Vascular endothelial cells (ECs) modulate smooth muscle cells (SMC) contractility, assisting in vascular tone and regulation. Our lab has created a detailed model for this cell that integrates plasma membrane electrophysiology and calcium dynamics to investigate EC responses to various stimuli. It also expands on previous formulations by including more detailed transmembrane current descriptions.
To assist in disseminating our model to as many people working in our field as possible we have designed an interactive graphical user interface (GUI) that allows for a user to investigate various phenomena relating to EC behavior without having to understand the complicated coding or math formulations behind them.
Further information on our modeling efforts can be found at: https://tsoukias.fiu.edu/
Original Endothelial Cell Model by Haroldo Silva:
A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells Haroldo S. Silva, Adam Kapela, and Nikolaos M. Tsoukias American Journal of Physiology-Cell Physiology 2007 293:1, C277-C293
HOW TO INSTALL:
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Install via mlapp file
a. Download EndoCellModel.mlappinstall
b. Open using MATLAB 2016a or greater
c. App should install easily and be accesible in the apps panel along the main MATLAB bar.
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Install via external executable
a. Download EndoCellInstaller.exe
b. Right click and select "Run as Administrator"
c. You will be prompted to install the application, accept. ci. If you do not have MATLAB Runtime Component installed it will be downloaded for you (~700 MBs)
d. The Endothelial Cell app icon should appear on your desktop and can be run from there easily.