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iviNSCLC is an R package that runs the Innovation and Value Initiative's (IVI's) non-small cell lung cancer (NSCLC) simulation model (the IVI-NSCLC model). The model simulates the costs, health outcomes, and risks associated with sequences of treatment including EGFR Tyrosine Kinase Inhibitors (TKIs), platinum-based doublet chemotherapy (PBDC), anti–vascular endothelial growth factor (anti-VEGF) therapy, and immune checkpoint inhibitors for patients with epidermal growth factor receptor (EGFR) positive NSCLC.


# Install the development version from GitHub:
# install.packages("devtools")

File structure

The components of the package iviNSCLC are distributed in eight directories:

  1. R: contains all R related code for simulating disease progression, costs, and QALYs. The code relies heavily on the hesim package.
  2. data-raw: Contains R scripts to generate tables used in the package which are saved into data. The input used in the NMA are included in the subdrectory mstate-nma-data. The output of the NMA is stored in the subdirectory mstate-nma.
  3. data: Contains tables created by the R scripts in data-raw. These are the parameter estimates that load with the package and can be viewed with data(package = "iviNSCLC").
  4. docs: Articles, references, and author information are stored here.
  5. man: Manual and general documentation.
  6. pkgdown: The package website.
  7. tests: Unit tests for the package.
  8. vignettes: Files for the package tutorial.


The IVI-NSCLC simulation model




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