ChemoImmunoSyng

Code repository for chemoimmunotherapy synergism project

1. Source code

signature_training.py3: Implementation of R and S signature identification procedure.

Shift_ability_calculation.py3: Implementation of shift ability score calculation on post-treatment transcriptomes using identified R and S signatures.

2. Data

X_training.csv: Training data (X) that can be directly used as input of signature_training.py3

Y_training.csv: Training data (y) that can be directly used as input of signature_training.py3

X_validation.csv: Validation set that can be used as validation input in signature_training.py3

Y_validation.csv: Validation set that can be used as validation input in signature_training.py3

3. Core signature

Contains the .gmt file of R and S signature established and used in this study.

4. Annotation

The annotation file of L1000 landmark genes and best inferred genes (BINGs).