</th>\n",
       "      <th>851</th>\n",
       "      <th>852</th>\n",
       "      <th>853</th>\n",
       "      <th>854</th>\n",
       "      <th>855</th>\n",
       "      <th>856</th>\n",
       "      <th>857</th>\n",
       "      <th>858</th>\n",
       "      <th>859</th>\n",
       "      <th>860</th>\n",
       "      <th>861</th>\n",
       "      <th>862</th>\n",
       "      <th>863</th>\n",
       "      <th>864</th>\n",
       "      <th>865</th>\n",
       "      <th>866</th>\n",
       "      <th>867</th>\n",
       "      <th>868</th>\n",
       "      <th>869</th>\n",
       "      <th>870</th>\n",
       "      <th>871</th>\n",
       "      <th>872</th>\n",
       "      <th>873</th>\n",
       "      <th>874</th>\n",
       "      <th>875</th>\n",
       "      <th>876</th>\n",
       "      <th>877</th>\n",
       "      <th>878</th>\n",
       "      <th>879</th>\n",
       "      <th>880</th>\n",
       "      <th>881</th>\n",
       "      <th>882</th>\n",
       "      <th>883</th>\n",
       "      <th>884</th>\n",
       "      <th>885</th>\n",
       "      <th>886</th>\n",
       "      <th>887</th>\n",
       "      <th>888</th>\n",
       "      <th>889</th>\n",
       "      <th>890</th>\n",
       "      <th>891</th>\n",
       "      <th>892</th>\n",
       "      <th>893</th>\n",
       "      <th>894</th>\n",
       "      <th>895</th>\n",
       "      <th>896</th>\n",
       "      <th>897</th>\n",
       "      <th>898</th>\n",
       "      <th>899</th>\n",
       "      <th>900</th>\n",
       "      <th>901</th>\n",
       "      <th>902</th>\n",
       "      <th>903</th>\n",
       "      <th>904</th>\n",
       "      <th>905</th>\n",
       "      <th>906</th>\n",
       "      <th>907</th>\n",
       "      <th>908</th>\n",
       "      <th>909</th>\n",
       "      <th>910</th>\n",
       "      <th>911</th>\n",
       "      <th>912</th>\n",
       "      <th>913</th>\n",
       "      <th>914</th>\n",
       "      <th>915</th>\n",
       "      <th>916</th>\n",
       "      <th>917</th>\n",
       "      <th>918</th>\n",
       "      <th>919</th>\n",
       "      <th>920</th>\n",
       "      <th>921</th>\n",
       "      <th>922</th>\n",
       "      <th>923</th>\n",
       "      <th>924</th>\n",
       "      <th>925</th>\n",
       "      <th>926</th>\n",
       "      <th>927</th>\n",
       "      <th>928</th>\n",
       "      <th>929</th>\n",
       "      <th>930</th>\n",
       "      <th>931</th>\n",
       "      <th>932</th>\n",
       "      <th>933</th>\n",
       "      <th>934</th>\n",
       "      <th>935</th>\n",
       "      <th>936</th>\n",
       "      <th>937</th>\n",
       "      <th>938</th>\n",
       "      <th>939</th>\n",
       "      <th>940</th>\n",
       "      <th>941</th>\n",
       "      <th>942</th>\n",
       "      <th>943</th>\n",
       "      <th>944</th>\n",
       "      <th>945</th>\n",
       "      <th>946</th>\n",
       "      <th>947</th>\n",
       "      <th>948</th>\n",
       "      <th>949</th>\n",
       "      <th>950</th>\n",
       "      <th>951</th>\n",
       "      <th>952</th>\n",
       "      <th>953</th>\n",
       "      <th>954</th>\n",
       "      <th>955</th>\n",
       "      <th>956</th>\n",
       "      <th>957</th>\n",
       "      <th>958</th>\n",
       "      <th>959</th>\n",
       "      <th>960</th>\n",
       "      <th>961</th>\n",
       "      <th>962</th>\n",
       "      <th>963</th>\n",
       "      <th>964</th>\n",
       "      <th>965</th>\n",
       "      <th>966</th>\n",
       "      <th>967</th>\n",
       "      <th>968</th>\n",
       "      <th>969</th>\n",
       "      <th>970</th>\n",
       "      <th>971</th>\n",
       "      <th>972</th>\n",
       "      <th>973</th>\n",
       "      <th>974</th>\n",
       "      <th>975</th>\n",
       "      <th>976</th>\n",
       "      <th>977</th>\n",
       "      <th>978</th>\n",
       "      <th>979</th>\n",
       "      <th>980</th>\n",
       "      <th>981</th>\n",
       "      <th>982</th>\n",
       "      <th>983</th>\n",
       "      <th>984</th>\n",
       "      <th>985</th>\n",
       "      <th>986</th>\n",
       "      <th>987</th>\n",
       "      <th>988</th>\n",
       "      <th>989</th>\n",
       "      <th>990</th>\n",
       "      <th>991</th>\n",
       "      <th>992</th>\n",
       "      <th>993</th>\n",
       "      <th>994</th>\n",
       "      <th>995</th>\n",
       "      <th>996</th>\n",
       "      <th>997</th>\n",
