Sample of how to set up multidex using support library and binding project for Android pre lollipop
To use compile and reference the AndroidMultiDex library. This project creates a binding for the Android MultiDex Support Library.
After the project has been referenced modify the applicaiton's manifest to add the android:name attribute to derive your application from the Android MultiDex Support Library. For example:
<?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android" package="AndroidMultiDexTest.AndroidMultiDexTest" android:versionCode="1" android:versionName="1.0">
<uses-sdk android:minSdkVersion="16" />
<application android:label="AndroidMultiDexTest"
android:name="android.support.multidex.MultiDexApplication">
</application>
</manifest>