GitHub - ModelDBRepository/243842: Action potential of mouse urinary bladder smooth muscle (Mahapatra et al 2018)

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BKCAm.mod		BKCAm.mod
CAD.mod		CAD.mod
CaL.mod		CaL.mod
CaT.mod		CaT.mod
Exp2Syn.mod		Exp2Syn.mod
IH.mod		IH.mod
IKCA.mod		IKCA.mod
KATP.mod		KATP.mod
KCNQ.mod		KCNQ.mod
KV2.mod		KV2.mod
SKCA.mod		SKCA.mod
detrusor.hoc		detrusor.hoc
mosinit.hoc		mosinit.hoc
readme.html		readme.html
screenshot.png		screenshot.png
synapse.ses		synapse.ses

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<html>
This is the readme for the model associated with the paper:<p/>
Mahapatra C, Brain KL, Manchanda R (2018) A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle PLOS One<p/>
This model was contributed by C Mahapatra and requires NEURON which is freely a available from <a href="http://neuron.yale.edu/">http://neuron.yale.edu</a><p/>
<p/>
Fig 10A of the paper. Following a synaptic input, our model, in its
default setting, is able to generate spike type action potential with
an after depolarization riding on the repolarization phase. The
conductance, rising phase and falling phase time constants for the
synaptic conductance (see Exp2Syn) are set to 0.0095 μS, 15 ms, and 25
ms respectively.<p/>
How to run:<br/>
-----------<br/>
Compile the mod files (mknrndll on mswin or graphical mac os x, nrnivmodl on linux/unix) and then start detrusor.hoc (nrngui). If you need extra help please consult <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>
<p/>
Click the "Init & Run" button.  You should see a graph (similar to figure 10A in the paper):<p/>
<img src="./screenshot.png" alt=<"screenshot">
<p/>
By changing the conductance, rising phase, and falling
phase time constants values, this model can generate different types
of spikes which are shown in Fig 11C.
</html>