GitHub - ModelDBRepository/266848: Age-dependent excitability of CA1 pyramidal neurons in APPPS1 Alzheimer's model (Vitale et al 2021)

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Age-dependent excitability of CA1 pyramidal neurons in APPPS1 Alzheimer's model (Vitale et al 2021)
modeldb.science/266848
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<p class=MsoNormal>Model files in the NEURON simulation environment (v8.0) from
the paper</p>

<p class=MsoNormal>&nbsp;</p>

<p class=MsoNormal>&quot;Analysis of age-dependent alterations in excitability
properties of CA1 pyramidal neurons in an APPPS1 model of Alzheimer's
disease&quot;</p>

<p class=MsoNormal><span lang=IT style='mso-ansi-language:IT'>by Paola Vitale,
Ana Rita <span class=SpellE>Salgueiro</span>-Pereira, Carmen Alina <span
class=SpellE>Lupascu</span>, Rosanna Migliore, Michele Migliore and Helene
Marie<o:p></o:p></span></p>

<p class=MsoNormal><span lang=IT style='mso-ansi-language:IT'>&nbsp;<o:p></o:p></span></p>

<p class=MsoNormal>Frontiers in Aging Neuroscience 2021</p>

<p class=MsoNormal>&nbsp;</p>

<p class=MsoNormal>Usage:</p>

<p class=MsoListParagraph style='text-indent:-.25in'><span style='font-family:
Symbol'>·</span><span style='font-size:7.0pt;line-height:105%;font-family:"Times New Roman",serif'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span>Compile the mod files with <span class=SpellE>mknrndll</span> (<span
class=SpellE>mswin</span> or graphical mac) or <span class=SpellE>nrnivmodl</span>
(<span class=SpellE>unix</span>/<span class=SpellE>linux</span>)). </p>

<p class=MsoListParagraph style='text-indent:-.25in'><span style='font-family:
Symbol'>·</span><span style='font-size:7.0pt;line-height:105%;font-family:"Times New Roman",serif'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span>Start the simulation by (<span class=SpellE>unix</span>/<span
class=SpellE>linux</span>) typing on the command line: <span class=SpellE>nrngui</span>
Figure3D.hoc or (mac <span class=SpellE>os</span> x) drag and dropping the
Figure3D.hoc file on the <span class=SpellE>nrngui</span> icon or (<span
class=SpellE>mswin</span>) double clicking on the Figure3D.hoc file.</p>

<p class=MsoListParagraph style='text-indent:-.25in'><span style='font-family:
Symbol'>·</span><span style='font-size:7.0pt;line-height:105%;font-family:"Times New Roman",serif'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span>After selecting the experimental trace (on ''exp'' panel) and the
corresponding phenotype (on ''model'' panel), simulation will reproduce the
traces in Figure 3D of the paper.</p>

<p class=MsoListParagraph style='text-indent:-.25in'><span style='font-family:
Symbol'>·</span><span style='font-size:7.0pt;line-height:105%;font-family:"Times New Roman",serif'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span><span class=GramE>To</span> test more parameters the user should could
also handling the ''values'' panel and perform his own simulation.</p>

<p class=MsoNormal>&nbsp;</p>

<p class=MsoNormal>Example: clicking on &quot;exp -0.15 WT-10m&quot; and
&quot;WT-10m&quot; and running the simulation the window should produce the
following graph:</p>

<p class=MsoNormal>&nbsp;</p>

<p class=MsoNormal align=center style='text-align:center'><span
style='mso-no-proof:yes'><!--[if gte vml 1]><v:shapetype id="_x0000_t75"
 coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe"
 filled="f" stroked="f">
 <v:stroke joinstyle="miter"/>
 <v:formulas>
  <v:f eqn="if lineDrawn pixelLineWidth 0"/>
  <v:f eqn="sum @0 1 0"/>
  <v:f eqn="sum 0 0 @1"/>
  <v:f eqn="prod @2 1 2"/>
  <v:f eqn="prod @3 21600 pixelWidth"/>
  <v:f eqn="prod @3 21600 pixelHeight"/>
  <v:f eqn="sum @0 0 1"/>
  <v:f eqn="prod @6 1 2"/>
  <v:f eqn="prod @7 21600 pixelWidth"/>
  <v:f eqn="sum @8 21600 0"/>
  <v:f eqn="prod @7 21600 pixelHeight"/>
  <v:f eqn="sum @10 21600 0"/>
 </v:formulas>
 <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/>
 <o:lock v:ext="edit" aspectratio="t"/>
</v:shapetype><v:shape id="Immagine_x0020_2" o:spid="_x0000_i1025" type="#_x0000_t75"
 style='width:481.5pt;height:259.5pt;visibility:visible;mso-wrap-style:square'>
 <v:imagedata src="readme_file/image001.jpg" o:title=""/>
</v:shape><![endif]--><![if !vml]><img width=1000 height=539
src="readme_file/image001-rm.JPG" v:shapes="Immagine_x0020_2"><![endif]></span></p>

<p class=MsoNormal>&nbsp;</p>

<p class=MsoNormal>Questions on how to use this model should be directed to <a
href="mailto:paola.vitale@ibf.cnr.it">paola.vitale@ibf.cnr.it</a> or to michele.migliore@cnr.it</p>

<p class=MsoNormal>All electrophysiological traces and morphologies used for
the models are available at the Human Brain Project collab
https://humanbrainproject.github.io/hbp-bsp-live-papers/2021/vitale_et_al_2021/vitale_et_al_2021.html</p>

<p class=MsoNormal>Access to this resource requires free user registration at
https://www.humanbrainproject.eu/en/hbp-platforms/getting-access/</p>

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