Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
Add updates up until 2023-09-26 19:54:53
- Loading branch information
ggserver
committed
Sep 26, 2023
1 parent
60a0bbf
commit e02105c
Showing
1 changed file
with
94 additions
and
0 deletions.
There are no files selected for viewing
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,94 @@ | ||
<document id="42A94193A460A9664819791C70E6B8DC" ID-CLB-Dataset="58680" ID-DOI="10.1016/j.phytochem.2021.113024" ID-GBIF-Dataset="05f95d8a-c92f-423f-8517-ffa0fa7af90c" ID-ISSN="1873-3700" ID-Zenodo-Dep="8194471" IM.illustrations_approvedBy="diego" IM.materialsCitations_approvedBy="diego" IM.tables_approvedBy="diego" IM.treatments_approvedBy="diego" checkinTime="1690596726138" checkinUser="felipe" docAuthor="Chakraborty, Kajal & Dhara, Shubhajit" docDate="2022" docId="038887E3FFC16E0892524F3EFE846C72" docLanguage="en" docName="Phytochemistry.195.113024.pdf" docOrigin="Phytochemistry (113024) 195" docSource="http://dx.doi.org/10.1016/j.phytochem.2021.113024" docStyle="DocumentStyle:F36D69FC8B198FBE91029DF9C24697D3.6:Phytochemistry.2020-.journal_article" docStyleId="F36D69FC8B198FBE91029DF9C24697D3" docStyleName="Phytochemistry.2020-.journal_article" docStyleVersion="6" docTitle="Turbinaria ornata J. Agardh 1848" docType="treatment" docVersion="4" lastPageNumber="5" masterDocId="FFB1FF9BFFC56E0C91604E02FD1A6F37" masterDocTitle="Spirornatas A-C from brown alga Turbinaria ornata: Anti-hypertensive spiroketals attenuate angiotensin-I converting enzyme" masterLastPageNumber="10" masterPageNumber="1" pageNumber="5" updateTime="1695758074610" updateUser="diego"> | ||
<mods:mods id="6E1CF47FBC31943D8078BC17E1DB01D1" xmlns:mods="http://www.loc.gov/mods/v3"> | ||
<mods:titleInfo id="9A301444FF4FE51C1608A4858EACEFE3"> | ||
<mods:title id="9D15B1D86B5975201FFEEAAB70A97CDE">Spirornatas A-C from brown alga Turbinaria ornata: Anti-hypertensive spiroketals attenuate angiotensin-I converting enzyme</mods:title> | ||
</mods:titleInfo> | ||
<mods:name id="AC786E56BCB5101F29B667983AEF1410" type="personal"> | ||
<mods:role id="3AD38A35A2A6FF491F7D24BE8235B979"> | ||
<mods:roleTerm id="180AF1FF38224184E457EEF41C416E89">Author</mods:roleTerm> | ||
</mods:role> | ||
<mods:namePart id="A345CB8A5438A0E5FCE4033464E3506D">Chakraborty, Kajal</mods:namePart> | ||
<mods:affiliation id="DA57C79D0D1998015DC800F422C3A332">*, Shubhajit Dhara & Marine Bioprospecting Section of Marine Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P. B. No. 1603, Cochin, India</mods:affiliation> | ||
</mods:name> | ||
<mods:name id="9931258C5916E4ED16374AFC1A545C52" type="personal"> | ||
<mods:role id="6A1FE73C112ABB28418664F6F9C0C66F"> | ||
<mods:roleTerm id="DDD12D84B8D3C0C664E1A9422CA08743">Author</mods:roleTerm> | ||
</mods:role> | ||
<mods:namePart id="807E15F7575F669C2090E7B152CBA81B">Dhara, Shubhajit</mods:namePart> | ||
</mods:name> | ||
<mods:typeOfResource id="278FBC775EF3B645E6621B3389984052">text</mods:typeOfResource> | ||
