Dysregulated STAT3 signaling and T cell immunometabolic dysfunction
define a targetable, high mortality subphenotype of critically ill children
Sepsis is the leading cause of death of hospitalized children worldwide.
Despite the established link between immune dysregulation and mortality in pediatric sepsis, it remains unclear which host immune factors contribute causally to adverse sepsis outcomes. Identifying modifiable pathobiology is an essential first step to successful translation of biologic insights into precision therapeutics.
We designed a prospective, longitudinal cohort study of 88 critically ill pediatric patients with multiple organ dysfunction syndrome (MODS), including patients with and without sepsis, to define subphenotypes associated with targetable mechanisms of immune dysregulation.
