Comparison of Pocock and Simon's covariate-adaptive randomization procedures in clinical trials

Overview

This repository hosts the R code developed for the paper "Comparison of Pocock and Simon's covariate-adaptive randomization procedures in clinical trials," submitted for publication.

Randomization Strategies Included

• Pocock & Simon's Minimization
• Hierarchical Dynamic Balancing Randomization
• Complete Randomization
• Stratified Permuted Block Randomization
• Stratified Big Stick Design

Usage

The repository's code can be integrated into clinical trial research, providing a range of randomization methods. For detailed information on each algorithm and examples of usage, refer to the individual script files within the repository.

Acknowledgments

• Original 'Minirand' R package by Man Jin, Adam Polis, and Jonathan Hartzel.
• "Dynamic balancing randomization in controlled clinical trials" by Stephane Heritier, Val Gebski, and Avinesh Pillai.
• "SEQUENTIAL TREATMENT ASSIGNMENT WITH BALANCING FOR PROGNOSTIC FACTORS IN THE CONTROLLED CLINICAL TRIAL" by Stuart J. Pocock and Richard Simon.