<mods:relatedItem id="81A4342715DF6433392A69A7735F08B3" type="host"> | ||
<mods:titleInfo id="88EF649E3715CF32D3670E50ED096DAC"> | ||
<mods:title id="B625B96686D89A0EF583A4A3AE06ADB6">Phytochemistry</mods:title> | ||
</mods:titleInfo> | ||
<mods:part id="98907B37E8E5B73B06418661A300306E"> | ||
<mods:date id="C5F67B6B1DBA11AEA2419551B0038A30">2022</mods:date> | ||
<mods:detail id="EB6073A8ACC9795931C0D5EFAB1B8F36" type="series"> | ||
<mods:title id="26081CB5A99F1CEA1DEDB5EACC7E708B">113024</mods:title> | ||
</mods:detail> | ||
<mods:detail id="B1E388F4F25CA5B1C97AB65B85D41C60" type="pubDate"> | ||
<mods:number id="6990C00A3E0CFDEE824C76EDAE350280">2022-03-31</mods:number> | ||
</mods:detail> | ||
<mods:detail id="89B0F289D1A9E4DBBC6ACC8334D9ECFC" type="volume"> | ||
<mods:number id="A7E7DDD0FAEBB7210890A2F418B4D44A">195</mods:number> | ||
</mods:detail> | ||
<mods:extent id="D404215B80243DAC62FEE701375E7575" unit="page"> | ||
<mods:start id="681858330CCBE7FEA9779A98A20DF809">1</mods:start> | ||
<mods:end id="227DC2574275926B417F82FA8B7E20EE">10</mods:end> | ||
</mods:extent> | ||
</mods:part> | ||
</mods:relatedItem> | ||
<mods:location id="C30B2B247E66DBEE3A48956E8E166654"> | ||
<mods:url id="8AFF833093F61A7D7FE76481FD97B854">http://dx.doi.org/10.1016/j.phytochem.2021.113024</mods:url> | ||
</mods:location> | ||
<mods:classification id="AD5A5525B467300607B85510342BF908">journal article</mods:classification> | ||
<mods:identifier id="F3B4D6717D02DD8238124F8D4EAEEE1F" type="CLB-Dataset">58680</mods:identifier> | ||
<mods:identifier id="99C6D5F3AC7BB4C32FADF7439871ED43" type="DOI">10.1016/j.phytochem.2021.113024</mods:identifier> | ||
<mods:identifier id="A83433F1510674ECFB5A2E8AFADAA3CD" type="GBIF-Dataset">05f95d8a-c92f-423f-8517-ffa0fa7af90c</mods:identifier> | ||
<mods:identifier id="E54EDFFD589C70B83AF0D42B21A5219A" type="ISSN">1873-3700</mods:identifier> | ||
<mods:identifier id="C8D492974D4C990130933372A8AABE0B" type="Zenodo-Dep">8194471</mods:identifier> | ||
</mods:mods> | ||
<treatment id="038887E3FFC16E0892524F3EFE846C72" ID-GBIF-Taxon="212422925" LSID="urn:lsid:plazi:treatment:038887E3FFC16E0892524F3EFE846C72" httpUri="http://treatment.plazi.org/id/038887E3FFC16E0892524F3EFE846C72" lastPageNumber="5" pageId="4" pageNumber="5"> | ||
<subSubSection id="C33B657EFFC16E0892524F3EF89F6E78" box="[818,1413,315,335]" pageId="4" pageNumber="5" type="nomenclature"> | ||
<paragraph id="8B9E36F5FFC16E0892524F3EF89F6E78" blockId="4.[818,1413,315,335]" box="[818,1413,315,335]" pageId="4" pageNumber="5"> | ||
<heading id="D0D68199FFC16E0892524F3EF89F6E78" bold="true" box="[818,1413,315,335]" fontSize="36" level="1" pageId="4" pageNumber="5" reason="1"> | ||
<emphasis id="B955EAE7FFC16E0892524F3EF89F6E78" bold="true" box="[818,1413,315,335]" italics="true" pageId="4" pageNumber="5"> | ||
2.3. Bioactive potentials of the spiroketals isolated from | ||