       "      <th>998</th>\n",
       "      <th>999</th>\n",
       "      <th>1000</th>\n",
       "      <th>1001</th>\n",
       "      <th>1002</th>\n",
       "      <th>1003</th>\n",
       "      <th>1004</th>\n",
       "      <th>1005</th>\n",
       "      <th>1006</th>\n",
       "      <th>1007</th>\n",
       "      <th>1008</th>\n",
       "      <th>1009</th>\n",
       "      <th>1010</th>\n",
       "      <th>1011</th>\n",
       "      <th>1012</th>\n",
       "      <th>1013</th>\n",
       "      <th>1014</th>\n",
       "      <th>1015</th>\n",
       "      <th>1016</th>\n",
       "      <th>1017</th>\n",
       "      <th>1018</th>\n",
       "      <th>1019</th>\n",
       "      <th>1020</th>\n",
       "      <th>1021</th>\n",
       "      <th>1022</th>\n",
       "      <th>1023</th>\n",
       "      <th>1024</th>\n",
       "      <th>1025</th>\n",
       "      <th>1026</th>\n",
       "      <th>1027</th>\n",
       "      <th>1028</th>\n",
       "      <th>1029</th>\n",
       "      <th>1030</th>\n",
       "      <th>1031</th>\n",
       "      <th>1032</th>\n",
       "      <th>1033</th>\n",
       "      <th>1034</th>\n",
       "      <th>1035</th>\n",
       "      <th>1036</th>\n",
       "      <th>1037</th>\n",
       "      <th>1038</th>\n",
       "      <th>1039</th>\n",
       "      <th>1040</th>\n",
       "      <th>1041</th>\n",
       "      <th>1042</th>\n",
       "      <th>1043</th>\n",
       "      <th>1044</th>\n",
       "      <th>1045</th>\n",
       "      <th>1046</th>\n",
       "      <th>1047</th>\n",
       "      <th>1048</th>\n",
       "      <th>1049</th>\n",
       "      <th>1050</th>\n",
       "      <th>1051</th>\n",
       "      <th>1052</th>\n",
       "      <th>1053</th>\n",
       "      <th>1054</th>\n",
       "      <th>1055</th>\n",
       "      <th>1056</th>\n",
       "      <th>1057</th>\n",
       "      <th>1058</th>\n",
       "      <th>1059</th>\n",
       "      <th>1060</th>\n",
       "      <th>1061</th>\n",
       "      <th>1062</th>\n",
       "      <th>1063</th>\n",
       "      <th>1064</th>\n",
       "      <th>1065</th>\n",
       "      <th>1066</th>\n",
       "      <th>1067</th>\n",
       "      <th>1068</th>\n",
       "      <th>1069</th>\n",
       "      <th>1070</th>\n",
       "      <th>1071</th>\n",
       "      <th>1072</th>\n",
       "      <th>1073</th>\n",
       "      <th>1074</th>\n",
       "      <th>1075</th>\n",
       "      <th>1076</th>\n",
       "      <th>1077</th>\n",
       "      <th>1078</th>\n",
       "      <th>1079</th>\n",
       "      <th>1080</th>\n",
       "      <th>1081</th>\n",
       "      <th>1082</th>\n",
       "      <th>1083</th>\n",
       "      <th>1084</th>\n",
       "      <th>1085</th>\n",
       "      <th>1086</th>\n",
       "      <th>1087</th>\n",
       "      <th>1088</th>\n",
       "      <th>1089</th>\n",
       "      <th>1090</th>\n",
       "      <th>1091</th>\n",
       "      <th>1092</th>\n",
       "      <th>1093</th>\n",
       "      <th>1094</th>\n",
       "      <th>1095</th>\n",
       "      <th>1096</th>\n",
       "      <th>1097</th>\n",
       "      <th>1098</th>\n",
       "      <th>1099</th>\n",
       "      <th>1100</th>\n",
       "      <th>1101</th>\n",
       "      <th>1102</th>\n",
       "      <th>1103</th>\n",
       "      <th>1104</th>\n",
       "      <th>1105</th>\n",
       "      <th>1106</th>\n",
       "      <th>1107</th>\n",
       "      <th>1108</th>\n",
       "      <th>1109</th>\n",
       "      <th>1110</th>\n",
       "      <th>1111</th>\n",
       "      <th>1112</th>\n",
       "      <th>1113</th>\n",
       "      <th>1114</th>\n",
       "      <th>1115</th>\n",
       "      <th>1116</th>\n",
       "      <th>1117</th>\n",
       "      <th>1118</th>\n",
       "      <th>1119</th>\n",
       "      <th>1120</th>\n",
       "      <th>1121</th>\n",
       "      <th>1122</th>\n",
       "      <th>1123</th>\n",
       "      <th>1124</th>\n",
       "      <th>1125</th>\n",
       "      <th>1126</th>\n",
       "      <th>1127</th>\n",
       "      <th>1128</th>\n",
       "      <th>1129</th>\n",
       "      <th>1130</th>\n",
       "      <th>1131</th>\n",
       "      <th>1132</th>\n",
       "      <th>1133</th>\n",
       "      <th>1134</th>\n",
       "      <th>1135</th>\n",
       "      <th>1136</th>\n",
       "      <th>1137</th>\n",
       "      <th>1138</th>\n",
       "      <th>1139</th>\n",
