GitHub - ModelDBRepository/258946: Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)

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Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)

modeldb.science/258946

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
shared		shared
Fig6_IO_burst_PSP_GABA_rectification.hoc		Fig6_IO_burst_PSP_GABA_rectification.hoc
Fig7_IO_burst_PSP_GABA_kinetics.hoc		Fig7_IO_burst_PSP_GABA_kinetics.hoc
Print-to-File.hoc		Print-to-File.hoc
exc.mod		exc.mod
inh.mod		inh.mod
initializationAndRun.hoc		initializationAndRun.hoc
make_dend_compartment.hoc		make_dend_compartment.hoc
nmdaSyn.mod		nmdaSyn.mod
readme.html		readme.html
screenshot.png		screenshot.png
start_simul.hoc		start_simul.hoc

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This is the readme for models that reproduce figure 7 in the paper:<p/>
Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2018) Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear a5-GABAA receptors. Nat Commun 9:3576<br/>
<a href="http://dx.doi.org/10.1038/s41467-018-06004-8">http://dx.doi.org/10.1038/s41467-018-06004-8</a><p/>
This NEURON code was contributed by JM Schulz.<p/>
The files contain the NEURON code for Fig.6 and Fig.7. The model is a single dendritic compartment with one glutamatergic and GABAergic synapse. Physiological properties of GABA synapses were modeled as determined by optogenetic activation of inputs during voltage-clamp recordings in Schulz et al. 2018. The simulation can be run by starting start_simul.hoc after running mknrndll. The files that model the individual figures have to be uncommented in start_simul.hoc beforehand.<p/>

If you need more help in running the model on your platform please consult:<br/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a><p/>

Running the start_simul.hoc (with nrngui) in its default state reproduces panels from figure 7:<p/>
<img src="./screenshot.png" alt="screenshot">
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