Modeling of published clinical 5-fluorouracil (5-FU) and uracil studies for model evaluation
Within this repository, we distribute whole-body parent-metabolite PBPK models for 5-FU and uracil, as well as their metabolites 5,6-dihydrofluorouracil and 5,6-dihydrouracil. The models were developed and evaluated using published clinical studies. The files contain 5-FU administrations as bolus injectsion and infusions as well as 5-FU and uracil administrations as oral solutions. Moreover, diurnal variations were simulated for constant rate and chronomodulated infusions. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation, please refer to [1].
PK-Sim Version 9.1.