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usage of the cell abundance scores #5

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cjhong opened this issue Mar 14, 2021 · 1 comment

cjhong commented Mar 14, 2021

I would like to use the estimated cell abundance from res$beta.

Can I use these cell abundance scores to compare across multiple samples?

Can I use these cell abundance scores between cell-types in a patient sample?

Thank you!

Collaborator

patrickjdanaher commented Mar 24, 2021

Can I use these cell abundance scores to compare across multiple samples?

yes!
Can I use these cell abundance scores between cell-types in a patient sample?
yes, but with less certainty. This comparison depends on the columns of the cell profile matrix correctly representing the total RNA content in each cell type. We have made every effort to ensure this with the safeTME, but our solution is undoubtedly imperfect.

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