GitHub - ModelDBRepository/260192: Hyperexcitable neurons encoding in the superficial retrosplenial cortex (Brennan et al 2020)

Branches Tags

Name		Name	Last commit message	Last commit date
Latest commit History 4 Commits
AHP.mod		AHP.mod
LR_neuron_tuned.hoc		LR_neuron_tuned.hoc
README.html		README.html
RS_neuron_tuned.hoc		RS_neuron_tuned.hoc
kd.mod		kd.mod
kdrs1.mod		kdrs1.mod
kdrs1_LR.mod		kdrs1_LR.mod
nas_rs.mod		nas_rs.mod
screenshot1.png		screenshot1.png
screenshot2.png		screenshot2.png
test_model_LR.hoc		test_model_LR.hoc
test_model_RS.hoc		test_model_RS.hoc

Repository files navigation

<html>
<p>This is the Readme for the model associated with the paper:
</p><p>Ellen K.W. Brennan, Shyam Kumar Sudhakar, Izabela Jedrasiak-Cape, Tibin T. John &amp; Omar J. Ahmed, Hyperexcitable neurons enable precise and persistent information encoding in the superficial retrosplenial cortex, Cell Reports
</p>
<p>File descriptions
</p><hr/>
<p>LR_neuron_tuned.hoc - Neuron template of Low Rheobase (LR) neuron described in the paper<br/>
RS_neuron_tuned.hoc - Neuron template of Regular spiking (RS) neuron described in the paper<br/>
test_model_RS.hoc - Test file to run the RS neuron model<br/>
test_model_LR.hoc - Test file to run the LR neuron model<br/>
</p>
<p>How to run the model
</p><hr/>
<p>Download all files to your computer and cd to the corresponding folder
  On the terminal, type "mknrndll (or nrnivmodl)" to complile the .mod files <br/>
  If you need more help running NEURON on your platform please consult:<br/>
  <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide</a><br/>
</p><p>Type "nrngui test_model_RS.hoc" or " nrngui test_model_LR.hoc" to run 
the model
</p>
<p>test_model_RS.hoc - creates figure 6B of the paper (low current)<br/>
  <img src="./screenshot1.png" alt="screenshot 1"><p/>
    test_model_LR.hoc - creates figure 6F of the paper (low current)<br/>
  <img src="./screenshot2.png" alt="screenshot 2"><p/>
</p><p>For generating the FI curves (Figure 6D and 6H), please use current 
clamp (already inserted in the template files) with a delay of 
500 ms and duration of 1000 ms.
</p><p>For accurate results, use a dt of 0.025 ms.
</p><p>In case of any questions, please send an email to <a href="mailto:shyamk@umich.edu">shyamk@umich.edu</a>
</html>