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Long-Term Inactivation of Na+ Channels as a Mech of Adaptation in CA1 Pyr Cells (Upchurch et al 2022)
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<html> This is the NEURON code associated with the paper:<p/> Upchurch CM, Combe CL, C Knowlton, V Rousseau, Gasparini S, Canavier CC, (2021) Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Cells. <br/> <p/> This model entry was contributed by C Canavier. The freely available NEURON simulation enivronment (from <a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>) is required for this model.<p/> To use:<br/> -------<br/> Autolaunch from modeldb if the browser is capable or compile the mod files and start with mosinit.hoc (easiest) (If you need more help to run the model, please refer to:<br/> <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>)<p/> On linux for example typing<br/> nrngui init.hoc <br/> Will generate 2 panels asking what simulation wou want to run, the first panel will produce simulations from figure 4 and figure 6 of the paper, the second panel will produce simulations from the extended figure 6:<p/> <img src="./initpanels.png" width="550"> <p/> running one of these simulations will produce a shape plot, a plot of the applied current, a voltage plot, and if applicable a states plot<p/> <img src="./screenshot.png" width="550"> <p/> Additional running notes:<br/> -------------------------<br/> <p/> Interspike intervals and frequencies were analyzed offline, as well as Figure 5. sum_currents_of_interest.hoc sums current through Nav1.6 through all parts of the neuron and records it in a text file. sum_capacitive_current.hoc sums capacitive current throughout the neuron and records it in a text file. square_pulse.hoc is a square pulse used to evaluate the input resistance. <p/> </html>
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Long-Term Inactivation of Na+ Channels as a Mech of Adaptation in CA1 Pyr Cells (Upchurch et al 2022)