Canonical correlation analysis identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic mild cognitive impairment

Use of Canonical Correlation Analysis to identify a shared neurophysiological marker of vagal control from electrocardiogram (during auditory working memory) and functional connectivity (FC) data.

Complete Data CCA.xlsx contains the data of two datasets: CogTe (divided in SampleO and SampleR) and ESB (divided in Nback and Stroop).

• Sheet 1: SampleO with RMSSD, FCs (between and within), PICs (internal and external), and demographic information
• Sheet 2: SampleR with RMSSD, PICs (internal and external), and demographic information
• Sheet 3: SampleV Nback with RMSSD, PICs (internal and external), and demographic information
• Sheet 4: SampleV Stroop with RMSSD, PICs (internal and external), and demographic information

CCA_code.R is the R code used to calculate CCA and do linear regression with the canonical variates and internal or external PIC.