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Computational model of cerebellar tDCS (Zhang et al., 2021)
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<html> <body> <p> # README for Crbl_tDCS_Zhang2021 Simulation code for Zhang, X., Hancock, R., and Santaniello, S. (2021) Transcranial Direct Current Stimulation of Cerebellum Alters Spiking Precision in Cerebellar Cortex: A Modeling Study of Cellular Responses. PLoS Comp Biol. DOI: 10.1371/journal.pcbi.1009609. </p> <p> Dependencies: <ul> <li> NEURON v.7.7 or later (may run on some older versions)</li> <li> MATLAB r2017a or later (may run on some older versions)</li> </ul> </p> <p> The codes were executed on Windows 10. Not tested on other operating systems (Unix/macOS etc). </p> <p> To run simulations for granule cells: <ol> <li> Compile NEURON mechanisms in the (./Granule/mod_files/) folder using the mknrndll executable; copy the generated nrnmech.dll file to the (./Granule/) folder.</li> <li>In MATLAB, run the script "tDCSsearch_GrC.m", which sets parameters for the tDCS-induced electric field intensity and filenames. It then calls the NEURON script "mosinit_tDCS_synapse_189-1-33dw.hoc" which simulates the granule cell activity under synaptic inputs under the given tDCS settings.</li> </ol> </p> <p> To run simulations for deep cerebellar nuclear cells: <ol> <li>Compile NEURON mechanisms in the (./DCN/mod_files/) folder using the mknrndll executable; copy the generated nrnmech.dll file to the (./DCN/) folder.</li> <li>In MATLAB, run the script "tDCSsearch_DCN.m", which sets parameters and calls the NEURON script "mosinit_tDCS_synapse_189-1-33dw.hoc". The latter simulates the DCN activity during rebound spiking under the given tDCS settings.</li> </ol> </p> <p> To run simulations for Purkinje cells: <ol> <li>Compile NEURON mechanisms in the (./Purkinje/mod_files/) folder using the mknrndll executable; copy the generated nrnmech.dll file to the (./Purkinje/) folder.</li> <li>In MATLAB, run the script "tDCSsearch_dend_train_delayedonset.m", which sets parameters and calls the NEURON script "mosinit_tDCS_synapse_189-1-33dw.hoc". The latter simulates the Purkinje cell activity under mossy fiber inputs under the given tDCS settings.</li> <li>Run the script "tDCSsearch_1cs.m", which sets parameters and calls the NEURON script "mosinit_tDCS_1cs.hoc". The latter simulates the Purkinje cell activity under climbing fiber inputs under the given tDCS settings.</li> <li>Run the script "tDCSsearch_caspike.m", which sets parameters and calls the NEURON script "mosinit_tDCS_caspike.hoc". The latter simulates the Purkinje cell calcium bursting activity under the given tDCS settings.</li> <li>Run the script "Vshift_search_calcium.m", which sets parameters and calls the NEURON script "mosinit_calcium_soma_vshift.hoc" or "mosinit_calcium_dend_vshift.hoc". The latter two simulate the Purkinje cell calcium bursting activity under voltage shifts applied to soma or dendritic compartments.</li> </ol> </p> <p> Scripts used to generate all the figures in the article, including estimated EF values and simulated values for all voxels in head models accrue to over 4 GB and are available at the link: <a href="https://drive.google.com/drive/folders/1udxxdToV9zuXK7h27znhCWIkQHau0D2w?usp=sharing">https://drive.google.com/drive/folders/1udxxdToV9zuXK7h27znhCWIkQHau0D2w?usp=sharing</a> </p> </body> </html>
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Computational model of cerebellar tDCS (Zhang et al., 2021)