       "      <th>1140</th>\n",
       "      <th>1141</th>\n",
       "      <th>1142</th>\n",
       "      <th>1143</th>\n",
       "      <th>1144</th>\n",
       "      <th>1145</th>\n",
       "      <th>1146</th>\n",
       "      <th>1147</th>\n",
       "      <th>1148</th>\n",
       "      <th>1149</th>\n",
       "      <th>1150</th>\n",
       "      <th>1151</th>\n",
       "      <th>1152</th>\n",
       "      <th>1153</th>\n",
       "      <th>1154</th>\n",
       "      <th>1155</th>\n",
       "      <th>1156</th>\n",
       "      <th>1157</th>\n",
       "      <th>1158</th>\n",
       "      <th>1159</th>\n",
       "      <th>1160</th>\n",
       "      <th>1161</th>\n",
       "      <th>1162</th>\n",
       "      <th>1163</th>\n",
       "      <th>1164</th>\n",
       "      <th>1165</th>\n",
       "      <th>1166</th>\n",
       "      <th>1167</th>\n",
       "      <th>1168</th>\n",
       "      <th>1169</th>\n",
       "      <th>1170</th>\n",
       "      <th>1171</th>\n",
       "      <th>1172</th>\n",
       "      <th>1173</th>\n",
       "      <th>1174</th>\n",
       "      <th>1175</th>\n",
       "      <th>1176</th>\n",
       "      <th>1177</th>\n",
       "      <th>1178</th>\n",
       "      <th>1179</th>\n",
       "      <th>1180</th>\n",
       "      <th>1181</th>\n",
       "      <th>1182</th>\n",
       "      <th>1183</th>\n",
       "      <th>1184</th>\n",
       "      <th>1185</th>\n",
       "      <th>1186</th>\n",
       "      <th>1187</th>\n",
       "      <th>1188</th>\n",
       "      <th>1189</th>\n",
       "      <th>1190</th>\n",
       "      <th>1191</th>\n",
       "      <th>1192</th>\n",
       "      <th>1193</th>\n",
       "      <th>1194</th>\n",
       "      <th>1195</th>\n",
       "      <th>1196</th>\n",
       "      <th>1197</th>\n",
       "      <th>1198</th>\n",
       "      <th>1199</th>\n",
       "      <th>1200</th>\n",
       "      <th>1201</th>\n",
       "      <th>1202</th>\n",
       "      <th>1203</th>\n",
       "      <th>1204</th>\n",
       "      <th>1205</th>\n",
       "      <th>1206</th>\n",
       "      <th>1207</th>\n",
       "      <th>1208</th>\n",
       "      <th>1209</th>\n",
       "      <th>1210</th>\n",
       "      <th>1211</th>\n",
       "      <th>1212</th>\n",
       "      <th>1213</th>\n",
       "      <th>1214</th>\n",
       "      <th>1215</th>\n",
       "      <th>1216</th>\n",
       "      <th>1217</th>\n",
       "      <th>1218</th>\n",
       "      <th>1219</th>\n",
       "      <th>1220</th>\n",
       "      <th>1221</th>\n",
       "      <th>1222</th>\n",
       "      <th>1223</th>\n",
       "      <th>1224</th>\n",
       "      <th>1225</th>\n",
       "      <th>1226</th>\n",
       "      <th>1227</th>\n",
       "      <th>1228</th>\n",
       "      <th>1229</th>\n",
       "      <th>1230</th>\n",
       "      <th>1231</th>\n",
       "      <th>1232</th>\n",
       "      <th>1233</th>\n",
       "      <th>1234</th>\n",
       "      <th>1235</th>\n",
       "      <th>1236</th>\n",
       "      <th>1237</th>\n",
       "      <th>1238</th>\n",
       "      <th>1239</th>\n",
       "      <th>1240</th>\n",
       "      <th>1241</th>\n",
       "      <th>1242</th>\n",
       "      <th>1243</th>\n",
       "      <th>1244</th>\n",
       "      <th>1245</th>\n",
       "      <th>1246</th>\n",
       "      <th>1247</th>\n",
       "      <th>1248</th>\n",
       "      <th>1249</th>\n",
       "      <th>1250</th>\n",
       "      <th>1251</th>\n",
       "      <th>1252</th>\n",
       "      <th>1253</th>\n",
       "      <th>1254</th>\n",
       "      <th>1255</th>\n",
       "      <th>1256</th>\n",
       "      <th>1257</th>\n",
       "      <th>1258</th>\n",
       "      <th>1259</th>\n",
       "      <th>1260</th>\n",
       "      <th>1261</th>\n",
       "      <th>1262</th>\n",
       "      <th>1263</th>\n",
       "      <th>1264</th>\n",
       "      <th>1265</th>\n",
       "      <th>1266</th>\n",
       "      <th>1267</th>\n",
       "      <th>1268</th>\n",
       "      <th>1269</th>\n",
       "      <th>1270</th>\n",
       "      <th>1271</th>\n",
       "      <th>1272</th>\n",
       "      <th>1273</th>\n",
       "      <th>1274</th>\n",
       "      <th>1275</th>\n",
       "      <th>1276</th>\n",
       "      <th>1277</th>\n",
       "      <th>1278</th>\n",
       "      <th>1279</th>\n",
       "      <th>1280</th>\n",
       "      <th>1281</th>\n",
