Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
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<html><pre> This is the readme for the model from the paper Markaki M, Orphanoudakis S, Poirazi P (2005) Modelling reduced excitability in aged CA1 neurons as a calcium-dependent process Neurocomputing 65-66:305-314 These model files were supplied by Dr Poirazi. The model files were changed slightly after the paper however they reproduce the traces in Figure 3. Usage ----- Auto-launch from ModelDB or download and extract the archive and then unix/linux ---------- Compile the mod files with "nrnivmodl mechanism" , then start with "nrngui mosinit.hoc" mswin ----- Compile the mod files with mknrndll. Move the nrnmech.dll up one level to the top level directory. Double click on mosinit.hoc in a windows explorer. Once the simulation has started press the run button to generate figures similar to the traces in Figure 2 (increased Ca2+): <img src="./screenshot1.jpg" alt="screenshot1"> <img src="./screenshot2.jpg" alt="screenshot2"> <img src="./screenshot3.jpg" alt="screenshot3"> 20120201 cadL.mod cad.mod cadN.mod updated to derivimplicit as per http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592 </pre></html>
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Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
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