CompARE (https://www.grbio.eu/compare/) is a initiative inspired to provide help on issues relating to trials with composite endpoints. CompARE may be used as a tool for calculating the elements needed in the planning phase of clinical trials involving composite endpoints. CompARE comprises two diferent tools:
- A couple of shiny apps for time-to-event and binary endpoints, respectively. You can found more info here
- The R package CompAREdesign
The CompAREdesign package contains the following functions:
- surv_tte to compute the survival function for the composite time-to-event endpoint and both components
- effectsize_tte to compute the treatment effect for the composite time-to-event endpoint
- samplesize_tte to compute the sample size for the composite time-to-event endpoint
- ARE_tte to compute the ARE method for time-to-event endpoints
- plot_tte to get four plots related to previous features
- simula_tte to simulate time-to-event data for the time-to-event composite endpoint and its components
- prob_cbe to compute the probability of a composite binary endpoint
- lower_corr to compute the lower bound of Pearson’s correlation
- upper_corr to compute the upper bound for Pearson’s correlation
- effectsize_cbe to compute the treatment effect on the composite binary endpoint
- samplesize_cbe to compute the sample size for composite binary endpoint
- ARE_cbe to compute the ARE method for composite binary endpoint
- simula_cbe to simulate time-to-event data for the binary composite endpoint and its components
install.packages("CompAREdesign")
library("CompAREdesign")