PKPDmodels

This repository contains definitions of PK/PD models used in the InsightRX platform.

These models can be installed as R packages using the PKPDsim package:

library("PKPDsim")
model_from_api("models/pk_vanco_anderson.json5", to_package = TRUE, install_all = TRUE)

Please note that these models may differ from those used in production by InsightRX. They are provided for demonstration purposes only, and should not be used for dosing patients.

Example usage

To simulate PK, provide the model and parameters to PKPDsim::sim() along with a dosing regimen and covariates.

library("PKPDsim")

## Create dosing regimen and covariates
reg <- new_regimen(
  amt = 100,
  n = 3,
  interval = 12,
  type = "infusion",
  t_inf = 1
)

covs <- list(
  WT = new_covariate(4),
  PMA = new_covariate(42),
  CR = new_covariate(0.5),
  CL_HEMO = new_covariate(0)
)

## Perform simulation
sim(
  ode = pkvancoanderson::model(),
  parameters = pkvancoanderson::parameters(),
  regimen = reg,
  covariates = covs
)

See PKPDsim documentation for more details about how to set up model simulations.