Hippocampus CA1 pyramidal model with Na channel exhibiting slow inactivation (Menon et al. 2009)
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<html><pre> This folder contains files for NEURON simulations showing the effect of prolonged inactivation of sodium channels. There are two executable simulations in this folder. Either auto-launch from ModelDB, or download and extract the archive, compile the mod files and start by using nrngui with the mosinit.hoc file. See <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.html">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.html</a> for more help if needed. 1. Activity-dependent backpropagation of a train of action potentials (bAPs). (runs using file ri06_runAPtrain.hoc) This simulation shows the response of the neuron to a sustained somatic current injection. Voltage traces are plotted at the soma, at an intermediate dendrite, and at a distal dendrite. The degree of attentuation of the train of bAPs increases with distance from the soma. After you click "Init & Run" you should see traces similar to those in Figure 4A in the paper: <img src="./screenshot1.png" alt="screenshot 1" width="550"> 2. Suppression of dendritic spike generation by local depolarization. (runs using file ri06_runsyn.hoc) This simulation shows that prolonged inactivation of sodium channels induced by local depolarization is sufficient to suppress the initiation of a local dendritic spike. Local depolarization here can be generated either by a prior dendritic spike (Event type = 0, in the simulation) or a bAP (Event type = 1, in the simulation). Increasing the time between local depolarization and the dendritic-spike generating stimulus (Delay between stimulation events = 1500) allows the dendritic spike to be generated. In addition, replacing all the prolonged-inactivating sodium with fast-inactivating-only sodium conductance (Fraction of distal slow Na = 0) also allows the dendritic spike to be generated in both scenarios. This box allows you to experiment with these: <img src="./screenshot2.png" alt="screenshot 2"> After you click "Init & Run" you should see traces, which with the default parameters looks like <img src="./screenshot3.png" alt="screenshot 3" width="550"> Below are descriptions of the remaining hoc files in this folder: ri06.nrn: coordinates for the reconstructed neuron, including an artificial axon ri06_memb.hoc: contains all the membrane conductance parameters ri06_graphAPtrain.hoc: contains graphs for the backpropagating action potential train simulation (ri06_runAPtrain.hoc) ri06_graphsyn.hoc: contains graphs for the dendritic spike suppression simulation (ri06_runsyn.hoc)
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Hippocampus CA1 pyramidal model with Na channel exhibiting slow inactivation (Menon et al. 2009)
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