The landscape of RNA 3D structure modeling with transformer networks

by Sumit Tarafder, Rahmatullah Roche, Debswapna Bhattacharya

published in Biology Methods and Protocols

RNAmark

RNAmark repository contains the materials related to our large scale study on five transformer based deep learning methods as well as one non deep learning based method for RNA 3D structure prediction:

• DeepFoldRNA
• trRosettaRNA
• DRfold
• RoseTTAFoldNA
• RhoFold
• RNAComposer

The predicted 3D structures of all the methods with and without multiple sequence alignment (MSA) are available target-wise under Predictions. Experimental structures, corresponding fasta sequences, and MSAs used in the analysis are available under Data.

Benchmark set

To evaluate the predictive performance of these methods, we used a newly curated benchmark dataset containing 72 RNA targets (TS72).

• 12 targets were taken from CASP15.
• 60 non-redundant targets were curated from PDB.

Evaluation metrics

We used the following set of assessment metrics as part of our study.

• Template Modeling Score (TM-score) using US-align.
• Local Distance Difference Test (lDDT) calculated via the docker image obtained from OpenStructure registry.
• Interaction Network Fidelity (INF) score evaluated using the casp-rna pipeline available here.
• Clash score from MolProbity package available here.

Evaluation Scripts

• After installation of above tools, change the paths in evaluations.sh in Evaluation folder and run the following command to generate a table of metrics per method. Change the method name in the argument as needed.

cd Evaluation
chmod a+x evaluation.sh
./evaluate.sh DeepFoldRNA

• Table of results will be available in Score.csv file.

Prediction scores per method

• DeepFoldRNA
• trRosettaRNA
• DRfold
• RoseTTAFoldNA
• RhoFold
• RNAComposer

DeepFoldRNA

Targets	TM-score	lDDT	INF	Clash-score
6YMC_A	0.48	0.67	0.34	158.65
7ECM_A	0.27	0.69	0.55	145.08
7EDL_A	0.36	0.68	0.34	192.36
7EDM_A	0.34	0.66	0.43	221.91
7EEM_A	0.45	0.61	0.42	144.23
7EFG_A	0.31	0.55	0.39	147.97
7EQJ_A	0.73	0.64	0.26	175.77
7EXY_A	0.24	0.48	0	138.61
7KUB_A	0.35	0.5	0.22	180.81
7KUC_A	0.49	0.62	0.31	159.92
7KUD_A	0.25	0.43	0	182.27
7KVT_B	0.37	0.4	0.26	181.44
7MLW_F	0.81	0.62	0.3	185.82
7Q48_A	0.13	0.21	0.25	148.25
7Q6L_A	0.14	0.2	0.1	133.9
7Q7X_B	0.26	0.69	0.54	172.28
7Q7X_C	0.24	0.42	0.32	123.06
7QA2_A	0.11	0.21	0.23	250
7QDU_Q	0.19	0.38	0.22	152.34
7QP2_A	0.46	0.66	0.42	144.93
7R6L_A	0.57	0.47	0.28	164.27
7R6L_B	0.17	0.43	0.17	164.61
7R6M_A	0.59	0.48	0.3	165.4
7RQ5_A	0.51	0.68	0.47	240.26
7RWR_A	0.38	0.47	0.29	139.44
7SHX_A	0.22	0.47	0.26	169.01
7UCR_A	0.51	0.64	0.41	140.53
7UGA_A	0.41	0.57	0.36	130.81
7UMC_A	0.32	0.56	0.27	132.82
7UMD_A	0.26	0.55	0.16	158.06
7UME_A	0.3	0.59	0.42	204.26
7UQ6_B	0.63	0.59	0.32	161.23
7UVT_A	0.58	0.49	0.31	197.29
7UZ0_A	0.77	0.63	0.24	155.95
7V06_A	0.45	0.6	0.2	158.87
7V9E_A	0.31	0.46	0.15	186.5
7VFT_A	0.21	0.66	0.45	114.56
7WIA_V	0.4	0.58	0.24	144.42
7XD3_N	0.57	0.47	0.25	180.91
7XJZ_B	0.75	0.61	0.09	189.89
7XK0_B	0.8	0.61	0.13	183.01
7XSN_N	0.58	0.49	0.33	184.93
7YC8_N	0.54	0.46	0.31	176.91
7YGC_N	0.54	0.48	0.3	184.46
8BGU_3	0.67	0.61	0.2	176.79
8D2A_A	0.3	0.55	0.33	193.4
8DMB_W	0.16	0.37	0.22	158.69
8DP3_R	0.3	0.52	0.33	185.15
8E0F_D	0.35	0.72	0.47	118.91
8EG0_C	0.65	0.61	0.3	146.87
8F4O_B	0.58	0.57	0.24	145.62
8FCS_A	0.66	0.66	0.31	163.48
8GXC_A	0.32	0.38	0.15	146.23
8HB8_A	0.22	0.41	0.25	175.3
8HBA_A	0.28	0.38	0.29	181.64
8HBA_B	0.19	0.38	0.29	183.98
8HD6_N	0.57	0.5	0.24	187.21
8I3Z_B	0.12	0.39	0.22	200.4
8I43_A	0.21	0.55	0.26	198.02
8I7N_N	0.57	0.47	0.24	186.68
R1107	0.48	0.53	0.23	162.62
R1108	0.48	0.56	0.35	152.25
R1116	0.38	0.53	0.24	184.94
R1117	0.21	0.43	0.18	196.54
R1126	0.18	0.37	0.21	154.74
R1128	0.36	0.61	0.32	162.87
R1136	0.14	0.28	0.27	131.86
R1138	0.12	0.36	0.28	140.9
R1149	0.28	0.53	0.12	164.71
R1156	0.29	0.53	0.28	165.26
R1189	0.23	0.46	0.27	148.38
R1190	0.25	0.5	0.25	148.38
Mean	0.39	0.52	0.28	167.08

