argument to easily switch off variability

[AndreasCalvagone]

It would be nice to have an argument to simulate() that allows to switch of all variability in the simulations for a quick generation of typical value simulations.

[luyckxn]

Current way for simulating typical profiles:

• Use a CAMPSIS dataset with a single subject (see also Dataset: update the number of subjects easily #27)
• Disable variabilities in the model using the disable() method

[luyckxn]

In this ticket, we propose to add a new argument to the simulate method, e.g. novar=TRUE.

This would be a nice to have feature. However the implementation is not that simple (i.e. how to deal with random covariates in the dataset: take mean, median, first value, etc. ).

[luyckxn]

After some consideration, I would be more in favour of implementing this in the settings in an object oriented fashion.

E.g. TypicalProfile() implements/extends SimulationModeSettings()

and the concept can be extended (further modes can be added, etc.)