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Juke34 committed Apr 15, 2021
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Expand Up @@ -34,12 +34,12 @@ It's often hard to understand and differentiate all GFF/GTF formats/flavors. Man
* [Evolution of the 3rd and 9th column](#evolution-of-the-3rd-and-9th-column)
* [Difference between GENCODE and Ensembl GTF](#difference-between-gencode-and-ensembl-gtf)

## Forewords
### Forewords
⇨ When I use the term gff it includes all gff formats/flavors. (The first version of the format was not called gff1 but gff. But to make it easier I will always specify the version of the format saying gff1 when I talk about the first version of it).
⇨ I the same way, when I use the term gtf it includes all gtf formats/flavors.
⇨ I have created the term **gxf** that means all the gff and gtf formats/flavors.

## Introduction
### Introduction

**GFF (Gene-Finding Format)** is a general-purpose genome annotation format. It was conceived during a 1997 meeting on computational genefinding at the Isaac Newton Institute, Cambridge, UK and developed in collaboration between the Sanger Centre, the University of California at Santa Cruz and other participants (_Holmes I: Studies in Probabilistic Sequence Alignment and Evolution. PhD thesis University of Cambridge 1998._). The key players have been **Richard Durbin** and **David Haussler**.

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SEQ3 BLASTX similarity 235 260 . + 2 Target "HBA_HUMAN" ; E_value 0.0005
SEQ3 BLASTX similarity 360 396 . + 0 Target "HBA_HUMAN" ; E_value 0.001

## GFF3
### GFF3
(2004)

GFF3 addresses several shortcomings in its predecessor GFF2. Actually it addresses the most common extensions to GFF, while preserving back-ward compatibility with previous formats. It has been conceptualized by by **Lincoln Stein**. [The First specification draft](https://web.archive.org/web/20031207182031/http://song.sourceforge.net:80/gff3.shtml) I found is from 10 September 2003 (version 1.00rc1). [The first offical specification](http://rice.bio.indiana.edu:7082/annot/gff3.html) is the version 1 published the 30 September 2004.
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