trRosettaRNA

Targets	TM-score	lDDT	INF	Clash-score
6YMC_A	0.4	0.8	0.89	5.98
7ECM_A	0.24	0.7	0.76	2.57
7EDL_A	0.34	0.75	0.88	9.87
7EDM_A	0.29	0.75	0.88	2.82
7EEM_A	0.54	0.8	0.85	16.67
7EFG_A	0.44	0.77	0.96	17.57
7EQJ_A	0.67	0.75	0.79	28.23
7EXY_A	0.17	0.27	0.57	0
7KUB_A	0.35	0.55	0.76	14.53
7KUC_A	0.48	0.77	0.93	1.91
7KUD_A	0.38	0.44	0.74	0
7KVT_B	0.23	0.38	0.56	69.78
7MLW_F	0.53	0.6	0.67	35.17
7Q48_A	0.12	0.22	0.43	1.39
7Q6L_A	0.11	0.27	0.32	9.72
7Q7X_B	0.31	0.74	0.93	2.6
7Q7X_C	0.26	0.45	0.75	0
7QA2_A	0.11	0.23	0.38	0
7QDU_Q	0.17	0.37	0.64	42.67
7QP2_A	0.64	0.85	0.94	15.48
7R6L_A	0.39	0.44	0.62	43.53
7R6L_B	0.21	0.47	0.61	0
7R6M_A	0.33	0.43	0.65	31.77
7RQ5_A	0.35	0.67	0.81	8.1
7RWR_A	0.38	0.58	0.82	13.92
7SHX_A	0.2	0.52	0.6	27.28
7UCR_A	0.62	0.82	0.84	36.61
7UGA_A	0.36	0.7	0.84	22.43
7UMC_A	0.34	0.59	0.68	40.37
7UMD_A	0.21	0.56	0.73	28.64
7UME_A	0.43	0.68	0.85	14.38
7UQ6_B	0.65	0.72	0.7	40.56
7UVT_A	0.25	0.47	0.67	25.63
7UZ0_A	0.74	0.76	0.75	58.76
7V06_A	0.38	0.63	0.83	17.52
7V9E_A	0.27	0.5	0.63	48.26
7VFT_A	0.2	0.74	0.93	0
7WIA_V	0.36	0.71	0.8	20.89
7XD3_N	0.21	0.41	0.55	43.09
7XJZ_B	0.7	0.75	0.78	39.05
7XK0_B	0.78	0.75	0.64	41.91
7XSN_N	0.25	0.44	0.64	40.59
7YC8_N	0.28	0.44	0.65	31.75
7YGC_N	0.34	0.45	0.62	33.73
8BGU_3	0.63	0.71	0.73	51.52
8D2A_A	0.33	0.76	0.83	25.3
8DMB_W	0.16	0.43	0.63	17.56
8DP3_R	0.28	0.57	0.71	60.85
8E0F_D	0.28	0.84	0.67	23.37
8EG0_C	0.58	0.71	0.79	19.61
8F4O_B	0.54	0.64	0.64	81.24
8FCS_A	0.52	0.77	0.83	17.54
8GXC_A	0.27	0.35	0.53	19.18
8HB8_A	0.23	0.37	0.51	34.21
8HBA_A	0.22	0.37	0.53	38.49
8HBA_B	0.24	0.37	0.48	36.4
8HD6_N	0.23	0.43	0.61	31.91
8I3Z_B	0.13	0.35	0.57	5.96
8I43_A	0.19	0.65	0.67	18.12
8I7N_N	0.21	0.41	0.58	45.56
R1107	0.26	0.51	0.69	46.15
R1108	0.43	0.67	0.67	68.29
R1116	0.56	0.62	0.66	31.8
R1117	0.35	0.51	0.52	15.12
R1126	0.22	0.49	0.7	62.36
R1128	0.31	0.66	0.75	82.37
R1136	0.24	0.5	0.77	5.24
R1138	0.12	0.34	0.59	21.32
R1149	0.26	0.48	0.6	43.14
R1156	0.25	0.55	0.7	19.4
R1189	0.21	0.49	0.56	34.22
R1190	0.22	0.52	0.62	29.78
Mean	0.34	0.57	0.69	27.39

