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Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Potential Implications for Place Cell Firing (Combe et al., 2023)
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<html> This is the NEURON code associated with the paper:<p/> Combe CL, Upchurch CM, Canavier CC, Gasparini S, (2022) Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Implications for Place Field Firing <br/> <p/> This model entry was contributed by C Canavier. The freely available NEURON simulation enivronment (from <a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>) is required for this model.<p/> To use:<br/> -------<br/> Autolaunch from modeldb if the browser is capable or compile the mod files and start with mosinit.hoc (easiest) (If you need more help to run the model, please refer to:<br/> <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>)<p/> On linux for example typing<br/> nrngui init.hoc <br/> Will generate a panels asking what simulation wou want to run.<p/> <p/> running one of these simulations will produce a shape plot, a voltage plot, and plots of the calcium concentration in the outermost shell, nanodomain, TRPM4 activation and resulting TRPM4 current in the soma <p/> <p/> <p/> The simulation that reads the original carbachol simulation's calcium and plays it into the model without a voltage dependence cannot be run untill the calcium has been saved. To do this create a folder "nanodomain_data" and run save_can_from_fig9.hoc <p/> <p/> Additional running notes:<br/> -------------------------<br/> <p/> Interspike intervals and frequencies were analyzed offline. <p/> </html>
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Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Potential Implications for Place Cell Firing (Combe et al., 2023)