<taxonomicName id="4C214D76FFC16E0894514F3EF89F6E78" authorityName="J. Agardh" authorityYear="1848" baseAuthorityName="Turner" box="[1329,1413,316,335]" class="Phaeophyceae" family="Sargassaceae" genus="Turbinaria" kingdom="Chromista" order="Fucales" pageId="4" pageNumber="5" phylum="Ochrophyta" rank="species" species="ornata">T. ornata</taxonomicName> | ||
</emphasis> | ||
</heading> | ||
</paragraph> | ||
</subSubSection> | ||
<subSubSection id="C33B657EFFC16E0892314F71FE846C72" pageId="4" pageNumber="5" type="description"> | ||
<paragraph id="8B9E36F5FFC16E0892314F71FE846C72" blockId="4.[818,1487,371,837]" pageId="4" pageNumber="5"> | ||
Spirornata A showed noticeably greater ACE-I inhibitory property (IC | ||
<subScript id="17A534B0FFC16E08922E4F94FE7A6E93" attach="left" box="[846,864,406,420]" fontSize="6" pageId="4" pageNumber="5">50</subScript> | ||
4.55 μM) compared to those exhibited by spirornata B (IC | ||
<subScript id="17A534B0FFC16E0894EC4F94F8846E93" attach="left" box="[1420,1438,406,420]" fontSize="6" pageId="4" pageNumber="5">50</subScript> | ||
4.72 μM) and C (IC | ||
<subScript id="17A534B0FFC16E0892A24FB0FECE6EF7" attach="left" box="[962,980,434,448]" fontSize="6" pageId="4" pageNumber="5">50</subScript> | ||
4.86 μM), as well as comparable activity with the standard ACE-I inhibitor, captopril (IC | ||
<subScript id="17A534B0FFC16E0895FE4FCCF9AA6EEB" attach="left" box="[1182,1200,462,476]" fontSize="6" pageId="4" pageNumber="5">50</subScript> | ||
4.29 μM) ( | ||
<tableCitation id="C6A3034EFFC16E08947D4FC5F87E6EED" box="[1309,1380,455,474]" captionStart="Table 2" captionStartId="5.[100,150,150,166]" captionTargetPageId="5" captionText="Table 2 Bioactivities of spirornatas A-C isolated from the organic extract of T. ornata and their molecular descriptors. Bioactivities (IC50) Spirornata A Spirornata B Spirornata C Standards Anti-hypertensive activity a ACE-I inhibition 4.55b ± 0.02 4.72 a ± 0.04 4.86 a ± 0.02 4.29 c ± 0.02CP – Antioxidant activitiesb DPPH. scavenging 1.14c ± 0.05 1.25b ± 0.02 1.42a ± 0.02 1.46a ± 0.04P – ABTS +. scavenging 1.28 c ± 0.01 1.34b ± 0.02 1.71 a ± 0.04 1.69 a ± 0.05 P – Molecular descriptors c Spirornata A Spirornata B Spirornata C α-tocopherol Captopril Electronic TPSA 71.06 88.13 61.83 29.46 57.61 PI (× 10 24 cm3) 41 43 45 53.54 21.00 Steric MR (cm3/mol) 105.84 110.83 119.80 135.6 54.85 MV (cm3) 348.9 353.2 357.7 462.70 170.7 P (cm3) 882.4 917.7 952 1123.00 463.4 Hydrophobic Log POW 3.22 1.69 2.75 9.98 0.24 Different superscripts indicate the standards used for different activities; P-α-tocopherol; CP-captopril. a Bioactivities were expressed as IC values (μM). Samples were analyzed in triplicate (n = 3) and expressed as mean ± standard deviation. Means followed by 50 different superscripts (a-c) within the same row indicated significant differences (P <0.05). The superscript "CP" designates the standard captopril. b IC values (mM). The superscript "P" indicates the standard α-tocopherol. 50 c Structure-activity relationship analysis was carried out by using different molecular descriptors of the purified compounds as described in the text. tPSA, topological polar surface area; MV, molar volume; P, parachor; MR, molar refractivity; Log POW, logarithmic scale of the octanol-water partition coefficient; PI, polarizability." pageId="4" pageNumber="5">Table 2</tableCitation> | ||
