GitHub - ModelDBRepository/155602: Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)

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Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)

modeldb.science/155602

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Name		Name	Last commit message	Last commit date
Latest commit History 4 Commits
CaBK.mod		CaBK.mod
Gfluct2.mod		Gfluct2.mod
LcaMig.mod		LcaMig.mod
ReadMe.html		ReadMe.html
bgka.mod		bgka.mod
ccanl.mod		ccanl.mod
fixed rseed Control -74 spill_ tonic 10uS with mossy kill.hoc		fixed rseed Control -74 spill_ tonic 10uS with mossy kill.hoc
fixed rseed Pilo -54 spill_ tonic 10uS with mossy kill.hoc		fixed rseed Pilo -54 spill_ tonic 10uS with mossy kill.hoc
gap.mod		gap.mod
gskch.mod		gskch.mod
hyperde3.mod		hyperde3.mod
ichan2.mod		ichan2.mod
markov.mod		markov.mod
mosinit.hoc		mosinit.hoc
nca.mod		nca.mod
screenshot1.png		screenshot1.png
tca.mod		tca.mod
tonic.mod		tonic.mod

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<html><pre>
This is the readme for the model associated with the paper:

Yu J, Proddutur A, Elgammal FS, Ito T, Santhakumar V (2013) Status
epilepticus enhances tonic GABA currents and depolarizes GABA reversal
potential in dentate fast-spiking basket cells. J Neurophysiol
109:1746-63

These NEURON files were uploaded to ModelDB by Dr A Proddutur.  NEURON
is freely available at <a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>

These hoc files can replicate figure 11. A3 and B3.  In order to
replicate spike rasters from figure 11. Tonic conductance in basket
cell template and TC value need to be changed according to methods
presented in paper.

Usage:

Compile the mod files (nrnivmodl in linux/unix, mknrndll mac/mswin).
Run the model by starting one of the hoc files, e.g. in linux

nrngui fixed\ rseed\ Control\ -74\ spill_\ tonic\ 10uS\ with\ mossy\ kill.hoc

For this one, click the "Custom initialization" and then the "Custom
run" buttons.  After about a half hour (on a 2013 MacBook Pro laptop)
the following figures were generated:

<img src="./screenshot1.png" alt="screenshot 1" width="550">

Changelog:

2022-05: Updated MOD files to contain valid C++ and be compatible with the
         upcoming versions 8.2 and 9.0 of NEURON.
2022-09: Update MOD files to avoid declaring variables and functions with the same name.
         See neuronsimulator/nrn#1992

</pre></html>