GitHub - ModelDBRepository/144520: Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

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Name		Name	Last commit message	Last commit date
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Unit.inc		Unit.inc
Volume.inc		Volume.inc
cadynam.mod		cadynam.mod
cellinit.hoc		cellinit.hoc
fig6.hoc		fig6.hoc
fig6.jpg		fig6.jpg
fig6.ses		fig6.ses
ibg.mod		ibg.mod
if.mod		if.mod
ik1.mod		ik1.mod
ikd.mod		ikd.mod
inaca.mod		inaca.mod
inaf.mod		inaf.mod
inak.mod		inak.mod
init.ses		init.ses
isi.mod		isi.mod
ito.mod		ito.mod
kcum.mod		kcum.mod
mosinit.hoc		mosinit.hoc
nacum.mod		nacum.mod
readme.html		readme.html

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<html><pre>
This model reproduces the cardiac action potentials and pacemaker
activity of a mammalian cell of the sinoatrial node.

It is based on the paper by :

DiFrancesco D & Noble D (1985) A model of cardiac electrical activity
incorporating ionic pumps and concentration changes.
Phil. Trans. R. Soc. Lond. B 307:353-398
[<a href="http://www.ncbi.nlm.nih.gov/pubmed/2578676" target='url'
>PubMed</a>]

implemented and modified for Neuron by Francois E. Gannier
	from University of Tours - FRANCE
	Physiologie des Cellules Cardiaques et Vasculaires
	email address: francois.gannier@univ-tours.fr

It was the first model to incorporate the external and internal
concentration changes and has been very influential in directing
modeling efforts.

To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:

unix/linux:
-----------
type nrnivmodl in the DiFrancescoNoble1985 folder and then
nrngui mosinit.hoc

mswin:
------
run mknrndll and then double click on mosinit.hoc

MAC OS X:
--------
Drag and drop the DiFrancescoNoble1985 folder onto the mknrndll icon.  
Drag and drop the mosinit.hoc file onto the nrngui icon.

Once the simulation starts it recreates the Fig. 6 of the original
paper:

<img src="./fig6.jpg"" alt="Figure 6">
</pre></html>