Analyses for multi-unit spiking responses & evoked local field potentials (LFP) obtained in response to mechanical stimulation of the forelimb digits ("Solenoid"), intracortical microstimulation (ICMS), or Solenoid+ICMS stimuli from the anesthetized rat.
- Start with
main.m - Organization of objects is hierarchical:
solBlockis "child" tosolRatsolChannelis "child" tosolBlock- Constructor for
solRatautomatically generates all subordinatesolBlockandsolChannelobjects, so the main access-point in general for batch analysis issolRat, while methods atsolBlocklevel are more for trouble-shooting and testing or development.
- Once all
solRatobjects are constructed, they can be saved using the overloadedsavemethod ofsolRat. - Once batch figures are exported (also requires connection to KUMC Isilon Processed_Data drives), the exported figures can be viewed using the
figBrowserclass, which is primarily convenient if you need to re-export higher resolution versions of existing figures.
- Determine if there is usable data to test the following generic hypothesis:
- ICMS induces functional changes in somatosensory evoked potentials.
- To test this hypothesis, we should examine these sub-hypotheses:
- ICMS induces a statistically significant change in duration between first evoked multi-unit spike peak and cutaneous stimulus offset, compared to responses during cutaneous stimulation only.
- ICMS induces a statistically significant change in magnitude of average evoked LFP response when paired with cutaneous stimuli.
- To bring these hypotheses into clinical relevance, we should test the following hypotheses:
- ICMS in RFA (which is where most of the stimuli were targeted) alters evoked responses (spiking, LFP, or linear/nonlinear metrics of information transfer between the two areas in response to cutaneous stimulus) in FL-S1.