varGWASR

R package to perform the regression Brown-Forsythe test to estimate SNP-variance effects. GWAS software also available from varGWAS

Install

if(!require("remotes"))
   install.packages("remotes")
remotes::install_github("mrcieu/varGWASR")

Example

Example is available from https://mrcieu.github.io/varGWASR/inst/doc/Simulation.html

Citation

Lyon M, Millard L, Davey Smith G, Gaunt T, Tilling K. Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation. MedRxiv (2022). https://doi.org/10.1101/2022.01.05.21268406

GWAS

GWAS software also available from https://github.com/MRCIEU/varGWAS