GitHub - ModelDBRepository/226812: 5-neuron-model of neocortex for producing realistic extracellular AP shapes (Van Dijck et al. 2012)

Branches Tags

Name		Name	Last commit message	Last commit date
Latest commit History 3 Commits
Electrodes		Electrodes
Fibres		Fibres
Granule_cell		Granule_cell
L5P37C-notuft		L5P37C-notuft
L5P37C-onlybasal		L5P37C-onlybasal
L5P37C		L5P37C
Network_5neuron_IMTEK		Network_5neuron_IMTEK
Output		Output
README.html		README.html
screenshot2.png		screenshot2.png
screenshot3.png		screenshot3.png
screenshot4.png		screenshot4.png
screenshot_a.png		screenshot_a.png

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This package contains the Genesis code for the simulations used in

Van Dijck G, Seidl K, Paul O, Ruther P, Van Hulle MM,  Maex R (2012) 
Enhancing the yield of high-density electrode arrays through automated 
electrode selection. Intl. J. Neural Systems 22, 1-19. 
doi: <a href="http://dx.doi.org/10.1142/S0129065712003055">10.1142/S0129065712003055</a>

These simulations were conducted with the genesis 2.3 release, on
MacPro running OSX.

For information and problems, please email Reinoud Maex at one of the
following addresses: reinoud.maex@ua.ac.be, r.maex1@herts.ac.uk,
reinoud.maex@ens.fr.

The program can be run in two ways:
- either running the whole network of 5 neurons: go to
dir Network_5neuron_IMTEK and type genesis Network.g
Once the simulation has started you can type

reset
step 14000

on the Genesis prompt. Color coded simulated neuronal activity is
displayed while time progresses (stills from these "movies" are used
in figures 4, 12, 14 in the paper)

<img src="./screenshot_a.png" width="550">

Neuronal activity is also depicted in voltage trace graphs:
<img src="./screenshot2.png" width="550">
<img src="./screenshot3.png" width="550">
<img src="./screenshot4.png" width="550">

- or running a single neuron: go to the respective dir
(L5P37C, L5P37C-notuft, L5P37C-onlybasal) and type
genesis L5P37C.g (L5P37C_notuft.g, L5P37C_onlybasal.g).

The dirs of each of the respective neurons are self-contained.
For running the network the code has been made more modular:
- Electrodes contains all code relevant to the electrodes.
- Output contains all code for graphical or ascii-file output.
- Fibres contains all code concerning the wiring.
Finally, Granule_cell is only a subsidiary dir containing the 
code for the channels used by the inhibitory neurons.

Usually you will run the program in one of two modes: either
as a test using online graphical output (xcell, xgraph, etc)
or for the real simulation saving all output (membrane potentials,
electrode potentials, etc) to ascii files.
Selecting the mode can easily be done by (un-)commenting out
the respective genesis commands.

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