GitHub - ModelDBRepository/128446: Short term plasticity at the cerebellar granule cell (Nieus et al. 2006)

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Name		Name	Last commit message	Last commit date
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Ampa.mod		Ampa.mod
Figure7_of_Nieus2006_Demo.hoc		Figure7_of_Nieus2006_Demo.hoc
Nmda.mod		Nmda.mod
init.ses		init.ses
mosinit.hoc		mosinit.hoc
pregen2.mod		pregen2.mod
readme.html		readme.html
screenshot.jpg		screenshot.jpg

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The files refer to the model published in the paper:

"LTP regulates burst initiation and frequency at mossy fiber-granule
cell synapses of rat cerebellum: experimental observations and
theoretical predictions." Nieus T, Sola E, Mapelli J, Saftenku E,
Rossi P, D'Angelo E.  J Neurophysiol. 2006 Feb;95(2):686-99"

These files were contributed by Thierry Nieus.

The scripts reproduce Figure 7 of the paper. The control condition,
release probability (U) = 0.416, is set by default. To reproduce the
right panel of the figure set release probability, the variable ''MF
to GRC synapse Prel'', equal to 0.6.

To run:
-------
Either auto-launch from ModelDB (after NEURON, available from
http://www.neuron.yale.edu, is installed) or
1) download and extract the files.
2) Compile the mod files as usual on your platform (run mknrndll under
windows, execute nrnivmodl in the extracted directory under linux, or
drag and drop the extracted folder onto the mknrndll icon under mac os
x).
3) Then start mosinit.hoc (double click on mosinit.hoc in windows,
type "nrngui mosinit.hoc" in linux, or drag and drop the mosinit.hoc
file onto the nrngui icon in mac os x).

Once the simulation is running press the Init & Run button.  The
following panels relevant to the left panel of Figure 7 will be
generated:

<img src="./screenshot.jpg" alt="screenshot">
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