       "      <th>1282</th>\n",
       "      <th>1283</th>\n",
       "      <th>1284</th>\n",
       "      <th>1285</th>\n",
       "      <th>1286</th>\n",
       "      <th>1287</th>\n",
       "      <th>1288</th>\n",
       "      <th>1289</th>\n",
       "      <th>1290</th>\n",
       "      <th>1291</th>\n",
       "      <th>1292</th>\n",
       "      <th>1293</th>\n",
       "      <th>1294</th>\n",
       "      <th>1295</th>\n",
       "      <th>1296</th>\n",
       "      <th>1297</th>\n",
       "      <th>1298</th>\n",
       "      <th>1299</th>\n",
       "      <th>1300</th>\n",
       "      <th>1301</th>\n",
       "      <th>1302</th>\n",
       "      <th>1303</th>\n",
       "      <th>1304</th>\n",
       "      <th>1305</th>\n",
       "      <th>1306</th>\n",
       "      <th>1307</th>\n",
       "      <th>1308</th>\n",
       "      <th>1309</th>\n",
       "      <th>1310</th>\n",
       "      <th>1311</th>\n",
       "      <th>1312</th>\n",
       "      <th>1313</th>\n",
       "      <th>1314</th>\n",
       "      <th>1315</th>\n",
       "      <th>1316</th>\n",
       "      <th>1317</th>\n",
       "      <th>1318</th>\n",
       "      <th>1319</th>\n",
       "      <th>1320</th>\n",
       "      <th>1321</th>\n",
       "      <th>1322</th>\n",
       "      <th>1323</th>\n",
       "      <th>1324</th>\n",
       "      <th>1325</th>\n",
       "      <th>1326</th>\n",
       "      <th>1327</th>\n",
       "      <th>1328</th>\n",
       "      <th>1329</th>\n",
       "      <th>1330</th>\n",
       "      <th>1331</th>\n",
       "      <th>1332</th>\n",
       "      <th>1333</th>\n",
       "      <th>1334</th>\n",
       "      <th>1335</th>\n",
       "      <th>1336</th>\n",
       "      <th>1337</th>\n",
       "      <th>1338</th>\n",
       "      <th>1339</th>\n",
       "      <th>1340</th>\n",
       "      <th>1341</th>\n",
       "      <th>1342</th>\n",
       "      <th>1343</th>\n",
       "      <th>1344</th>\n",
       "      <th>1345</th>\n",
       "      <th>1346</th>\n",
       "      <th>1347</th>\n",
       "      <th>1348</th>\n",
       "      <th>1349</th>\n",
       "      <th>1350</th>\n",
       "      <th>1351</th>\n",
       "      <th>1352</th>\n",
       "      <th>1353</th>\n",
       "      <th>1354</th>\n",
       "      <th>1355</th>\n",
       "      <th>1356</th>\n",
       "      <th>1357</th>\n",
       "      <th>1358</th>\n",
       "      <th>1359</th>\n",
       "      <th>1360</th>\n",
       "      <th>1361</th>\n",
       "      <th>1362</th>\n",
       "      <th>1363</th>\n",
       "      <th>1364</th>\n",
       "      <th>1365</th>\n",
       "      <th>1366</th>\n",
       "      <th>1367</th>\n",
       "      <th>1368</th>\n",
       "      <th>1369</th>\n",
       "      <th>1370</th>\n",
       "      <th>1371</th>\n",
       "      <th>1372</th>\n",
       "      <th>1373</th>\n",
       "      <th>1374</th>\n",
       "      <th>1375</th>\n",
       "      <th>1376</th>\n",
       "      <th>1377</th>\n",
       "      <th>1378</th>\n",
       "      <th>1379</th>\n",
       "      <th>1380</th>\n",
       "      <th>1381</th>\n",
       "      <th>1382</th>\n",
       "      <th>1383</th>\n",
       "      <th>1384</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <td>0</td>\n",
       "      <td>DB00220</td>\n",
       "      <td>nelfinavir</td>\n",
       "      <td>4451</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>1</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
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       "      <td>0</td>\n",
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       "    </tr>\n",
       "    <tr>\n",
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       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "  drugBankID    drugName  compoundID  0  1  2  3  4  5  6  7  8  9 10 11 12  \\\n",
       "0    DB00220  nelfinavir        4451  0  0  1  0  0  0  0  0  0  0  0  0  0   \n",
       "1    DB01340  cilazapril        2751  0  0  1  0  0  0  0  0  0  0  0  0  0   \n",
       "\n",
       "  13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37  \\\n",
       "0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  0   \n",
       "1  0  0  0  0  0  0  1  0  0  0  0  0  0  0  1  0  0  0  0  0  0  0  0  1  0   \n",
       "\n",
       "  38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62  \\\n",
       "0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  0  1  0  0  0  0  0  0  0  0  0   \n",
