This repository contains custom codes used for the Multi electrode array (MEA) data analysis for the paper:
Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons
by
Tatsuya Osaki (1,2,9) Tomoya Duenki (1,2,3,5,9), Siu Yu A. Chow (1,2,9), Yasuhiro Ikegami(1,2), Romain Beaubois (1,4,5), Timothée Levi (1,4,5), Nao Nakagawa-Tamagawa (6), Yoji Hirano (1,7,8), Yoshiho Ikeuchi (1,2,3,5*)
1 Institute of Industrial Science, The University of Tokyo, Meguro, Tokyo 153-8505, Japan. 2 Institute for AI and Beyond, The University of Tokyo, Bunkyo, Tokyo 113-8655, Japan. 3 Department of Chemistry and Biotechnology, The University of Tokyo, Bunkyo, Tokyo 113-8655, Japan. 4 IMS Laboratory, UMR5218, University of Bordeaux, Talence, France 5 LIMMS/CNRS, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan 6 Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan 7 Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 8 Department of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan 9 Equal contribution
It contains:
- Preprocessing of data
- Spike detection
- Burst detection
- Neuronal avalanches
- Wavelet transformation and coherence
- Integral Power
- Phase-amplitude coupling
All analysis were performed using MATLAB 2020a. Example signal trace from a recording can be found and analyzed using the main script main.m to compute the parameters above.