DRfold

Targets	TM-score	lDDT	INF	Clash-score
6YMC_A	0.56	0.86	0.93	19.12
7ECM_A	0.24	0.7	0.82	120.51
7EDL_A	0.39	0.87	0.97	11.25
7EDM_A	0.31	0.84	0.86	4.23
7EEM_A	0.52	0.83	0.83	93.94
7EFG_A	0.33	0.74	0.8	123.99
7EQJ_A	0.67	0.79	0.83	103.65
7EXY_A	0.25	0.58	0.81	63.24
7KUB_A	0.42	0.73	0.87	74.88
7KUC_A	0.51	0.78	0.9	47.71
7KUD_A	0.43	0.73	0.9	66.67
7KVT_B	0.38	0.5	0.59	251.26
7MLW_F	0.47	0.56	0.68	167.91
7Q48_A	0.13	0.23	0.41	115.76
7Q6L_A	0.14	0.24	0.36	41.61
7Q7X_B	0.23	0.77	0.87	48.3
7Q7X_C	0.2	0.5	0.7	65.81
7QA2_A	0.18	0.24	0.36	78.62
7QDU_Q	0.1	0.27	0.1	119.09
7QP2_A	0.61	0.9	0.88	83.14
7R6L_A	0.25	0.31	0.25	360.32
7R6L_B	0.15	0.56	0.6	181.19
7R6M_A	0.24	0.29	0.25	365.68
7RQ5_A	0.29	0.47	0.76	53.48
7RWR_A	0.43	0.57	0.77	213.58
7SHX_A	0.26	0.55	0.7	197.34
7UCR_A	0.63	0.87	0.84	96
7UGA_A	0.36	0.73	0.8	128.75
7UMC_A	0.48	0.68	0.86	89.98
7UMD_A	0.28	0.62	0.78	128.12
7UME_A	0.39	0.72	0.81	74.61
7UQ6_B	0.62	0.76	0.75	152.54
7UVT_A	0.32	0.34	0.32	389.35
7UZ0_A	0.56	0.66	0.7	122.15
7V06_A	0.44	0.75	0.81	81.62
7V9E_A	0.28	0.61	0.81	178.07
7VFT_A	0.22	0.7	0.68	79.73
7WIA_V	0.42	0.71	0.84	72.15
7XD3_N	0.26	0.3	0.29	347.05
7XJZ_B	0.74	0.76	0.77	67.07
7XK0_B	0.79	0.76	0.75	63.56
7XSN_N	0.31	0.34	0.39	400.67
7YC8_N	0.33	0.29	0.4	466.11
7YGC_N	0.3	0.35	0.39	433.38
8BGU_3	0.67	0.8	0.86	90.3
8D2A_A	0.29	0.69	0.84	102.25
8DMB_W	0.19	0.37	0.32	415.37
8DP3_R	0.31	0.68	0.81	172.06
8E0F_D	0.33	0.9	0.89	17.51
8EG0_C	0.63	0.75	0.86	91.61
8F4O_B	0.59	0.71	0.84	87.35
8FCS_A	0.71	0.81	0.88	76.82
8GXC_A	0.22	0.34	0.43	306.88
8HB8_A	0.24	0.38	0.42	292.22
8HBA_A	0.18	0.35	0.47	285.43
8HBA_B	0.2	0.36	0.5	280.43
8HD6_N	0.25	0.3	0.27	363.67
8I3Z_B	0.14	0.39	0.61	94.43
8I43_A	0.22	0.73	0.78	49.34
8I7N_N	0.27	0.31	0.26	323.8
R1107	0.24	0.41	0.61	135.59
R1108	0.37	0.65	0.79	165.08
R1116	0.46	0.61	0.79	209.02
R1117	0.25	0.58	0.65	195.02
R1126	0.14	0.41	0.36	525.35
R1128	0.28	0.7	0.8	249.9
R1136	0.17	0.37	0.32	414.27
R1138	0.09	0.27	0.02	66.67
R1149	0.31	0.65	0.79	164.21
R1156	0.29	0.48	0.56	286.65
R1189	0.22	0.47	0.57	355.28
R1190	0.24	0.52	0.56	355.28
Mean	0.35	0.57	0.65	175.21