       "1  1  0  0  0  0  0  0  0  0  1  0  0  0  1  0  1  0  0  0  0  0  0  0  0  0   \n",
       "\n",
       "  63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87  \\\n",
       "0  0  0  0  0  1  1  0  0  0  0  0  1  0  0  0  0  0  0  0  0  0  1  0  0  0   \n",
       "1  1  0  0  0  1  0  0  0  0  0  0  1  0  0  0  1  0  0  1  0  1  0  0  0  0   \n",
       "\n",
       "  88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109  \\\n",
       "0  0  0  0  0  0  0  0  0  0  0  0  0   0   0   0   0   0   0   0   0   0   0   \n",
       "1  0  0  0  0  0  0  0  0  0  0  0  0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128  \\\n",
       "0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   1   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   \n",
       "\n",
       "  148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   1   1   0   1   0   0   0   0   0   0   \n",
       "\n",
       "  186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   \n",
       "1   0   0   0   1   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "\n",
       "  205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223  \\\n",
       "0   0   0   1   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242  \\\n",
       "0   1   0   0   1   0   1   0   0   0   0   0   0   0   0   0   0   1   1   0   \n",
       "1   1   0   0   1   0   1   0   0   0   0   0   0   0   0   0   0   1   1   0   \n",
       "\n",
       "  243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261  \\\n",
       "0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   1   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   \n",
       "1   0   0   0   0   1   0   0   0   0   0   0   0   1   0   0   1   0   0   0   \n",
       "\n",
       "  281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299  \\\n",
       "0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   1   0   0   0   0   0   0   0   0   0   1   0   0   0   0   \n",
       "\n",
       "  300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318  \\\n",
       "0   1   0   0   0   0   0   0   0   0   1   0   0   0   1   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   1   0   1   0   0   0   0   0   0   0   \n",
       "\n",
       "  319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337  \\\n",
       "0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356  \\\n",
       "0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   \n",
       "1   1   0   0   0   0   0   0   0   1   0   0   0   0   0   1   0   1   0   0   \n",
       "\n",
       "  357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394  \\\n",
       "0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432  \\\n",
       "0   0   0   0   1   0   0   1   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "1   0   0   0   1   0   1   0   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "\n",
       "  433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451  \\\n",
       "0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   1   0   0   0   \n",
       "\n",
       "  452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   \n",
       "1   0   0   0   1   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489  \\\n",
       "0   1   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   1   1   0   0   0   0   0   0   0   \n",
       "\n",
       "  490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   \n",
       "1   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   1   \n",
       "\n",
       "  509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   \n",
       "\n",
       "  528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584  \\\n",
       "0   0   0   0   0   0   0   0   0   0   1   0   1   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   \n",
       "1   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   \n",
       "\n",
       "  604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   1   0   0   0   0   0   0   1   0   0   0   0   0   0   0   \n",
       "\n",
       "  623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660  \\\n",
       "0   0   0   0   0   0   0   0   1   0   0   0   1   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   1   0   1   0   1   0   0   0   0   0   0   0   \n",
       "\n",
       "  661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679  \\\n",
       "0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   1   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698  \\\n",
