Model files in the NEURON simulation environment (v7.7) from the paper

 

"Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs"

 

by Paola Vitale, Fabio Librizzi, Andrea C. Vaiana, Elisa Capuana, Maurizio Pezzoli, Ying Shi, Armando Romani, Michele Migliore and Rosanna Migliore 

Frontiers in Cellular Neuroscience, 2023

DOI: 10.3389/fncel.2023.1281932

Usage:

• Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux).

• Start the simulation by (unix/linux) typing on the command line: nrngui Figure3D.hoc or (mac os x) drag and dropping the Figure3D.hoc file on the nrngui icon or (mswin) double clicking on the Figure3D.hoc file.

• After selecting the experimental trace (on ''exp'' panel) and the corresponding phenotype (on ''model'' panel), simulation will reproduce the traces in Figure 3D of the paper.

• To test more parameters the user should could also handling the ''values'' panel and perform his own simulation.

 

Example: clicking on protocol "0.52" and running the simulation the window should produce the following graph: