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Look into source code of BEAGLE 4.1 #138

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szhan opened this issue Jun 26, 2023 · 3 comments
Closed

Look into source code of BEAGLE 4.1 #138

szhan opened this issue Jun 26, 2023 · 3 comments

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@szhan
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szhan commented Jun 26, 2023

I should know a bit better the nitty-gritty details of the LS HMM implementation of BEAGLE 4.1. The source code (Java) of BEAGLE 4.1 is not available (download link) when I checked, so I've emailed Brian Browning for a copy.

@szhan
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szhan commented Jun 26, 2023

The broken link is now fixed.

@szhan
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szhan commented Jun 29, 2023

In the BEAGLE 4.1 paper, it states that an allelic error rate of 1-e04 is used. This should reflects sequencing error in NGS data. And it should be much higher than the generational mutation rate in humans (in the order of magnitude of 1e-08). So, I'm going to try using the parameter combination of r = 1e-08 and m = 1e-04 in the next run to see if I get better imputation results.

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szhan commented Jun 29, 2023

This thread is better moved to https://github.com/szhan/onekg_analysis.

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