Population plots: Demography

[Yuri05]

Inputs

• Output folder of the Simulate population task (with calculated simulation results)
• Output Folder for results (all results will be generated here)
• OPTIONAL Number of Cores
• Type. One of:
  • Pediatric: one population may be marked as (adult) reference
  • Parallel comparison: no population is marked as special.
  • Ratio comparison:
    • special case for analysis of one property of a population (e.g. GFR)
    • one population (e.g. "healthy") is marked as reference
    • for all other (e.g. "diseased") populations: ratios of all PK Parameters to the corresponding healthy one is calculated and plotted as Box-Whisker plot
• 1 or more populations
• List of datasets
• Settings (s. also getDefaultDemographySettings #12)
  • Reference population (only filled for pediatric)
  • Reference data set must be plotted as well
  • List of parameters for x axis incl display units
    • For Type "pediatric": Default: Age [year(s)]
    • For other Types: Default:empty (Histogram plot will be created)
  • List of parameters for y axis incl display units
    • For Type "pediatric": any of
      • "Characteristics of Individual"-parameters (Age, Weight, Height, BMI, BSA,Gender, ...)
      • ontogenies of the model (=OntogenyFactorLiver/GI per enzyme + OntogenieFactor Albumin/...)
    • For other Types: any of "Characteristics of Individual"-parameters

Outputs

In the output folder: all plots/tables as specified in the settings

• if x parameter list is empty: Histogramms for all parameters in y parameter List
  • If there are more than one population:

    • for Type=pediatric: all Populations in one plot

    • for Type=Parallel comparison or Ratio comparison: one plot per population

  • If there is observed data in the assigned data set for the given parameter: plot histogrqam of observed data in the same plot as well.

• If x parameter list is not empty: range plots for all parameters of y list vs all parameters of x list (N x M plots)
  • Range: 5-95% (prio 2: can be defined by user) + Median
  • In one plot: 1 population plus reference population
    • For the reference population: mean/(geo)SD range us plotted (always const)
• Tables: currently NONE