GitHub - ModelDBRepository/245805: Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo (Smith et al 2013)

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The NEURON and Brian code for the paper:<p/>
Smith SL, Smith IT, Branco T, Hausser M (2013) Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature 503:115-20
doi: <a href="http://dx.doi.org/10.1038/nature12600">http://dx.doi.org/10.1038/nature12600</a>
<p/>
is available at the link:<p/>
<a href="https://github.com/OpenSourceBrain/SmithEtAl2013-L23DendriticSpikes">https://github.com/OpenSourceBrain/SmithEtAl2013-L23DendriticSpikes</a><p/>
<hr/>
Example Use:<p/>
After downloading the model with a command like:<p/>
git clone https://github.com/OpenSourceBrain/SmithEtAl2013-L23DendriticSpikes
<p/>
You can cd to the NEURON/mod.files folder and compile the mod files with
a command like (linux):<p/>
nrnivmodl<p/>
(If you need more help for a different platform please consult this page:)<p/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a><p/>
Then in the libcell.py file change the line:<p/>
#load_mechanisms('/directory_where_mod_files_have_been_compiled')
<br/>to<br/>
load_mechanisms('./mod.files')
<p/>And then run simulations with the command:<p/>
python main.py
<p/>
Finally the command<p/>
python -i analyse.py<p/>
<p/>
Will produce images:<p/>
<img src="./screenshot.png" alt="screenshot" width="550"><p/>
similar to the soma and dendritic voltage traces seen
in the papers supplementary movies:<p/>
<a href="https://www.nature.com/articles/nature12600#s2">https://www.nature.com/articles/nature12600#s2</a>
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