LGMD impedance (Dewell & Gabbiani 2019)
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<p>The attached files reproduce simulations conducted for<p/>
"Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony" by Dewell and Gabbiani (2019) J Neurophysiol<br/>
<a href="http://dx.doi.org/10.1152/jn.00048.2019">http://dx.doi.org/10.1152/jn.00048.2019</a>
<p/>
It includes a detailed model of the lobula giant movement detector neuron (LGMD) which is a well studied neuron within the optic lobe of grasshoppers, and morphology files for 5 other neuron types. Attached are a number of files which setup the channel and membrane properties of the LGMD model and provide several example simulations.
</p>
If you need extra help running the NEURON model than provided below please consult this page:<p/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a><p/>
Note that the mod files are in a folder called mods (see linux command below).
<p>Auto-launch or Compile special:<br/>
The LGMD model uses several custom .mod files for channels and currents. The auto-launch link will use these mod files to compile a special executable version of NEURON with the additional membrane mechanisms. Alternatively, the mknrndll application or nrnivmodl binary can be used to compile the special version containg all custom channels.
</p>
<pre>
cd lgmd_impedance # change path to location on your computer
nrnivmodl ./mods # compile special executable
x86_64/special ./mosinit.hoc - # execute Neuron and initialize
</pre>
<p>For simulations resulting in figure 8:<br/>
load_file("LGMD/LGMDsynchro.hoc") # run the simulations
<p/>which produces in a few minutes:<p/>
<img src="./screenshot.png" width="600" alt="screenshot">
</p>
<p>For simulations resulting in figure 6 (takes about an hour):<br/>
load_file("passive_morphologies.hoc") # run the morphology simulations
</p>
<p>For simulations resulting in figure 7:(takes about 5 minutes)<br/>
load_file("cable.hoc") # run the simulations
</p>
<p>For simulations resulting in figure S3 (takes about 18 minutes):
load_file("RallMod.hoc") # run the Rall model
</p>
<p>20190808 dropbox update from Richard Dewell and additional touchups to
make fig 8 button work (from mosinit.hoc)</p>
<p/>20190812 more updates from Richard Dewell to annotate and provide closer
facsimile of figure 8.
<p/>20190814a non programming edits to provide length of times for simulation runs and corrected typo in program name in readme.
<p/>20190814b Richard Dewell corrected statement:
passive_morphologies.hoc doesn't have to be run before cable.hoc
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