RoseTTAFoldNA

Targets	TM-score	lDDT	INF	Clash-score
6YMC_A	0.59	0.94	0.96	9.56
7ECM_A	0.38	0.85	0.95	0
7EDL_A	0.39	0.88	0.97	7.03
7EDM_A	0.34	0.83	0.91	9.86
7EEM_A	0.49	0.9	0.94	8.32
7EFG_A	0.2	0.71	0.65	191.39
7EQJ_A	0.76	0.82	0.9	22.06
7EXY_A	0.22	0.54	0.84	31.5
7KUB_A	0.42	0.59	0.79	27.45
7KUC_A	0.44	0.81	0.88	113.03
7KUD_A	0.28	0.7	0.86	94.79
7KVT_B	0.26	0.43	0.58	64.77
7MLW_F	0.81	0.76	0.81	50.98
7Q48_A	0.13	0.28	0.36	69.93
7Q6L_A	0.16	0.24	0.35	24.9
7Q7X_B	0.19	0.75	0.93	15.56
7Q7X_C	0.19	0.45	0.75	6.43
7QA2_A	0.11	0.28	0.32	93.92
7QDU_Q	0.14	0.27	0.57	49.55
7QP2_A	0.55	0.93	0.94	9.5
7R6L_A	0.56	0.58	0.78	44.93
7R6L_B	0.12	0.44	0.58	35.42
7R6M_A	0.55	0.53	0.75	58.37
7RQ5_A	0.32	0.67	0.77	66.13
7RWR_A	0.37	0.53	0.79	58.24
7SHX_A	0.24	0.58	0.76	66.34
7UCR_A	0.62	0.93	0.96	8
7UGA_A	0.36	0.67	0.78	70.71
7UMC_A	0.53	0.7	0.86	59.14
7UMD_A	0.25	0.58	0.83	32.56
7UME_A	0.32	0.72	0.85	111.36
7UQ6_B	0.69	0.83	0.83	44.26
7UVT_A	0.47	0.56	0.75	44.98
7UZ0_A	0.73	0.81	0.84	30.26
7V06_A	0.31	0.67	0.85	48.83
7V9E_A	0.3	0.53	0.75	71.76
7VFT_A	0.17	0.78	0.68	25.37
7WIA_V	0.36	0.68	0.79	52.5
7XD3_N	0.48	0.52	0.7	50.29
7XJZ_B	0.73	0.81	0.86	25.15
7XK0_B	0.78	0.82	0.86	28.07
7XSN_N	0.5	0.53	0.77	48.46
7YC8_N	0.54	0.55	0.77	47.49
7YGC_N	0.57	0.56	0.75	46.19
8BGU_3	0.64	0.76	0.88	36.79
8D2A_A	0.4	0.84	0.92	46.9
8DMB_W	0.2	0.42	0.7	47.94
8DP3_R	0.34	0.62	0.82	41.84
8E0F_D	0.24	0.77	0.87	9.72
8EG0_C	0.61	0.75	0.91	31.46
8F4O_B	0.59	0.74	0.89	29.86
8FCS_A	0.6	0.81	0.89	31.11
8GXC_A	0.37	0.4	0.6	29.53
8HB8_A	0.21	0.32	0.52	66
8HBA_A	0.24	0.3	0.55	34.57
8HBA_B	0.24	0.31	0.59	43.69
8HD6_N	0.51	0.54	0.72	68.33
8I3Z_B	0.15	0.35	0.42	49.7
8I43_A	0.24	0.73	0.85	54.55
8I7N_N	0.48	0.54	0.71	61.28
R1107	0.34	0.65	0.84	35.65
R1108	0.33	0.68	0.86	40.2
R1116	0.44	0.61	0.8	48.34
R1117	0.19	0.32	0.6	59.2
R1126	0.23	0.48	0.71	34.25
R1128	0.28	0.65	0.8	42.87
R1136	0.19	0.5	0.76	47.45
R1138	0.15	0.26	0.59	51.67
R1149	0.26	0.53	0.72	62.31
R1156	0.3	0.63	0.8	41.77
R1189	0.22	0.54	0.73	43.51
R1190	0.25	0.57	0.72	37.55
Mean	0.38	0.61	0.76	45.88