). The electronegative groups in the oxodecahydrospiro [furo-3,4-c] pyran-7, 2 | ||
<emphasis id="B955EAE7FFC16E0894A44FE0F8D26EC1" bold="true" box="[1476,1480,482,502]" pageId="4" pageNumber="5">ʹ</emphasis> | ||
- pyranyl framework along with the esterified side chain in spirornata A could evidently | ||
<taxonomicName id="4C214D76FFC16E0892AB4C19F9436D19" box="[971,1113,539,558]" form="hydrogen" pageId="4" pageNumber="5" rank="form">form hydrogen</taxonomicName> | ||
bonding interfaces with the aminoacyl residues in the active site of ACE-I, and might form co-ordinate bond with the binding site Zn | ||
<superScript id="7C549BBDFFC16E0895784C4FF9346D6C" attach="left" box="[1048,1070,589,603]" fontSize="6" pageId="4" pageNumber="5">2+</superScript> | ||
ion. Conspicuously greater number of electronegative centers in spirornata A might lead to its greater antihypertensive activity. Also, free radical quenching activities (IC | ||
<subScript id="17A534B0FFC16E0894014C90F8866D97" attach="left" box="[1377,1436,658,672]" fontSize="6" pageId="4" pageNumber="5">50DPPH</subScript> | ||
1.14 and IC | ||
<subScript id="17A534B0FFC16E0892124CAFFEB36D8C" attach="left" box="[882,937,685,699]" fontSize="6" pageId="4" pageNumber="5">50ABTS</subScript> | ||
1.28 mM) exhibited by spirornata A were greater when compared to those exhibited by other analogues (IC | ||
<subScript id="17A534B0FFC16E0894434CCBF82F6DE0" attach="left" box="[1315,1333,713,727]" fontSize="6" pageId="4" pageNumber="5">50</subScript> | ||
1.25–1.71 mM) and commercially available standard (IC | ||
<subScript id="17A534B0FFC16E0895DA4CE7F9D66DC4" attach="left" box="[1210,1228,741,755]" fontSize="6" pageId="4" pageNumber="5">50</subScript> | ||
1.46–1.69 mM). Previoius reports of antioxidant activities of spiroketals ( | ||
<bibRefCitation id="EFB04B04FFC16E08958C4CF8F8DD6C3A" author="Zhuravleva, O. I. & Sobolevskaya, M. P. & Afiyatullov, S. & Kirichuk, N. N. & Denisenko, V. A. & Dmitrenok, P. S. & Yurchenko, E. A. & Dyshlovoy, S. A." box="[1260,1479,762,781]" pageId="4" pageNumber="5" pagination="5930 - 5943" refId="ref13142" refString="Zhuravleva, O. I., Sobolevskaya, M. P., Afiyatullov, S., Kirichuk, N. N., Denisenko, V. A., Dmitrenok, P. S., Yurchenko, E. A., Dyshlovoy, S. A., 2014. Sargassopenillines A-G, 6,6 - spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum. Mar. Drugs 12, 5930 - 5943. https: // doi. org / 10.3390 / md 12125930." type="journal article" year="2014">Zhuravleva et al., 2014</bibRefCitation> | ||
) also corroborated the antioxidant activities of currently isolated spiroketals. | ||
</paragraph> | ||
</subSubSection> | ||
</treatment> | ||
</document> |