       "0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 716 717  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   \n",
       "\n",
       "  718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   1   0   0   \n",
       "\n",
       "  737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755  \\\n",
       "0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "\n",
       "  756 757 758 759 760 761 762 763 764 765 766 767 768 769 770 771 772 773 774  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 790 791 792 793  \\\n",
       "0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   1   \n",
       "\n",
       "  794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812  \\\n",
       "0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   1   0   0   0   \n",
       "\n",
       "  813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 828 829 830 831  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "\n",
       "  832 833 834 835 836 837 838 839 840 841 842 843 844 845 846 847 848 849 850  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   1   0   0   0   0   0   0   0   0   1   0   0   1   0   0   0   \n",
       "\n",
       "  851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 867 868 869  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  870 871 872 873 874 875 876 877 878 879 880 881 882 883 884 885 886 887 888  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   1   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "\n",
       "  889 890 891 892 893 894 895 896 897 898 899 900 901 902 903 904 905 906 907  \\\n",
       "0   0   0   0   1   0   0   0   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   1   0   0   0   0   0   0   1   0   0   0   0   0   \n",
       "\n",
       "  908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   1   0   0   0   0   0   0   0   0   1   0   0   0   0   0   1   0   \n",
       "\n",
       "  927 928 929 930 931 932 933 934 935 936 937 938 939 940 941 942 943 944 945  \\\n",
       "0   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   1   0   0   0   0   0   0   0   1   0   0   0   \n",
       "\n",
       "  946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   1   \n",
       "\n",
       "  965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   \n",
       "\n",
       "  984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 1001  \\\n",
       "0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0    0    1   \n",
       "1   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0    0    0   \n",
       "\n",
       "  1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016  \\\n",
       "0    0    0    0    0    0    0    0    0    0    1    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    1    0    0    0    0    0   \n",
       "\n",
       "  1017 1018 1019 1020 1021 1022 1023 1024 1025 1026 1027 1028 1029 1030 1031  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    1    0   \n",
       "\n",
       "  1032 1033 1034 1035 1036 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046  \\\n",
       "0    1    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1062 1063 1064 1065 1066 1067 1068 1069 1070 1071 1072 1073 1074 1075 1076  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1102 1103 1104 1105 1106  \\\n",
       "0    0    0    0    0    1    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    1    0    1    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    1    0    1    0    0   \n",
       "\n",
       "  1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 1136  \\\n",
       "0    0    0    0    0    1    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1152 1153 1154 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1167 1168 1169 1170 1171 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1197 1198 1199 1200 1201 1202 1203 1204 1205 1206 1207 1208 1209 1210 1211  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    1    0   \n",
       "\n",
       "  1212 1213 1214 1215 1216 1217 1218 1219 1220 1221 1222 1223 1224 1225 1226  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1227 1228 1229 1230 1231 1232 1233 1234 1235 1236 1237 1238 1239 1240 1241  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1242 1243 1244 1245 1246 1247 1248 1249 1250 1251 1252 1253 1254 1255 1256  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    1    0    0    0   \n",
       "\n",
       "  1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 1271  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    1    0    1    0   \n",