RhoFold

Targets	TM-score	lDDT	INF	Clash-score
6YMC_A	0.49	0.8	0.96	442
7ECM_A	0.31	0.69	0.79	466.84
7EDL_A	0.34	0.79	0.94	505.08
7EDM_A	0.31	0.8	0.91	431.46
7EEM_A	0.56	0.81	0.93	507.92
7EFG_A	0.31	0.74	0.92	479.81
7EQJ_A	0.76	0.78	0.9	435.57
7EXY_A	0.23	0.55	0.85	478.87
7KUB_A	0.33	0.55	0.72	565.03
7KUC_A	0.35	0.73	0.87	524.27
7KUD_A	0.31	0.72	0.75	447.37
7KVT_B	0.68	0.66	0.72	495.11
7MLW_F	0.82	0.7	0.77	454.69
7Q48_A	0.11	0.22	0.42	465.44
7Q6L_A	0.11	0.23	0.34	461.1
7Q7X_B	0.24	0.75	1	514.02
7Q7X_C	0.32	0.6	0.88	565.5
7QA2_A	0.13	0.23	0.38	506.28
7QDU_Q	0.06	0.29	0.02	65.59
7QP2_A	0.68	0.84	0.92	519.46
7R6L_A	0.46	0.46	0.72	777.45
7R6L_B	0.14	0.42	0.54	562.41
7R6M_A	0.4	0.43	0.67	730.32
7RQ5_A	0.27	0.44	0.76	503.28
7RWR_A	0.38	0.51	0.8	467.84
7SHX_A	0.19	0.47	0.68	477.43
7UCR_A	0.74	0.85	0.92	507.6
7UGA_A	0.42	0.64	0.8	571.85
7UMC_A	0.37	0.66	0.83	419.65
7UMD_A	0.3	0.57	0.8	473.06
7UME_A	0.33	0.66	0.88	425.17
7UQ6_B	0.62	0.74	0.8	479.02
7UVT_A	0.42	0.48	0.74	624.84
7UZ0_A	0.73	0.77	0.88	486.44
7V06_A	0.35	0.66	0.8	454.48
7V9E_A	0.62	0.71	0.86	449.9
7VFT_A	0.19	0.71	0.75	504.8
7WIA_V	0.35	0.63	0.81	455.19
7XD3_N	0.43	0.45	0.68	669.36
7XJZ_B	0.78	0.73	0.83	446.84
7XK0_B	0.81	0.74	0.82	440.24
7XSN_N	0.44	0.48	0.75	631.33
7YC8_N	0.42	0.46	0.7	738.82
7YGC_N	0.41	0.46	0.69	762.75
8BGU_3	0.64	0.7	0.84	504.55
8D2A_A	0.28	0.66	0.83	433.82
8DMB_W	0.31	0.43	0.69	608.81
8DP3_R	0.31	0.61	0.83	389.85
8E0F_D	0.32	0.82	0.95	440.32
8EG0_C	0.67	0.72	0.86	434.78
8F4O_B	0.55	0.66	0.8	465.75
8FCS_A	0.69	0.74	0.88	401.72
8GXC_A	0.22	0.4	0.45	716.79
8HB8_A	0.23	0.4	0.51	595.38
8HBA_A	0.29	0.4	0.52	592.47
8HBA_B	0.3	0.4	0.54	593.77
8HD6_N	0.44	0.46	0.69	627.91
8I3Z_B	0.15	0.34	0.55	703.11
8I43_A	0.11	0.66	0.72	461.93
8I7N_N	0.44	0.44	0.67	637.06
R1107	0.37	0.5	0.68	566.14
R1108	0.44	0.66	0.87	476.1
R1116	0.53	0.62	0.8	444.77
R1117	0.25	0.53	0.69	509.39
R1126	0.07	0.32	0.03	41.83
R1128	0.34	0.6	0.74	531.13
R1136	0.07	0.29	0.04	139.17
R1138	0.05	0.26	0.02	123.8
R1149	0.33	0.57	0.84	532.1
R1156	0.34	0.61	0.82	499.04
R1189	0.19	0.5	0.63	509.37
R1190	0.23	0.55	0.64	509.37
Mean	0.38	0.58	0.72	498.36

