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dat.nielweise2008.html
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dat.nielweise2008.html
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<h1>Studies on Anti-Infective-Treated Central Venous Catheters for Prevention of Catheter-Related Bloodstream Infections</h1>
<div class="hidden name"><code>dat.nielweise2008.Rd</code></div>
</div>
<div class="ref-description">
<p>Results from 18 studies comparing the risk of catheter-related bloodstream infection when using anti-infective-treated versus standard catheters for total parenteral nutrition or chemotherapy.</p>
</div>
<pre class="usage"><span class='no'>dat.nielweise2008</span></pre>
<h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2>
<p>The data frame contains the following columns:</p><table class='table'>
<tr><td><b>study</b></td><td><code>numeric</code></td><td>study number</td></tr>
<tr><td><b>authors</b></td><td><code>character</code></td><td>study authors</td></tr>
<tr><td><b>year</b></td><td><code>numeric</code></td><td>publication year</td></tr>
<tr><td><b>x1i</b></td><td><code>numeric</code></td><td>number of CRBSIs in patients receiving an anti-infective catheter</td></tr>
<tr><td><b>t1i</b></td><td><code>numeric</code></td><td>total number of catheter days for patients receiving an anti-infective catheter</td></tr>
<tr><td><b>x2i</b></td><td><code>numeric</code></td><td>number of CRBSIs in patients receiving a standard catheter</td></tr>
<tr><td><b>t2i</b></td><td><code>numeric</code></td><td>total number of catheter days for patients receiving a standard catheter</td></tr>
</table>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p>The use of a central venous catheter may lead to a catheter-related bloodstream infection (CRBSI), which in turn increases the risk of morbidity and mortality. Anti-infective-treated catheters have been developed that are meant to reduce the risk of CRBSIs. Niel-Weise et al. (2008) conducted a meta-analysis of studies comparing infection risk when using anti-infective-treated versus standard catheters for total parenteral nutrition or chemotherapy. The results from 9 such studies are included in this dataset.</p>
<p>The dataset was used in the article by Stijnen et al. (2010) to illustrate various generalized linear mixed-effects models for the meta-analysis of incidence rates and incidence rate ratios (see ‘References’).</p>
<h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2>
<p>Niel-Weise, B. S., Stijnen, T., & van den Broek, P. J. (2008). Anti-infective-treated central venous catheters for total parenteral nutrition or chemotherapy: A systematic review. <em>Journal of Hospital Infection</em>, <b>69</b>, 114--123.</p>
<h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
<p>Stijnen, T., Hamza, T. H., & Ozdemir, P. (2010). Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data. <em>Statistics in Medicine</em>, <b>29</b>, 3046--3067.</p>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'>### load data</span>
<span class='no'>dat</span> <span class='kw'><-</span> <span class='fu'>get</span>(<span class='fu'>data</span>(<span class='no'>dat.nielweise2008</span>))
<span class='co'>### standard (inverse-variance) random-effects model</span>
<span class='no'>res</span> <span class='kw'><-</span> <span class='fu'><a href='rma.uni.html'>rma</a></span>(<span class='kw'>measure</span><span class='kw'>=</span><span class='st'>"IRR"</span>, <span class='kw'>x1i</span><span class='kw'>=</span><span class='no'>x1i</span>, <span class='kw'>t1i</span><span class='kw'>=</span><span class='no'>t1i</span>, <span class='kw'>x2i</span><span class='kw'>=</span><span class='no'>x2i</span>, <span class='kw'>t2i</span><span class='kw'>=</span><span class='no'>t2i</span>, <span class='kw'>data</span><span class='kw'>=</span><span class='no'>dat</span>)
<span class='fu'>print</span>(<span class='no'>res</span>, <span class='kw'>digits</span><span class='kw'>=</span><span class='fl'>3</span>)</div><div class='output co'>#>
#> Random-Effects Model (k = 9; tau^2 estimator: REML)
#>
#> tau^2 (estimated amount of total heterogeneity): 0.094 (SE = 0.212)
#> tau (square root of estimated tau^2 value): 0.306
#> I^2 (total heterogeneity / total variability): 20.88%
#> H^2 (total variability / sampling variability): 1.26
#>
#> Test for Heterogeneity:
#> Q(df = 8) = 9.698, p-val = 0.287
#>
#> Model Results:
#>
#> estimate se zval pval ci.lb ci.ub
#> -0.396 0.227 -1.747 0.081 -0.841 0.048 .
#>
#> ---
#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
#> </div><div class='input'><span class='fu'>predict</span>(<span class='no'>res</span>, <span class='kw'>transf</span><span class='kw'>=</span><span class='no'>exp</span>, <span class='kw'>digits</span><span class='kw'>=</span><span class='fl'>2</span>)</div><div class='output co'>#>
#> pred ci.lb ci.ub cr.lb cr.ub
#> 0.67 0.43 1.05 0.32 1.42
#> </div><div class='input'>
### random-effects conditional Poisson model
</div><span class='co'># NOT RUN {</span>
<span class='no'>res</span> <span class='kw'><-</span> <span class='fu'><a href='rma.glmm.html'>rma.glmm</a></span>(<span class='kw'>measure</span><span class='kw'>=</span><span class='st'>"IRR"</span>, <span class='kw'>x1i</span><span class='kw'>=</span><span class='no'>x1i</span>, <span class='kw'>t1i</span><span class='kw'>=</span><span class='no'>t1i</span>, <span class='kw'>x2i</span><span class='kw'>=</span><span class='no'>x2i</span>, <span class='kw'>t2i</span><span class='kw'>=</span><span class='no'>t2i</span>, <span class='kw'>data</span><span class='kw'>=</span><span class='no'>dat</span>, <span class='kw'>model</span><span class='kw'>=</span><span class='st'>"CM.EL"</span>)
<span class='fu'>print</span>(<span class='no'>res</span>, <span class='kw'>digits</span><span class='kw'>=</span><span class='fl'>3</span>)
<span class='fu'>predict</span>(<span class='no'>res</span>, <span class='kw'>transf</span><span class='kw'>=</span><span class='no'>exp</span>, <span class='kw'>digits</span><span class='kw'>=</span><span class='fl'>2</span>)
<span class='co'># }</span></pre>
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<h2>Contents</h2>
<ul class="nav nav-pills nav-stacked">
<li><a href="#format">Format</a></li>
<li><a href="#details">Details</a></li>
<li><a href="#source">Source</a></li>
<li><a href="#references">References</a></li>
<li><a href="#examples">Examples</a></li>
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