GitHub - ModelDBRepository/240954: MDD: the role of glutamate dysfunction on Cingulo-Frontal NN dynamics (Ramirez-Mahaluf et al 2017)

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Name		Name	Last commit message	Last commit date
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MDD_spiking_model.py		MDD_spiking_model.py
MDD_spiking_model_severe.py		MDD_spiking_model_severe.py
readme.html		readme.html
screenshot.png		screenshot.png
spikes_E_dlPFC.dat		spikes_E_dlPFC.dat
spikes_E_vACC.dat		spikes_E_vACC.dat
spikes_I_dlPFC.dat		spikes_I_dlPFC.dat
spikes_I_vACC.dat		spikes_I_vACC.dat

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  <p/>A Brian (python) model for the paper:
  <p/>Ramirez-Mahaluf JP, Roxin A, Mayberg HS, Compte A (2017) A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics. <a href="http://dx.doi.org/10.1093/cercor/bhv249">Cereb Cortex</a> 27:660-679[<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26514163&dopt=Abstract">PubMed</a>]
  <p/>is available at the journal web site in the paper's supplementary material:
  <p/><a href="http://cercor.oxfordjournals.org/lookup/suppl/doi:10.1093/cercor/bhv249/-/DC1">http://cercor.oxfordjournals.org/lookup/suppl/doi:10.1093/cercor/bhv249/-/DC1</a>
  <p/>When run with a command like (after brian is installed):
  <p/>python MDD_spiking_model.py
  <p/>(after about 50 minutes on a 2013 MacBook Pro) a graph of the healthy switch in figure 2 in the paper is displayed:
  <p/><img src="./screenshot.png">
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