RNAComposer

Targets	TM-score	lDDT	INF	Clash-score
6YMC_A	0.38	0.82	0.92	23.95
7ECM_A	0.17	0.56	0.53	12.89
7EDL_A	0.18	0.58	0.44	13.55
7EDM_A	0.11	0.66	0.71	20.35
7EEM_A	0.28	0.55	0.7	20.62
7EFG_A	0.17	0.46	0.47	17.6
7EQJ_A	0.23	0.29	0.47	21.29
7EXY_A	0.15	0.51	0.76	7.91
7KUB_A	0.39	0.62	0.83	16.1
7KUC_A	0.33	0.69	0.83	15.3
7KUD_A	0.2	0.66	0.89	7.18
7KVT_B	0.22	0.33	0.43	20.6
7MLW_F	0.37	0.54	0.39	12.59
7Q48_A	0.12	0.21	0.49	16.76
7Q6L_A	0.03	0.22	0.4	19.47
7Q7X_B	0.09	0.67	0.79	18.21
7Q7X_C	0.21	0.52	0.62	11.6
7QA2_A	0.07	0.2	0.44	16.57
7QP2_A	0.25	0.57	0.61	20.62
7R6L_A	0.14	0.35	0.4	18.05
7R6L_B	0.1	0.5	0.53	27.14
7R6M_A	0.21	0.35	0.47	68.71
7RQ5_A	0.22	0.63	0.76	17.86
7RWR_A	0.3	0.51	0.74	19.67
7SHX_A	0.2	0.5	0.66	18.74
7UCR_A	0.26	0.56	0.72	20.62
7UGA_A	0.32	0.53	0.71	15.21
7UMC_A	0.22	0.61	0.85	15.53
7UMD_A	0.23	0.61	0.81	18.59
7UME_A	0.29	0.65	0.88	17.72
7UQ6_B	0.2	0.5	0.3	20.58
7UVT_A	0.2	0.42	0.38	57.23
7UZ0_A	0.2	0.44	0.32	22.44
7V06_A	0.29	0.6	0.78	18.99
7V9E_A	0.25	0.54	0.72	18.29
7VFT_A	0.17	0.67	0.62	14.71
7WIA_V	0.43	0.72	0.51	17.36
7XD3_N	0.23	0.42	0.63	58.66
7XJZ_B	0.23	0.47	0.32	24.46
7XK0_B	0.24	0.47	0.31	24.46
7XSN_N	0.18	0.42	0.7	20.13
7YC8_N	0.14	0.4	0.38	18.05
7YGC_N	0.14	0.41	0.69	18.05
8BGU_3	0.52	0.6	0.79	12.63
8D2A_A	0.27	0.62	0.74	15.01
8DMB_W	0.13	0.33	0.42	20.34
8DP3_R	0.28	0.59	0.87	21.91
8E0F_D	0.14	0.57	0.5	12.67
8EG0_C	0.21	0.48	0.47	23.84
8F4O_B	0.17	0.32	0.39	14.98
8FCS_A	0.51	0.73	0.85	17.11
8GXC_A	0.12	0.22	0.47	20.9
8HB8_A	0.18	0.26	0.48	15.15
8HBA_A	0.15	0.27	0.33	16
8HBA_B	0.16	0.26	0.39	16
8HD6_N	0.21	0.43	0.65	34.44
8I3Z_B	0.13	0.33	0.4	14.93
8I43_A	0.16	0.6	0.68	21.45
8I7N_N	0.22	0.41	0.68	47.2
R1107	0.22	0.36	0.6	19.47
R1108	0.3	0.47	0.73	9.5
R1116	0.43	0.65	0.34	15.3
R1117	0.12	0.2	0.55	24.86
R1126	0.18	0.5	0.79	157.12
R1128	0.23	0.69	0.87	12.63
R1136	0.2	0.49	0.77	52.37
R1149	0.31	0.61	0.83	16.15
R1156	0.18	0.44	0.67	27.26
R1189	0.2	0.49	0.68	11.24
R1190	0.24	0.54	0.69	11.24
Mean	0.22	0.49	0.61	22.66