GitHub - ModelDBRepository/260178: Dendritic action potentials and computation in human layer 2/3 cortical neurons (Gidon et al 2020)

Branches Tags

Name		Name	Last commit message	Last commit date
Latest commit History 2 Commits
FigS12		FigS12
_classlib		_classlib
_mod		_mod
README.html		README.html
panelscreenshot.png		panelscreenshot.png
screenshot.png		screenshot.png

Repository files navigation

<html>
  <p>This is the readme for the author's model associated with Supplementary 12 in the paper:<p/>
 Gidon A, Zolnik TA, Fidzinski P, Bolduan F, Papoutsi A, Poirazi P, Holtkamp M, Vida I, Larkum ME (2020) Dendritic action potentials and computation in human layer 2/3 cortical neurons Science 367:83-87
  <br/>
  <a href="http://dx.doi.org/10.1126/science.aax6239">http://dx.doi.org/10.1126/science.aax6239</a><p/>
  </p>
  The author's models associated with supplementary figure 3 and S9 is available here:
  <a href="http://modeldb.yale.edu/254217">http://modeldb.yale.edu/254217</a>
<p>Model usage:<br/>

  This code was written in and requires NEURON (tested in version 7.4,
  7.7) which is freely available
  from <a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>

  This model was run under the unix/linux and windows 10 operating system.
</p>
<p>Proceed as follows:<br/>
- Download and expand this archive and compile the mod files located in the "_mod" folder with nrnivmodl ("nrnivmodl _mod" or "nrnivmodl ../_mod" if running in  the FigS12 subfolder)).
</p>
<ul>
  <li>run the demo for unix/linux:
x84/64/special mosinit.hoc
</li></ul>
<p>or for windows double click mosinit.hoc
</p>
If you need more help running NEURON on your platform please consult:<p/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide</a>
<p/>
Once the code is running you can "tickle" the taur_cad time constant in the window:<p/>
<img src="./panelscreenshot.png" alt="panel screenshot">
  <p/>
For example, by clicking the check box twice, or by entering a return after the 60, a graph similar to Fig S12 B2 is generated:
  <p/>
  <img src="./screenshot.png" alt="screenshot">
</html>