       "\n",
       "  1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1283 1284 1285 1286  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1287 1288 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 1301  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    1    0    0    0    0    0   \n",
       "\n",
       "  1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    1    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331  \\\n",
       "0    0    0    0    0    0    0    0    0    0    1    0    0    0    0    0   \n",
       "1    0    0    0    0    1    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1332 1333 1334 1335 1336 1337 1338 1339 1340 1341 1342 1343 1344 1345 1346  \\\n",
       "0    0    0    0    0    0    0    1    0    0    0    0    0    0    0    1   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    1   \n",
       "\n",
       "  1347 1348 1349 1350 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1362 1363 1364 1365 1366 1367 1368 1369 1370 1371 1372 1373 1374 1375 1376  \\\n",
       "0    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "1    0    0    0    0    0    0    0    0    0    0    0    0    0    0    0   \n",
       "\n",
       "  1377 1378 1379 1380 1381 1382 1383 1384  \n",
       "0    0    1    0    0    0    0    0    0  \n",
       "1    0    0    1    0    0    0    0    0  "
      ]
     },
     "execution_count": 44,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "side_effect_binary1=pd.concat([side_effect_binary1, se_binary_ade], axis=1)\n",
    "side_effect_binary1.head(2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 213,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "832"
      ]
     },
     "execution_count": 213,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "side_effect_binary.drugName.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 233,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(832, 11)"
      ]
     },
     "execution_count": 233,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "side_effect_binary.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#remove group_str from side_effect_binary"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#merge side_effect_binary with drug_meddra"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "ADE= adverse drug event"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#merge TWO_sides with side_effect_binary data"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Load DrugBank dataset if access provided"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 265,
   "metadata": {},
   "outputs": [],
   "source": [
    "#import DrugBank dataset\n",
    "import xml.etree.ElementTree as et "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 267,
   "metadata": {},
   "outputs": [],
   "source": [
    "xtree = et.parse(\"data/full_drugbank_database.xml\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 268,
   "metadata": {},
   "outputs": [],
   "source": [
    "def parse_XML(xml_file, df_cols): \n",
    "    \"\"\"Parse the input XML file and store the result in a pandas \n",
    "    DataFrame with the given columns. \n",
    "    \n",
    "    The first element of df_cols is supposed to be the identifier \n",
    "    variable, which is an attribute of each node element in the \n",
    "    XML data; other features will be parsed from the text content \n",
    "    of each sub-element. \n",
    "    \"\"\"\n",
    "    \n",
    "    xtree = et.parse(xml_file)\n",
    "    xroot = xtree.getroot()\n",
    "    rows = []\n",
    "    \n",
    "    for node in xroot: \n",
    "        res = []\n",
    "        res.append(node.attrib.get(df_cols[0]))\n",
    "        for el in df_cols[1:]: \n",
    "            if node is not None and node.find(el) is not None:\n",
    "                res.append(node.find(el).text)\n",
    "            else: \n",
    "                res.append(None)\n",
    "        rows.append({df_cols[i]: res[i] \n",
    "                     for i, _ in enumerate(df_cols)})\n",
    "    \n",
    "    out_df = pd.DataFrame(rows, columns=df_cols)\n",
    "        \n",
    "    return out_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "parse_XML(\"data/full_drugbank_database.xml\", ['name', 'id', 'description', 'cas-number'])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Data Exploration\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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